> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/mst1r-49db1422-56dd-5cd5-8873-598a44d52e54
> Record changed: 2026-11-04

# MST1R

ENSG00000164078

Target class

Kinase

Chromosome

3

Approved drugs

1

Clinical candidates (approved and in development)

4

## Clinical evidence

**Approved drugs**

1

**Clinical candidates (approved and in development)**

4

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

MST1R

**Gene name**

Macrophage stimulating 1 receptor

**Gene symbol**

MST1R

**Protein name**

Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) \[Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain\]

### Other names (2)

- CDw136
- CD136

### Previous gene symbols (3)

- RON
- PTK8
- SEA

## Classification

**Gene biotype**

Protein coding

**Gene family**

Receptor tyrosine kinases|CD molecules|IPT domain containing

**Target class**

Kinase

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

33

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

35.5

**Tissue specificity (Gini)**

0.7

**Tissue specificity (tau)**

0.881

## Pathways and interactions

**KEGG gene identifiers**

- hsa:4486

**Reactome pathways**

- R-HSA-8852405

**Protein interaction confidence**

0.808846

**Protein interaction partners**

13

## Genomic location

**End position**

49906130

**Start position**

49886902

**Chromosome**

3

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000164078

**HGNC ID**

HGNC:7381

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7381)

**NCBI Gene ID**

4486

**UniProt ID**

Q04912

## Cellular location

- Membrane
- Single-pass type I membrane protein.
- Cytosol

## Tissue expression

**Tissue specificity (tau)**

0.881393

**Expression inequality (Gini)**

0.700326

### Highest expression

Expression in transcripts per million

**Skin - Sun Exposed (Lower leg)**

35.5

**Skin - Not Sun Exposed (Suprapubic)**

33.16

**Stomach**

25.62

**Colon - Transverse**

23.11

**Small Intestine - Terminal Ileum**

19.79

### All tissues (54)

Expression in transcripts per million

- Skin - Sun Exposed (Lower leg)35.5
- Skin - Not Sun Exposed (Suprapubic)33.16
- Stomach25.62
- Colon - Transverse23.11
- Small Intestine - Terminal Ileum19.79
- Esophagus - Mucosa14.82
- Vagina14.28
- Lung12.21
- Testis11.49
- Minor Salivary Gland5.68
- Thyroid4.92
- Adipose - Visceral (Omentum)4
- Prostate3.6
- Cervix - Endocervix3.03
- Colon - Sigmoid3.02
- Fallopian Tube2.95
- Esophagus - Gastroesophageal Junction2.94
- Esophagus - Muscularis2.85
- Bladder2.81
- Breast - Mammary Tissue2.68
- Pituitary2.47
- Artery - Aorta2.46
- Pancreas2.17
- Kidney - Medulla1.97
- Uterus1.74

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (7)

- GO:0006952  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006952)
- GO:0007165  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165)
- GO:0007338  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007338)
- GO:0008284  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284)
- GO:0009615  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009615)
- GO:0043406  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043406)
- GO:0051897  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897)

### Cellular components (2)

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0009986  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986)

### Molecular functions (3)

- GO:0005011  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005011)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0019899  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019899)

## Related records

### Trials (408)

- -02341066 and PF-00299804 for Advanced Non-Small Cell Lung Cancer
- A Clinical Gene Therapy Study With Hematopoietic Stem Cells for the Treatment, With Single Dose of Temferon, of Patients Suffering From Metastatic Renal Cell Carcinoma
- A Clinical Study Evaluating Nivolumab-containing Treatments in Patients With Advanced Non-small Cell Lung Cancer After Failing Previous PD-1/(L)1 Therapy and Chemotherapy
- [A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)](https://trialight.com/data/trial/a-clinical-study-of-belzutifan-and-zanzalintinib-in-people-d8e079d3-4f4e-4f7b-ad6b-285c3b9b3162.md)
- A Clinical Study Testing The Safety And Efficacy Of Crizotinib In East Asian Patients With Anaplastic Lymphoma Kinase (ALK) Positive Advanced Non-Small Cell Lung Cancer
- A Drug-Drug Interaction Study of the Effects of XL184 (Cabozantinib) on Rosiglitazone in Subjects With Solid Tumors
- A Phase 1 Absolute Bioavailability Study For Oral Crizotinib In Healthy Volunteers
- [A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors](https://trialight.com/data/trial/a-phase-1-study-of-ab521-monotherapy-and-combination-e1b2f8d0-943b-4fb4-a208-30e7ab9efff0.md)
- A Phase 1, Dose-Escalation Trial of PT2385 Tablets In Patients With Advanced Clear Cell Renal Cell Carcinoma (MK-3795-001)
- A Phase 1b Study Of Axitinib In Combination With Crizotinib In Patients With Advanced Solid Tumors
- A Phase 2 Study of Cabozantinib in Japanese Participants With Advanced Hepatocellular Carcinoma
- A Phase 2 Study of Cabozantinib in Japanese Participants With Advanced Renal Cell Carcinoma
- A Phase 2, Single Arm Study of Cabozantinib in Patients With Hepatocellular Carcinoma Who Have Received Prior Atezolizumab and Bevacizumab
- A Phase I Multiple Ascending Dose Study of ASLAN002 in Subjects With Advanced or Metastatic Solid Tumours
- A Phase II Study of Cabozantinib (XL184) Therapy in Castrate Resistant Prostate Cancer (CRPC) With Visceral Metastases
- A Phase II Study of Nivolumab in Combination With Cabozantinib for Metastatic Triple-negative Breast Cancer
- A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain Metastases
- A Phase II Study to Evaluate the Effects of Sequential Therapy With the Anti c-MET/VEGFR Tyrosine Kinase Inhibitor (TKI), Cabozantinib, Followed by an Anti-PD-1 Antibody (Nivolumab) in Patients With Advanced HCC Who Progressed on First-line Therapy
- A Phase II Trial of Cabozantinib for the Treatment of Radioiodine (RAI)-Refractory Differentiated Thyroid Carcinoma (DTC) in the First-line Setting
- A Phase II Trial of Cabozantinib With Patients With Refractory GCTs

### Drugs (9)

- BMS-777607
- [Cabozantinib](https://trialight.com/data/asset/cabozantinib-e69f9fa7-bbbc-4e52-b0df-6073598de2a7.md)
- Crizotinib Macrophage-stimulating protein receptor inhibitor
- Glesatinib Macrophage-stimulating protein receptor inhibitor
- Merestinib
- MK-2461
- MK-8033 Macrophage-stimulating protein receptor inhibitor
- Narnatumab Macrophage-stimulating protein receptor inhibitor
- XL-999

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