> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ms4a1-9e34d7a7-7b3d-5f02-928a-d18d9b50c1f8 > Record changed: 2026-10-13 # MS4A1 ENSG00000156738 Target class Ion channel Chromosome 11 Approved drugs 10 Clinical candidates (approved and in development) 18 ## Clinical evidence **Approved drugs** 10 **ClinGen gene-disease validity** Limited **Clinical candidates (approved and in development)** 18 ## Druggability **Chemical probe available** No ## Names **Target name** MS4A1 **Gene name** Membrane spanning 4-domains A1 **Gene symbol** MS4A1 **Previous gene symbols** - CD20 **Protein name** B-lymphocyte antigen CD20 (B-lymphocyte surface antigen B1) (Bp35) (Leukocyte surface antigen Leu-16) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20) ### Other names (3) - B1 - Bp35 - FMC7 ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Membrane spanning 4-domains **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 8 **Protein localisation evidence grade** Supported **Highest tissue expression** 556.66 **Tissue specificity (Gini)** 0.955 **Tissue specificity (tau)** 0.988 ## Pathways and interactions **KEGG gene identifiers** - hsa:931 **Protein interaction confidence** 0.805643 **Protein interaction partners** 28 ## Genomic location **End position** 60470752 **Start position** 60455752 **Chromosome** 11 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000156738 **HGNC ID** HGNC:7315 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7315) **NCBI Gene ID** 931 **UniProt ID** P11836 ## Cellular location - Cell membrane - Multi-pass membrane protein . Cell membrane - Lipid-anchor . Note=Constitutively associated with membrane rafts. . - Plasma membrane ### Publication evidence (2) - PubMed 12920111 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12920111/) - PubMed 22615937 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22615937/) ## Tissue expression **Tissue specificity (tau)** 0.988393 **Expression inequality (Gini)** 0.955436 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 556.66 **Spleen** 267.81 **Small Intestine - Terminal Ileum** 46.03 **Whole Blood** 10.68 **Lung** 3.49 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes556.66 - Spleen267.81 - Small Intestine - Terminal Ileum46.03 - Whole Blood10.68 - Lung3.49 - Esophagus - Mucosa1.43 - Colon - Transverse1.36 - Testis1.1 - Thyroid0.75 - Adipose - Visceral (Omentum)0.72 - Kidney - Cortex0.71 - Liver0.6 - Stomach0.51 - Fallopian Tube0.46 - Prostate0.45 - Artery - Coronary0.42 - Minor Salivary Gland0.41 - Nerve - Tibial0.41 - Vagina0.4 - Kidney - Medulla0.39 - Breast - Mammary Tissue0.38 - Cervix - Endocervix0.37 - Adipose - Subcutaneous0.35 - Cervix - Ectocervix0.32 - Bladder0.28 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0002115 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002115) - GO:0030183 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030183) - GO:0042113 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042113) - GO:0050853 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050853) - GO:0051262 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051262) - GO:1902656 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902656) ### Cellular components (5) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0044853 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044853) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (4) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019865 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019865) - GO:0023026 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0023026) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Related records ### Trials (2,793) - "MIRO" Molecularly Oriented Immuno-radio-therapy - \[CREMA\]Combination of R-M Followed by R-A in Elderly Patients With Primary CNS Lymphoma - 131I-rituximab for Relapsed or Refractory Follicular or Mantle Cell Lymphoma - 131I-rituximab for Relapsed or Refractory Marginal Zone B-cell Lymphoma - 17-N-Allylamino-17-Demethoxygeldanamycin With or Without Rituximab in Treating Patients With Relapsed B-Cell Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia - 