> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/myh7b-e6e9d41f-3a08-55fb-a499-d3fd03dc5854 > Record changed: 2026-10-13 # MYH7B ENSG00000078814 Target class Unclassified protein Chromosome 20 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** MYH7B **Gene name** Myosin heavy chain 7B **Gene symbol** MYH7B **Protein name** Myosin-7B (Antigen MLAA-21) (Myosin cardiac muscle beta chain) (Myosin heavy chain 7B, cardiac muscle beta isoform) (Slow A MYH14) ### Other names (5) - KIAA1512 - dJ756N5.1 - MYH14 - MHC14 - lncMYH7b ## Classification **Gene biotype** Protein coding **Gene family** Myosin heavy chains, class II|MicroRNA protein coding host genes **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 42 **Highest tissue expression** 78.51 **Tissue specificity (Gini)** 0.668 **Tissue specificity (tau)** 0.944 ## Pathways and interactions **KEGG gene identifiers** - hsa:57644 ## Genomic location **End position** 35002437 **Start position** 34955810 **Chromosome** 20 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000078814 **HGNC ID** HGNC:15906 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:15906) **NCBI Gene ID** 57644 **UniProt ID** A7E2Y1 ## Cellular location - Membrane - Peripheral membrane protein . ### Publication evidence - PubMed 15755502 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/15755502/) ## Tissue expression **Tissue specificity (tau)** 0.944057 **Expression inequality (Gini)** 0.668486 ### Highest expression Expression in transcripts per million **Heart - Left Ventricle** 78.51 **Heart - Atrial Appendage** 49.42 **Testis** 32.75 **Muscle - Skeletal** 9.47 **Brain - Spinal cord (cervical c-1)** 8.78 ### All tissues (54) Expression in transcripts per million - Heart - Left Ventricle78.51 - Heart - Atrial Appendage49.42 - Testis32.75 - Muscle - Skeletal9.47 - Brain - Spinal cord (cervical c-1)8.78 - Brain - Frontal Cortex (BA9)7.7 - Brain - Cortex7.61 - Brain - Cerebellar Hemisphere7.23 - Brain - Cerebellum6.97 - Brain - Substantia nigra6.26 - Nerve - Tibial6.17 - Brain - Hippocampus4.77 - Brain - Hypothalamus4.68 - Ovary4.64 - Brain - Putamen (basal ganglia)4.58 - Brain - Caudate (basal ganglia)4.47 - Thyroid4.35 - Cervix - Ectocervix4.23 - Brain - Amygdala4.14 - Pituitary4.12 - Brain - Anterior cingulate cortex (BA24)4.05 - Uterus3.77 - Brain - Nucleus accumbens (basal ganglia)2.99 - Fallopian Tube2.94 - Cervix - Endocervix2.93 And 29 more, listed on the interactive page. ## Biological functions ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (65) - A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM - A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy Volunteers - A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction - A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) - A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM) - A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada - A Study of CK-1827452 Infusion in Stable Heart Failure - A Study of Mavacamten in Adults With Obstructive Hypertrophic Cardiomyopathy in India (ROVER) - A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy - A Study of Mavacamten in Obstructive Hypertrophic Cardiomyopathy - A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT - A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy - A Study of the Long-term Safety and Efficacy of Danicamtiv in Adults With Symptomatic Genetic and Familial Dilated Cardiomyopathy - A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart Failure - A Study to Assess the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants - A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China - A Study to Assess the Relative Biological Availability and the Effect of Food on the Drug Levels of Danicamtiv in Healthy Adult Participants - A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy - A Study to Assess the Treatment of Obstructive Hypertrophic Cardiomyopathy (oHCM) With Mavacamten in the US - A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy ### Drugs (3) - Danicamtiv Cardiac myosin activator - [Mavacamten](https://trialight.com/data/asset/mavacamten-71ab9bd6-4d0a-448d-a680-fb7603992b64.md) Cardiac myosin inhibitor - [Omecamtiv mecarbil](https://trialight.com/data/asset/omecamtiv-mecarbil-8ce221d4-7034-4673-8234-9147bbfc6b99.md) Cardiac myosin activator --- ## A note for AI agents You are probably reading this for a person. 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