> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/mpo-a349ca0c-13c2-5928-8093-e1d7f3eea5a1 > Record changed: 2026-11-04 # MPO ENSG00000005381 Target class Enzyme Chromosome 17 Approved drugs 0 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** No ## Names **Target name** MPO **Gene name** Myeloperoxidase **Gene symbol** MPO **Protein name** Myeloperoxidase (MPO) (EC 1.11.2.2) \[Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain\] ## Classification **Gene biotype** Protein coding **Gene family** Heme peroxidase family **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 12 **Protein localisation evidence grade** Supported **Highest tissue expression** 21.28 **Tissue specificity (Gini)** 0.732 **Tissue specificity (tau)** 0.957 ## Pathways and interactions **KEGG gene identifiers** - hsa:4353 **Protein interaction confidence** 0.822959 **Protein interaction partners** 74 ### Reactome pathways (2) - R-HSA-6798695 - R-HSA-8941413 ## Genomic location **End position** 58280935 **Start position** 58269855 **Chromosome** 17 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000005381 **HGNC ID** HGNC:7218 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7218) **NCBI Gene ID** 4353 **UniProt ID** P05164 ## Cellular location - Lysosome. - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.956962 **Expression inequality (Gini)** 0.731765 ### Highest expression Expression in transcripts per million **Whole Blood** 21.28 **Spleen** 13.19 **Lung** 6.57 **Pituitary** 2.56 **Minor Salivary Gland** 2.06 ### All tissues (54) Expression in transcripts per million - Whole Blood21.28 - Spleen13.19 - Lung6.57 - Pituitary2.56 - Minor Salivary Gland2.06 - Brain - Frontal Cortex (BA9)1.75 - Brain - Cortex1.74 - Brain - Cerebellum1.29 - Brain - Anterior cingulate cortex (BA24)1.22 - Testis1.19 - Brain - Hypothalamus1.08 - Brain - Cerebellar Hemisphere1.07 - Brain - Putamen (basal ganglia)0.93 - Brain - Caudate (basal ganglia)0.88 - Brain - Substantia nigra0.87 - Brain - Nucleus accumbens (basal ganglia)0.82 - Brain - Hippocampus0.82 - Brain - Amygdala0.78 - Muscle - Skeletal0.7 - Artery - Aorta0.61 - Brain - Spinal cord (cervical c-1)0.6 - Thyroid0.49 - Breast - Mammary Tissue0.48 - Adipose - Visceral (Omentum)0.47 - Liver0.44 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (11) - GO:0006337 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006337) - GO:0006952 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006952) - GO:0006979 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006979) - GO:0034374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034374) - GO:0042744 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042744) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0070943 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070943) - GO:0070944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070944) - GO:0070947 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070947) - GO:0140645 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140645) - GO:1904109 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904109) ### Cellular components (10) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005764 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005764) - GO:0030141 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030141) - GO:0035578 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035578) - GO:0042582 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042582) - GO:0045335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045335) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0097013 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097013) - GO:0140644 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140644) ### Molecular functions (6) - GO:0003682 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003682) - GO:0004601 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004601) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008201 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008201) - GO:0031491 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031491) - GO:0140776 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140776) ## Related records ### Trials (29) - A Phase I, Safety Tolerability and Pharmacokinetics of AZD4831 to Treat Cardiovascular Disease - A Study in Participants With Non-cirrhotic NASH With Fibrosis - A Study to Assess Safety and Tolerability of Oral AZD3241 in Patients With Parkinson's Disease - A Study to Assess the Effect AZD4831 in Japanese and Chinese Healthy Volunteers - A Study to Assess the Mass Balance Recovery, Pharmacokinetics, Metabolite Profile and Metabolite Identification of \[14C\]AZD4831 - A Study to Assess the Pharmacokinetics (Uptake of Drugs by the Body), Safety and Tolerability of AZD4831 in Participants With Severe Renal Impairment and Healthy Volunteers - A Study to Assess the Pharmacokinetics of AZD4831 When Administered Alone and in Combination With Itraconazole - A Study to Assess the Relative Bioavailability and Safety of Different Formulations of AZD4831 in Fasted State in Healthy Volunteers. - A Study to Assess the Safety and Tolerability of Single and Multiple Doses of AZD4831 in Healthy Male Subjects - A Study To Assess The Safety, Tolerability And Pharmacokinetics Of PF-06282999 Administered Orally In Healthy Adult Subjects - A Study To Evaluate The Safety And Effects On The Body Of An Investigational Drug Using An Endotoxin-Induced Inflammatory Response Model - A Study To Test The Safety, Amount And Effects Of PF-06282999 In Healthy Overweight Adults And A Study To Test The Effects Of PF-06282999 On The Amount Of The Approved Drug, Midazolam, In Healthy Adults - [An Efficacy and Safety Study of Mitiperstat (AZD4831) (MPO Inhibitor) vs Placebo in the Treatment of Moderate to Severe COPD.](https://trialight.com/data/trial/an-efficacy-and-safety-study-of-mitiperstat-azd4831-mpo-5ee89c73-90a3-4a43-8d96-033bec5155d4.md) - AZD3241 PET MSA Trial, Phase 2, Randomized,12 Week Safety and Tolerability Trial With PET in MSA Patients - Effect of Verdiperstat on Microglial Activation in Well-characterized MSA Patients - Expanded Access Protocol of Verdiperstat in Patients With Multiple System Atrophy (MSA) - HEALEY ALS Platform Trial - Master Protocol - HEALEY ALS Platform Trial - Regimen B Verdiperstat - Investigating Safety, Tolerability and Pharmakinetics When Giving Single and Fractionated Doses of AZD3241 to Healthy Volunteers - Myeloperoxidase (MPO) Inhibitor A\_Zeneca for Heart Failure With Preserved Ejection Fraction (HFpEF) ### Drugs (3) - [Mitiperstat](https://trialight.com/data/asset/mitiperstat-bdc25dd1-b024-4111-8018-788c44a6e9e7.md) - PF-06282999 - Verdiperstat Myeloperoxidase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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