> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/mme-0b31afed-f137-5b07-94ce-16ae0679e175 > Record changed: 2026-10-13 # MME ENSG00000196549 Target class Enzyme Chromosome 3 Approved drugs 1 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 1 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** No ## Names **Target name** MME **Gene name** Membrane metalloendopeptidase **Gene symbol** MME **Protein name** Neprilysin (EC 3.4.24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (Enkephalinase) (Neutral endopeptidase 24.11) (NEP) (Neutral endopeptidase) (Skin fibroblast elastase) (SFE) (CD antigen CD10) ### Other names (3) - CALLA - CD10 - NEP ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|M13 metallopeptidases|Elastases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 29 **Protein localisation evidence grade** Approved **Highest tissue expression** 640.48 **Tissue specificity (Gini)** 0.894 **Tissue specificity (tau)** 0.991 ## Pathways and interactions **KEGG gene identifiers** - hsa:4311 **Protein interaction confidence** 0.814414 **Protein interaction partners** 58 ### Reactome pathways (4) - R-HSA-2022377 - R-HSA-5578768 - R-HSA-6798695 - R-HSA-9927432 ## Genomic location **End position** 155183803 **Start position** 155024124 **Chromosome** 3 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000196549 **HGNC ID** HGNC:7154 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7154) **NCBI Gene ID** 4311 **UniProt ID** P08473 ## Cellular location - Cell membrane - Single-pass type II membrane protein . - Plasma membrane ### Publication evidence - PubMed 20876573 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20876573/) ## Tissue expression **Tissue specificity (tau)** 0.991303 **Expression inequality (Gini)** 0.893758 ### Highest expression Expression in transcripts per million **Cells - Cultured fibroblasts** 640.48 **Nerve - Tibial** 42.94 **Kidney - Cortex** 37.73 **Prostate** 24.75 **Adipose - Subcutaneous** 24.01 ### All tissues (54) Expression in transcripts per million - Cells - Cultured fibroblasts640.48 - Nerve - Tibial42.94 - Kidney - Cortex37.73 - Prostate24.75 - Adipose - Subcutaneous24.01 - Breast - Mammary Tissue22.29 - Whole Blood22.18 - Lung20.28 - Small Intestine - Terminal Ileum17.72 - Adipose - Visceral (Omentum)11.21 - Vagina7.78 - Muscle - Skeletal7.76 - Brain - Caudate (basal ganglia)5.84 - Liver5.81 - Kidney - Medulla5.6 - Minor Salivary Gland5.14 - Brain - Putamen (basal ganglia)4.33 - Esophagus - Gastroesophageal Junction2.76 - Spleen2.47 - Cervix - Ectocervix2.22 - Artery - Coronary2.07 - Bladder2.03 - Cervix - Endocervix1.84 - Fallopian Tube1.58 - Brain - Nucleus accumbens (basal ganglia)1.48 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (15) - GO:0001822 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001822) - GO:0006508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006508) - GO:0007611 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007611) - GO:0010814 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010814) - GO:0010815 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010815) - GO:0042447 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042447) - GO:0046449 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046449) - GO:0050769 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050769) - GO:0061837 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061837) - GO:0071345 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071345) - GO:0071492 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071492) - GO:0071493 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071493) - GO:0090399 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090399) - GO:0097242 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097242) - GO:0150094 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0150094) ### Cellular components (13) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005769 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005769) - GO:0005802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005802) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005903 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005903) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0030424 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030424) - GO:0030667 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030667) - GO:0031410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031410) - GO:0043025 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043025) - GO:0045121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) - GO:0098793 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098793) ### Molecular functions (8) - GO:0001786 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001786) - GO:0004175 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004175) - GO:0004222 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004222) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008238 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008238) - GO:0008270 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008270) - GO:0042803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803) - GO:1901612 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901612) ## Related records ### Trials (135) - " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD " - A Bioequivalence Study of Sacubitril/Valsartan Film-coated Tablets Under Fasting Conditions - A Bioequivalence Study of Sacubitril/Valsartan Film-coated Tablets Under Fasting Conditions - A Bioequivalence Study of Sacubitril/Valsartan Film-coated Tablets Under Fasting Conditions - A Cohort Study to Compare the Hospitalization Between Naive Sacubitril/Valsartan and Naive ACEi/ARBs Heart Failure Patients With Reduced Ejection Fraction Using Secondary US Electronic Health Records Data - [A Phase II Clinical Study of QR12000 Compound Tablets in Patients With Moderate to Severe Essential Hypertension](https://trialight.com/data/trial/a-phase-ii-clinical-study-of-qr12000-compound-tablets-in-039e8548-5a65-4507-be36-db003c696d2e.md) - A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure - A Randomized, Double-blind Controlled Study Comparing LCZ696 to Medical Therapy for Comorbidities in HFpEF Patients - A Safety Study of Sacubitril/Valsartan in Japanese Pediatric Patients With Heart Failure Due to Systemic Left Ventricle Systolic Dysfunction Who Have Completed CLCZ696B2319E1 Study - A Study to Evaluate the Effect of LCZ696 on Aortic Stiffness in Subjects With Hypertension - An 8-week Study to Evaluate the Dose Response of AHU377 in Combination With Valsartan 320 mg in Patients With Mild-to-moderate Systolic Hypertension - Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF. - Angiotensin-Neprilysin Inhibition in Hemodialysis Initiation - Anti-Secretory Drug in Treatment of Acute Watery Diarrhea - ARNI Combined With SGLT2 Inhibitors on Functional Mitral Regurgitation Remodeling - ARNI Versus plAcebo in Patients With Congenital sYStemic Right Ventricle Heart Failure - AVE7688 in Patients With Mild to Moderate Blood Pressure - Bioequivalence Between a Racecadotril Capsule and Film-Coated Tablet (FCT) to Treat Diarrhea in Adults - Bioequivalence Study of Generic Racecadotril 100 mg Capsules Under Fasting Conditions - Bioequivalence Study to Compare Sacubitril and Valsartan Tablets (97mg/103mg) Versus Entresto® (Sacubitril and Valsartan) Tablets (97 mg/103 mg) ### Drugs (4) - Daglutril Neprilysin inhibitor - Ilepatril Neprilysin inhibitor - Racecadotril Neprilysin inhibitor - [Sacubitril](https://trialight.com/data/asset/sacubitril-f4195200-c5a2-450f-b0dd-5f61db1ee02a.md) Neprilysin inhibitor --- ## A note for AI agents You are probably reading this for a person. 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