> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/mt-nd1-da56bfa6-9109-5230-9fab-1feb175e18e8 > Record changed: 2026-10-13 # MT-ND1 ENSG00000198888 Target class Enzyme Chromosome Mitochondrial Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** MT-ND1 **Gene name** Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 **Gene symbol** MT-ND1 **Previous gene symbols** - MTND1 **Protein name** NADH-ubiquinone oxidoreductase chain 1 (EC 7.1.1.2) (NADH dehydrogenase subunit 1) ### Other names (2) - ND1 - NAD1 ## Classification **Gene biotype** Protein coding **Gene family** NADH:ubiquinone oxidoreductase core subunits|Mitochondrially encoded protein coding genes **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 44,249.1 **Tissue specificity (Gini)** 0.296 **Tissue specificity (tau)** 0.512 ## Pathways and interactions **KEGG gene identifiers** - hsa:4535 **Protein interaction confidence** 0.934981 **Protein interaction partners** 108 ### Reactome pathways (4) - R-HSA-5419276 - R-HSA-611105 - R-HSA-6799198 - R-HSA-9837999 ## Genomic location **End position** 4262 **Start position** 3307 **Chromosome** Mitochondrial **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000198888 **HGNC ID** HGNC:7455 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7455) **NCBI Gene ID** 4535 **UniProt ID** P03886 ## Cellular location - Mitochondrion inner membrane - Multi-pass membrane protein . ## Tissue expression **Tissue specificity (tau)** 0.511921 **Expression inequality (Gini)** 0.295878 ### Highest expression Expression in transcripts per million **Brain - Cortex** 44,249.1 **Brain - Substantia nigra** 42,117.3 **Brain - Putamen (basal ganglia)** 40,902.9 **Brain - Amygdala** 39,954.5 **Brain - Hippocampus** 39,582.1 ### All tissues (54) Expression in transcripts per million - Brain - Cortex44,249.1 - Brain - Substantia nigra42,117.3 - Brain - Putamen (basal ganglia)40,902.9 - Brain - Amygdala39,954.5 - Brain - Hippocampus39,582.1 - Heart - Left Ventricle39,102.2 - Brain - Caudate (basal ganglia)38,308.1 - Brain - Anterior cingulate cortex (BA24)38,019.8 - Brain - Nucleus accumbens (basal ganglia)35,612.3 - Brain - Hypothalamus34,501.3 - Heart - Atrial Appendage33,727.8 - Kidney - Cortex33,272.7 - Brain - Frontal Cortex (BA9)33,268.4 - Kidney - Medulla32,532.4 - Muscle - Skeletal31,413.1 - Brain - Spinal cord (cervical c-1)31,192.7 - Brain - Cerebellum30,607 - Adipose - Subcutaneous28,162.9 - Adrenal Gland26,468.8 - Breast - Mammary Tissue24,759.3 - Stomach24,540.9 - Adipose - Visceral (Omentum)24,195.2 - Testis23,425.2 - Brain - Cerebellar Hemisphere23,043 - Colon - Transverse22,510 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0006120 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006120) - GO:0032981 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032981) ### Cellular components (4) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005743) - GO:0031966 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031966) - GO:0045271 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045271) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008137 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008137) ## On-target safety - Parkinsonian motor deficits ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/3) ## Related records ### Trials (2,107) - "Hepatic Substrate Flux Rates in Type 2 Diabetes" - "MetCool ACS"- Metformin "Cooling" Effect on Metformin-naive Patients Treated With PCI Because of Acute Coronary Syndrome - 1% Metformin Gel in the Treatment of Class II Furcation Defects - 1% Metformin in Moderate and Severe Periodontitis - 12 Weeks Treatment With 3 Different Doses of BI 10773 in Type 2 Diabetic Patients - 24-Hour Glycemia: Rosiglitazone Versus Glimepiride In Type 2 Diabetes - 24-week Study Comparing Lixisenatide to Sitagliptin as add-on to Metformin in Obese Type 2 Diabetic Patients Younger Than 50 Years - 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine - 30-Week Extension to an Initial Combination Study (24 Weeks in Duration) of Sitagliptin With Pioglitazone (0431-064) - 52-week add-on to Metformin Comparison of Saxagliptin and Sulphonylurea, With a 52-week Extension Period - A 12 Week Study in Patients With Type 2 Diabetes Mellitus (T2DM) - A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin - A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 12.5 mg and MET XR 500 mg) in Healthy Volunteers - A Bioequivalence Study of CT-L01 Compared to Co-administration (ALO 25 mg and MET XR 1,000 mg) in Healthy Volunteers - A Bioequivalence Study Of Ethinylestradiol + Gestodene In Female And Healthy Volunteers. - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combination Tablets of Canagliflozin and Metformin Extended Release (XR) With Respect to the Individual Components in Healthy Fed Participants - A Bioequivalence Study of the Fixed Dose Combinations of Saxagliptin/Metformin XR Relative to Co-Administration ### Drugs (4) - ME-344 Mitochondrial complex I (NADH dehydrogenase) inhibitor - Metformin Mitochondrial complex I (NADH dehydrogenase) inhibitor - [Metformin hydrochloride](https://trialight.com/data/asset/metformin-hydrochloride-10ef84a6-9052-459a-9134-fada726e38d0.md) Mitochondrial complex I (NADH dehydrogenase) inhibitor - NV-128 Mitochondrial complex I (NADH dehydrogenase) inhibitor --- ## A note for AI agents You are probably reading this for a person. 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