> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/mmp8-83ced0af-f337-5021-91ee-ae0e6c50d646 > Record changed: 2026-10-13 # MMP8 ENSG00000118113 Target class Enzyme Chromosome 11 Approved drugs 3 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 3 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** Yes ## Names **Target name** MMP8 **Gene name** Matrix metallopeptidase 8 **Gene symbol** MMP8 **Previous gene symbols** - CLG1 **Protein name** Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL) ## Classification **Gene biotype** Protein coding **Gene family** M10 matrix metallopeptidases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 3 **Protein localisation evidence grade** Approved **Highest tissue expression** 49.68 **Tissue specificity (Gini)** 0.943 **Tissue specificity (tau)** 0.994 ## Pathways and interactions **KEGG gene identifiers** - hsa:4317 **Protein interaction confidence** 0.819526 **Protein interaction partners** 19 ### Reactome pathways (4) - R-HSA-1442490 - R-HSA-1474228 - R-HSA-1592389 - R-HSA-6798695 ## Genomic location **End position** 102727050 **Start position** 102711796 **Chromosome** 11 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000118113 **HGNC ID** HGNC:7175 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7175) **NCBI Gene ID** 4317 **UniProt ID** P22894 ## Cellular location - Cytoplasmic granule. Secreted, extracellular space, extracellular matrix . Note=Stored in intracellular granules. - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.994201 **Expression inequality (Gini)** 0.943002 ### Highest expression Expression in transcripts per million **Whole Blood** 49.68 **Spleen** 9.43 **Lung** 2.7 **Adipose - Visceral (Omentum)** 0.31 **Adipose - Subcutaneous** 0.3 ### All tissues (54) Expression in transcripts per million - Whole Blood49.68 - Spleen9.43 - Lung2.7 - Adipose - Visceral (Omentum)0.31 - Adipose - Subcutaneous0.3 - Cells - Cultured fibroblasts0.16 - Testis0.14 - Liver0.12 - Thyroid0.12 - Breast - Mammary Tissue0.12 - Artery - Coronary0.11 - Fallopian Tube0.1 - Pituitary0.1 - Artery - Aorta0.09 - Heart - Atrial Appendage0.09 - Brain - Spinal cord (cervical c-1)0.07 - Brain - Substantia nigra0.07 - Heart - Left Ventricle0.06 - Uterus0.06 - Kidney - Cortex0.06 - Minor Salivary Gland0.06 - Brain - Putamen (basal ganglia)0.06 - Brain - Amygdala0.05 - Brain - Hypothalamus0.05 - Brain - Frontal Cortex (BA9)0.05 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0006508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006508) - GO:0022617 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022617) - GO:0030574 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030574) - GO:0032760 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032760) - GO:0035987 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035987) ### Cellular components (4) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0031012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031012) - GO:0035580 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035580) - GO:1904724 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1904724) ### Molecular functions (6) - GO:0004175 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004175) - GO:0004222 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004222) - GO:0004252 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004252) - GO:0008233 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008233) - GO:0008270 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008270) - GO:0043120 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043120) ## Related records ### Trials (339) - A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India - A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka - A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali - A Clinical Trial of YH14642 in Patients With Chronic Periodontal Disease - A Clinical Trial to Determine the Effects of 40 Mg Doxycycline Versus a Placebo Control for the Treatment of Rosacea - A Clinico-Pathological Study to Investigate the Possible Infective Causes of Non-Hodgkin Lymphoma of the Ocular Adnexae - A Comparative Study on Ivermectin and Hydroxychloroquine on the COVID19 Patients in Bangladesh - A Controlled Study to Assess the Efficacy, Safety and Tolerability of Oral DFD-29 Extended Release Capsules - A Novel Combination Oral Agent to Treat Acne Vulgaris - A Phase II Study of Doxycycline in Relapsed NHL - A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity - A Pilot Study of Inflammatory Markers in Alzheimer's Disease - A Randomized Controlled Trial of Doxycycline Post Exposure Prophylaxis to Prevent Incident Bacterial STIs Among Women in the United States - A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions - A Randomized, Double-Blind Study to Assess the Safety, Efficacy and Tolerability of Oral DFD-29 Capsules for the Treatment of Rosacea. - A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seronegative Chronic Lyme Disease - A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of the Safety and Efficacy of Ceftriaxone and Doxycycline in the Treatment of Patients With Seropositive Chronic Lyme Disease - A Randomized, Placebo-Controlled Trial of BMS-275291 Given Daily for 12 Months to Women With Stage 1c-IIIA Breast Cancer Receiving Adjuvant Chemotherapy and/or Hormonal Therapy - A Study Comparing Doxycycline and Levofloxacin for Treating COPD Exacerbations - A Study of ALTY-0501 for the Treatment of Dry Eye Administered 4 Times a Day for a 56 Day Period ### Drugs (6) - CTS-1027 Matrix metalloproteinase 8 inhibitor - [Doxycycline](https://trialight.com/data/asset/doxycycline-9994da3d-bd1e-4dba-9a9e-392765b5aa58.md) Matrix metalloproteinase 8 inhibitor - Doxycycline anhydrous Matrix metalloproteinase 8 inhibitor - Doxycycline calcium Matrix metalloproteinase 8 inhibitor - Doxycycline hyclate Matrix metalloproteinase 8 inhibitor - Rebimastat Matrix metalloproteinase 8 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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