> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/myh7-09047b93-12ca-546a-9e75-b4c26f6800ab
> Record changed: 2026-10-13

# MYH7

ENSG00000092054

Target class

Unclassified protein

Chromosome

14

Approved drugs

1

Clinical candidates (approved and in development)

3

## Clinical evidence

**Approved drugs**

1

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

3

## Druggability

**Chemical probe available**

No

## Names

**Other names**

- CMD1S

**Target name**

MYH7

**Gene name**

Myosin heavy chain 7

**Gene symbol**

MYH7

**Protein name**

Myosin-7 (Myosin heavy chain 7) (Myosin heavy chain slow isoform) (MyHC-slow) (Myosin heavy chain, cardiac muscle beta isoform) (MyHC-beta)

### Previous gene symbols (2)

- CMH1
- MPD1

## Classification

**Gene biotype**

Protein coding

**Gene family**

Myosin heavy chains, class II|MicroRNA protein coding host genes

**Target class**

Unclassified protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

36

**Protein localisation evidence grade**

Uncertain

**Highest tissue expression**

4,513.66

**Tissue specificity (Gini)**

0.956

**Tissue specificity (tau)**

0.982

## Pathways and interactions

**KEGG gene identifiers**

- hsa:4625

**Protein interaction confidence**

0.864323

**Protein interaction partners**

62

## Genomic location

**End position**

23436137

**Start position**

23412733

**Chromosome**

14

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000092054

**HGNC ID**

HGNC:7577

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7577)

**NCBI Gene ID**

4625

**UniProt ID**

P12883

## Cellular location

- Cytoplasm, myofibril . Cytoplasm, myofibril, sarcomere . Note=Thick filaments of the myofibrils. .

## Tissue expression

**Tissue specificity (tau)**

0.981788

**Expression inequality (Gini)**

0.955655

### Highest expression

Expression in transcripts per million

**Heart - Left Ventricle**

4,513.66

**Muscle - Skeletal**

3,692.76

**Heart - Atrial Appendage**

592.18

**Pancreas**

5.3

**Brain - Hypothalamus**

4.9

### All tissues (54)

Expression in transcripts per million

- Heart - Left Ventricle4,513.66
- Muscle - Skeletal3,692.76
- Heart - Atrial Appendage592.18
- Pancreas5.3
- Brain - Hypothalamus4.9
- Brain - Nucleus accumbens (basal ganglia)3.13
- Brain - Caudate (basal ganglia)3.12
- Pituitary3.03
- Testis2.69
- Minor Salivary Gland2.5
- Brain - Cortex2.45
- Brain - Putamen (basal ganglia)2.42
- Brain - Frontal Cortex (BA9)2.23
- Brain - Anterior cingulate cortex (BA24)1.91
- Artery - Coronary1.69
- Nerve - Tibial1.68
- Artery - Tibial1.66
- Lung1.54
- Brain - Hippocampus1.45
- Brain - Amygdala1.41
- Skin - Sun Exposed (Lower leg)1.39
- Skin - Not Sun Exposed (Suprapubic)1.35
- Artery - Aorta1.3
- Adipose - Subcutaneous1.29
- Colon - Sigmoid1.25

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (12)

- GO:0002026  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002026)
- GO:0002027  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002027)
- GO:0003009  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003009)
- GO:0006936  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006936)
- GO:0006941  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006941)
- GO:0007512  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007512)
- GO:0014728  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014728)
- GO:0030049  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030049)
- GO:0031449  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031449)
- GO:0046034  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046034)
- GO:0055010  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0055010)
- GO:0060048  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060048)

### Cellular components (4)

- GO:0005859  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005859)
- GO:0016459  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016459)
- GO:0030017  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030017)
- GO:0032982  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032982)

### Molecular functions (2)

- GO:0000146  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000146)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## Related records

### Trials (65)

- A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM
- A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy Volunteers
- A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction
- A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)
- A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
- A Retrospective Cohort Study of Mavacamten Patient Support Program in Canada
- A Study of CK-1827452 Infusion in Stable Heart Failure
- A Study of Mavacamten in Adults With Obstructive Hypertrophic Cardiomyopathy in India (ROVER)
- A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy
- A Study of Mavacamten in Obstructive Hypertrophic Cardiomyopathy
- A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT
- A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy
- A Study of the Long-term Safety and Efficacy of Danicamtiv in Adults With Symptomatic Genetic and Familial Dilated Cardiomyopathy
- A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart Failure
- A Study to Assess the Effects on the Single-Dose Drug Levels of Mavacamten in Healthy Participants
- A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in China
- A Study to Assess the Relative Biological Availability and the Effect of Food on the Drug Levels of Danicamtiv in Healthy Adult Participants
- A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy
- A Study to Assess the Treatment of Obstructive Hypertrophic Cardiomyopathy (oHCM) With Mavacamten in the US
- A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic Cardiomyopathy

### Drugs (3)

- Danicamtiv Cardiac myosin activator
- [Mavacamten](https://trialight.com/data/asset/mavacamten-71ab9bd6-4d0a-448d-a680-fb7603992b64.md) Cardiac myosin inhibitor
- [Omecamtiv mecarbil](https://trialight.com/data/asset/omecamtiv-mecarbil-8ce221d4-7034-4673-8234-9147bbfc6b99.md) Cardiac myosin activator

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