> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/mpc2-f055153a-b729-528c-ad6b-c55eaa11a1ac > Record changed: 2026-11-04 # MPC2 ENSG00000143158 Target class Transporter Chromosome 1 ## Druggability **Chemical probe available** No ## Names **Target name** MPC2 **Gene name** Mitochondrial pyruvate carrier 2 **Gene symbol** MPC2 **Previous gene symbols** - BRP44 **Protein name** Mitochondrial pyruvate carrier 2 (Brain protein 44) ### Other names (2) - DKFZP564B167 - SLC54A2 ## Classification **Gene biotype** Protein coding **Gene family** Solute carrier family 54, mitochondrial pyruvate carriers **Target class** Transporter **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 165.04 **Tissue specificity (Gini)** 0.231 **Tissue specificity (tau)** 0.754 ## Pathways and interactions **KEGG gene identifiers** - hsa:25874 **Reactome pathways** - R-HSA-70268 **Protein interaction confidence** 0.9415 **Protein interaction partners** 2 ## Genomic location **End position** 167937502 **Start position** 167916675 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000143158 **HGNC ID** HGNC:24515 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:24515) **NCBI Gene ID** 25874 **UniProt ID** O95563 ## Cellular location - Mitochondrion inner membrane - Multi-pass membrane protein . ### Publication evidence (5) - PubMed 22628558 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22628558/) - PubMed 26253029 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26253029/) - PubMed 29472561 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29472561/) - PubMed 40044865 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/40044865/) - PubMed 40101766 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/40101766/) ## Tissue expression **Tissue specificity (tau)** 0.754221 **Expression inequality (Gini)** 0.23114 ### Highest expression Expression in transcripts per million **Testis** 165.04 **Liver** 75.14 **Brain - Frontal Cortex (BA9)** 73.33 **Kidney - Medulla** 70.5 **Stomach** 65.62 ### All tissues (54) Expression in transcripts per million - Testis165.04 - Liver75.14 - Brain - Frontal Cortex (BA9)73.33 - Kidney - Medulla70.5 - Stomach65.62 - Prostate63.14 - Pituitary60.99 - Brain - Cerebellar Hemisphere60.46 - Muscle - Skeletal53.6 - Kidney - Cortex53.45 - Heart - Left Ventricle52.68 - Adrenal Gland52.56 - Brain - Anterior cingulate cortex (BA24)52.33 - Brain - Cortex49 - Brain - Cerebellum48.05 - Cells - EBV-transformed lymphocytes46.87 - Esophagus - Muscularis46.39 - Heart - Atrial Appendage46.31 - Brain - Nucleus accumbens (basal ganglia)45.9 - Artery - Aorta45.86 - Colon - Transverse45.2 - Brain - Hypothalamus43.81 - Esophagus - Gastroesophageal Junction42.34 - Brain - Caudate (basal ganglia)40.37 - Artery - Coronary40.27 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0006850 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006850) ### Cellular components (4) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005743 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005743) - GO:7770001 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:7770001) ### Molecular functions (2) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) ## Related records ### Trials (104) - \[18F\]F-DOPA Imaging in Patients With Autonomic Failure - A Pilot Comparison of Short-course Nitrofurantoin in Females With Uncomplicated Bacterial Cystitis in the Emergency Department - A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy \[PCNL\]) - A Safety, Tolerability and Levodopa Pharmacokinetics Study of Repeated ND0612 in Parkinson's Disease Patients - A Safety, Tolerability, and Pharmacokinetic Study of ND0612 Delivered as a Continuous Subcutaneous in Parkinson's Disease Patients - A Study to Evaluate Efficacy and Safety of Gepotidacin in the Treatment of Uncomplicated Urinary Tract Infection (UTI) - A Study to Evaluate Fixed Dose Carbidopa/Levodopa/Entacapone Versus Immediate Release Carbidopa/Levodopa - A Study to Investigate the Efficacy and Safety With Gepotidacin in Japanese Female Participants With Uncomplicated Urinary Tract Infection (Acute Cystitis) - An Extension Study of Entacapone in Patients With Parkinson's Disease With End-of-dose Wearing-off. This Study is Not Recruiting in the United States - An Open Clinical Trial of the Safety and Efficacy of the Drug Fluorothiazinone, 300 Mg Tablets with the Participation of Adult Patients with Chronic Bacterial Cystitis" - An Open-Label Feasibility/Pilot Study With \[123I\]-IBZM SPECT (DOPA-SYN) - Antibiotic Prophylaxis and Renal Damage In Congenital Abnormalities of the Kidney and Urinary Tract - Asymptomatic Bacteriuria in Pregnancy in Low- and Middle-IncomE Countries - Augmenting Effects of L-DOPS With Carbidopa and Entacapone - Basic and Clinical Studies of Levodopa/Carbidopa/Entacapone in the Treatment of Early Parkinson's Disease - Behavioral and Physiological Effects of Cocaine in Cocaine-dependent Participants Treated With Levodopa in Combination With Carbidopa and Entacapone (LCE) - Bioequivalence Study of Carbidopa/Levodopa/Entacapone Combination vs. Carbidopa/Levodopa Combination Plus Entacapone in Healthy Volunteers - Bioequivalence Study of Carbidopa/Levodopa/Entacapone Combination vs. Carbidopa/Levodopa Combination Plus Entacapone in Healthy Volunteers - Bioequivalence Study of Carbidopa/Levodopa/Entacapone Combination vs. Carbidopa/Levodopa Combination Plus Entacapone in Healthy Volunteers - Bioequivalence Study of Carbidopa/Levodopa/Entacapone Combination vs. Carbidopa/Levodopa Combination Plus Entacapone Under Fasting Conditions in Healthy Volunteers ### Drugs (4) - Entacapone - Lonidamine - [Nitrofurantoin](https://trialight.com/data/asset/nitrofurantoin-1409e75a-3142-41c2-80b4-5db81a22c2f6.md) - Zaprinast --- ## A note for AI agents You are probably reading this for a person. 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