MMP1

ENSG00000196611
Target class
Enzyme
Chromosome
11
Approved drugs
3
Clinical candidates (approved and in development)
5

Approved drugs
3
Clinical candidates (approved and in development)
5

Chemical probe available
Yes

Target name
MMP1
Gene name
Matrix metallopeptidase 1
Gene symbol
MMP1
Previous gene symbols
  • CLG
Protein name
Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]

Gene biotype
Protein coding
Gene family
Receptor ligands|M10 matrix metallopeptidases
Target class
Enzyme
Target type
Human gene

Tissues expressed in
6
Protein localisation evidence grade
Approved
Highest tissue expression
51.85
Tissue specificity (Gini)
0.928
Tissue specificity (tau)
0.991

KEGG gene identifiers
  • hsa:4312
Protein interaction confidence
0.804591
Protein interaction partners
44

  • R-HSA-1442490
  • R-HSA-1474228
  • R-HSA-1592389
  • R-HSA-210991
  • R-HSA-381426
  • R-HSA-6785807

End position
102798160
Start position
102789401
Chromosome
11
Strand
Reverse

Ensembl gene ID
ENSG00000196611
HGNC ID
HGNC:7155
www.genenames.org
NCBI Gene ID
4312
UniProt ID
P03956

  • Secreted, extracellular space, extracellular matrix .
  • Vesicles

Publication evidence

Tissue specificity (tau)
0.991077
Expression inequality (Gini)
0.92813

Expression in transcripts per million

Cells - Cultured fibroblasts
51.85
Stomach
10.15
Spleen
3
Small Intestine - Terminal Ileum
2.38
Lung
2.29

Expression in transcripts per million

  • Cells - Cultured fibroblasts51.85
  • Stomach10.15
  • Spleen3
  • Small Intestine - Terminal Ileum2.38
  • Lung2.29
  • Kidney - Medulla1.46
  • Colon - Transverse0.81
  • Minor Salivary Gland0.67
  • Kidney - Cortex0.52
  • Bladder0.48
  • Testis0.32
  • Pancreas0.29
  • Esophagus - Mucosa0.16
  • Adipose - Subcutaneous0.16
  • Artery - Aorta0.14
  • Thyroid0.14
  • Artery - Coronary0.13
  • Prostate0.13
  • Skin - Sun Exposed (Lower leg)0.12
  • Vagina0.1
  • Adipose - Visceral (Omentum)0.09
  • Breast - Mammary Tissue0.09
  • Fallopian Tube0.08
  • Whole Blood0.08
  • Skin - Not Sun Exposed (Suprapubic)0.08

And 29 more, listed on the interactive page.

Cellular components

  • regulation of transcription factor activity

    Studies

    • cell-based: LTEA_HepaRG_MMP1is one of 100 assay component(s) measured in the LTEA HepaRG cell culture assay. It is a marker of Fibrosis.

    Biological samples

    • HepaRG, cell line
    Evidence source
    www.epa.gov

  • regulation of catalytic activity

    Studies

    • biochemical: NVS_ENZ_hMMP1, is one of one assay component(s) measured or calculated from the NVS_ENZ_hMMP1 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence technology.

    Biological samples

    • cell-free
    Evidence source
    www.epa.gov

  • regulation of gene expression

    • cell-based: BSK_BE3C_MMP1, is one of 11 assay component(s) measured or calculated from the BSK_BE3C assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology.
    • cell-based: BSK_hDFCGF_MMP1, is one of 12 assay component(s) measured or calculated from the BSK_hDFCGF assay. It is designed to make measurements of enzyme-linked immunosorbent assay, a form of binding reporter, as detected with fluorescence intensity signals by Enzyme-linked immunosorbent assay technology.

    • bronchial epithelial cells, primary cell
    • foreskin fibroblast, primary cell
    Evidence source
    www.epa.gov

Related records

Trials (340)

Drugs (6)