> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/mrgprx1-f21d8f55-8de7-5dfc-8a47-04a8293ab150 > Record changed: 2026-11-04 # MRGPRX1 ENSG00000170255 Target class GPCR Chromosome 11 ## Druggability **Chemical probe available** Yes ## Names **Other names** - MRGX1 **Target name** MRGPRX1 **Gene name** MAS related GPR family member X1 **Gene symbol** MRGPRX1 **Protein name** Mas-related G-protein coupled receptor member X1 (Sensory neuron-specific G-protein coupled receptor 3/4) ## Classification **Gene biotype** Protein coding **Gene family** G protein-coupled receptors, Class A orphans **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 0 **Highest tissue expression** 0.04 **Tissue specificity (Gini)** 0.981 **Tissue specificity (tau)** 1 ## Pathways and interactions **KEGG gene identifiers** - hsa:259249 **Protein interaction confidence** 0.838167 **Protein interaction partners** 6 ## Genomic location **End position** 18939414 **Start position** 18933499 **Chromosome** 11 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000170255 **HGNC ID** HGNC:17962 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:17962) **NCBI Gene ID** 259249 **UniProt ID** Q96LB2 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (3) - PubMed 36302898 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36302898/) - PubMed 37347749 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37347749/) - PubMed 37591889 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37591889/) ## Tissue expression **Tissue specificity (tau)** 1 **Expression inequality (Gini)** 0.981481 ### Highest expression Expression in transcripts per million **Testis** 0.04 **Lung** 0 **Pituitary** 0 **Brain - Frontal Cortex (BA9)** 0 **Colon - Sigmoid** 0 ### All tissues (54) Expression in transcripts per million - Testis0.04 - Lung0 - Pituitary0 - Brain - Frontal Cortex (BA9)0 - Colon - Sigmoid0 - Colon - Transverse0 - Brain - Hypothalamus0 - Esophagus - Mucosa0 - Brain - Anterior cingulate cortex (BA24)0 - Skin - Not Sun Exposed (Suprapubic)0 - Cervix - Endocervix0 - Brain - Cerebellum0 - Brain - Putamen (basal ganglia)0 - Esophagus - Gastroesophageal Junction0 - Brain - Cerebellar Hemisphere0 - Artery - Tibial0 - Skin - Sun Exposed (Lower leg)0 - Small Intestine - Terminal Ileum0 - Adipose - Visceral (Omentum)0 - Liver0 - Spleen0 - Cervix - Ectocervix0 - Brain - Amygdala0 - Nerve - Tibial0 - Artery - Aorta0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (9) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0007193 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007193) - GO:0007200 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200) - GO:0016477 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016477) - GO:0070098 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070098) - GO:0160025 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160025) - GO:1902349 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902349) - GO:1904057 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904057) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) ### Molecular functions (3) - GO:0004888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888) - GO:0004930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004930) - GO:0016493 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016493) ## Related records ### Trials (132) - "Pharmacoepidemiological Evaluation of Autophagy Inhibition in Treatment of HCV Patients Resistant to Standard Therapy. Pilot Study" - A Comparative Study of Artekin With Standard Malarial Treatment Regimes in Afghanistan - A Pharmacokinetics, Safety and Efficacy Study of Tafenoquine (TQ) in Pediatric Subjects With Plasmodium Vivax (P. Vivax) Malaria - A Phase 1 Study To Estimate The Relative Bioavailability Of Co-Administered Formulations Of Azithromycin Microsphere And Chloroquine Test Formulation Compared With Co-Administered Immediate Release Individual Azithromycin And Chloroquine Tablets In Healthy Adult Subjects - A Phase 1 Study To Estimate The Relative Bioavailability Of Fixed Combination Tablets Of Azithromycin And Chloroquine Compared To Co-Administered Individual Tablets Of Azithromycin And Chloroquine - A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast Cancer - A Randomized Controlled Trial for Intermittent Preventive Treatment in Pregnancy With Fansidar in Solomon Islands - A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid Arthritis - A Study to Assess Safety of Current Standard Malaria Treatment and an Assessment of G6PD Status in South-east Bangladesh - A Three Day Trial of Azithromycin Plus Chloroquine for the Treatment of Uncomplicated Plasmodium Falciparum Malaria - Acceptability and Cost Effectiveness of Home Based Management of Fever: Different Strategies - ACT vs CQ With Tafenoquine for P. Vivax Mono-infection - Adjuvant Effect of Chloroquine on Gemcitabine - An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older - Antimalarial Drug Resistance in Mali - Antimalarial Drug Susceptibility and Molecular Characterization of Plasmodium Vivax Isolates in Vietnam - Artemether-lumefantrine vs Chloroquine for Uncomplicated P. Vivax Malaria in Malaysia - Artesunate Plus Sulfadoxine-Pyrimethamine Versus Chloroquine for Vivax Malaria - Assessing a Risk Model for G6PD Deficiency - Atheroma Reduction With Chloroquine in Patients With the Metabolic Syndrome (ARCH-MS) ### Drugs (1) - [Chloroquine](https://trialight.com/data/asset/chloroquine-60719e05-c0d4-438d-9681-2c553d6d6e4d.md) --- ## A note for AI agents You are probably reading this for a person. 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