> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/muc5ac-40d03189-f4c7-571e-8749-d54dac38aff1 > Record changed: 2026-10-13 # MUC5AC ENSG00000215182 Target class Secreted protein Chromosome 11 Approved drugs 0 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Other names** - MUC5 **Target name** MUC5AC **Gene name** Mucin 5AC, oligomeric mucus/gel-forming **Gene symbol** MUC5AC **Protein name** Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) ## Classification **Gene biotype** Protein coding **Gene family** Mucins **Target class** Secreted protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Protein localisation evidence grade** Uncertain **Highest tissue expression** 132.81 **Tissue specificity (Gini)** 0.977 **Tissue specificity (tau)** 1 ## Pathways and interactions **KEGG gene identifiers** - hsa:4586 **Protein interaction confidence** 0.820167 **Protein interaction partners** 30 ### Reactome pathways (6) - R-HSA-5083625 - R-HSA-5083632 - R-HSA-5083636 - R-HSA-5621480 - R-HSA-913709 - R-HSA-977068 ## Genomic location **End position** 1201138 **Start position** 1157953 **Chromosome** 11 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000215182 **HGNC ID** HGNC:7515 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7515) **NCBI Gene ID** 4586 **UniProt ID** P98088 ## Cellular location - Secreted . ### Publication evidence (2) - PubMed 14718370 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/14718370/) - PubMed 31732694 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/31732694/) ## Tissue expression **Tissue specificity (tau)** 0.999805 **Expression inequality (Gini)** 0.977109 ### Highest expression Expression in transcripts per million **Stomach** 132.81 **Testis** 0.32 **Lung** 0.12 **Cervix - Endocervix** 0.1 **Minor Salivary Gland** 0.07 ### All tissues (54) Expression in transcripts per million - Stomach132.81 - Testis0.32 - Lung0.12 - Cervix - Endocervix0.1 - Minor Salivary Gland0.07 - Prostate0.06 - Cervix - Ectocervix0.05 - Fallopian Tube0.05 - Pituitary0.03 - Uterus0.03 - Colon - Transverse0.03 - Vagina0.03 - Bladder0.03 - Esophagus - Mucosa0.02 - Small Intestine - Terminal Ileum0.02 - Pancreas0.02 - Spleen0.02 - Cells - EBV-transformed lymphocytes0.02 - Ovary0.02 - Esophagus - Gastroesophageal Junction0.02 - Artery - Aorta0.02 - Brain - Cerebellum0.02 - Adrenal Gland0.02 - Liver0.01 - Esophagus - Muscularis0.01 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components (5) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005796 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005796) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0070701 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070701) ### Molecular functions - GO:0005201 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005201) ## Related records ### Trials (8) - A Study of Fractionated 90Y-hPAM4 Plus Gemcitabine in Pancreatic Cancer Patients Receiving at Least 2 Prior Therapies. - [A Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors.](https://trialight.com/data/trial/a-study-of-muc16-directed-antibody-drug-conjugate-hwk-016-in-548b132b-ea69-4673-b544-093f6e3556e5.md) - Multi-Targeted Recombinant Ad5 (CEA/MUC1/Brachyury) Based Immunotherapy Vaccine Regimen in People With Advanced Cancer - Phase 3 Trial of 90Y-Clivatuzumab Tetraxetan & Gemcitabine vs Placebo & Gemcitabine in Metastatic Pancreatic Cancer - QUILT-3.010: A Study of Gemcitabine and Nab-paclitaxel With or Without NPC-1C to Treat Patients With Pancreatic Cancer - QUILT-3.019: Phase 2 Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer - Safety and Efficacy Study of 90Y-hPAM4 at Different Doses - Safety and Efficacy Study of Different Doses of 90Y-hPAM4 Combined With Gemcitabine in Pancreatic Cancer ### Drugs (3) - [Clivatuzumab tetraxetan](https://trialight.com/data/asset/clivatuzumab-tetraxetan-7c497012-b7b3-4d22-91fc-5e7f1f28682a.md) Mucin-5AC binding agent - Ensituximab Mucin-5AC other - Yttrium Y 90 clivatuzumab tetraxetan Mucin-5AC binding agent --- ## A note for AI agents You are probably reading this for a person. 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