9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis - 90Y-IBRITUMOMAB Tiuxetan and AHCI With HD Chemotherapy and Autologous Transplantation for Relapsed or Resistant NHL - A 12 Week Randomized Open Label Parallel Group Multicenter Study to Evaluate Bioequivalence of 20 mg Subcutaneous Ofatumumab Injected by Pre-filled Syringe or Autoinjector in Adult RMS Patients - [A Biosimilar Trial to Investigate PK, PD, Safety With PB018 Versus US-licensed Ocrevus and EU-approved Ocrevus](https://trialight.com/data/trial/a-biosimilar-trial-to-investigate-pk-pd-safety-with-pb018-b24aa56f-400c-4fb2-ad12-8469072f687d.md) - A Clinical Study of Hanlikang and BTK Inhibitors in the Treatment of Newly Diagnosed Mantle Cell Lymphoma - [A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)](https://trialight.com/data/trial/a-clinical-study-of-zilovertamab-vedotin-mk-2140-plus-134b8f98-3329-4e9d-af03-b73bfdbc1295.md) - A Clinical Study Using MEDI-551 in Adult Participants With Relapsed or Refractory Advanced B-Cell Malignancies - [A Clinical Trial of MK-1045 and Rituximab in People With Follicular Lymphoma (MK-1045-007)](https://trialight.com/data/trial/a-clinical-trial-of-mk-1045-and-rituximab-in-people-with-3c20ff0c-d021-4948-bdbc-f32491858aae.md) - A Clinical Trial to Evaluate the Efficacy and Safety of TQB3909 Tablets Versus Investigator's Choice in the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) - A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312) - A Combination of Rituximab and CC-99282 as Front-line Therapy for Older Frail Patients With Diffuse Large B-cells Non-Hodgkin Lymphoma Evaluated With a Simplified Geriatric Assessment (sGA): a Phase II Study of the Fondazione Italiana Linfomi (FIL) - [A Comparative Study of Pharmacokinetics, Pharmacodynamics, Safety, and Immunogenicity of RPH-035 and Ocrevus® in Patients With Relapsing-remitting or Secondary Progressive Multiple Sclerosis With Exacerbations](https://trialight.com/data/trial/a-comparative-study-of-pharmacokinetics-pharmacodynamics-7d8975ad-fa8e-4f89-8e3a-353029511070.md) - A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma - A Compassionate Use (CU) Program of Odronextamab - A Dose Escalation Study of Glofitamab (RO7082859) as a Single Agent and in Combination With Obinutuzumab, Administered After a Fixed, Single Pre-treatment Dose of Obinutuzumab in Participants With Relapsed/Refractory B-cell Non-hodgkin's Lymphoma ### Drugs (18) - [Epcoritamab](https://trialight.com/data/asset/epcoritamab-90c61ada-445b-4582-bc08-34253c4199d1.md) B-lymphocyte antigen CD20 binding agent - FBT-A05 B-lymphocyte antigen CD20 cross-linking agent - [Glofitamab](https://trialight.com/data/asset/glofitamab-7a0dacb2-d6fd-4eee-b1db-3e6e7c33c79d.md) B-lymphocyte antigen CD20 binding agent - LFB-R603 B-lymphocyte antigen CD20 binding agent - [Mosunetuzumab](https://trialight.com/data/asset/mosunetuzumab-aa4ba629-2b3d-40cc-9deb-ebec509a71eb.md) B-lymphocyte antigen CD20 binding agent - MT-3724 B-lymphocyte antigen CD20 binding agent - [Obinutuzumab](https://trialight.com/data/asset/obinutuzumab-1aa4994f-1407-4a89-93f0-0b3aa295ad6e.md) B-lymphocyte antigen CD20 binding agent - Ocaratuzumab B-lymphocyte antigen CD20 binding agent - [Ocrelizumab](https://trialight.com/data/asset/ocrelizumab-88f6b89d-011b-4db2-af88-51414e00e847.md) B-lymphocyte antigen CD20 binding agent - Odronextamab B-lymphocyte antigen CD20 binding agent - Ofatumumab B-lymphocyte antigen CD20 binding agent - [Rituximab](https://trialight.com/data/asset/rituximab-3fb73477-f618-414e-aa0a-9ccba4d6da3f.md) B-lymphocyte antigen CD20 binding agent - Tositumomab B-lymphocyte antigen CD20 binding agent - Tositumomab 131I B-lymphocyte antigen CD20 binding agent - TRU-015 B-lymphocyte antigen CD20 binding agent - [Ublituximab](https://trialight.com/data/asset/ublituximab-3c9899a4-b048-41b6-a488-c8af00eca6d3.md) B-lymphocyte antigen CD20 binding agent - Veltuzumab B-lymphocyte antigen CD20 binding agent - Yttrium Y 90 ibritumomab tiuxetan B-lymphocyte antigen CD20 binding agent --- ## A note for AI agents You are probably reading this for a person. 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