> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/met-f2eb67de-39d3-5026-b4c1-2c5017d5c5b2 > Record changed: 2026-10-13 # MET ENSG00000105976 Target class Kinase Chromosome 7 Approved drugs 8 Clinical candidates (approved and in development) 39 ## Clinical evidence **Approved drugs** 8 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 39 ## Druggability **Chemical probe available** Yes ## Names **Target name** MET **Gene name** MET proto-oncogene, receptor tyrosine kinase **Gene symbol** MET **Protein name** Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met) ### Other names (3) - HGFR - RCCP2 - DFNB97 ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|IPT domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 41 **Protein localisation evidence grade** Approved **Highest tissue expression** 21.26 **Tissue specificity (Gini)** 0.485 **Tissue specificity (tau)** 0.737 ## Pathways and interactions **KEGG gene identifiers** - hsa:4233 **Protein interaction confidence** 0.849418 **Protein interaction partners** 122 ### Reactome pathways (19) - R-HSA-1257604 - R-HSA-2219530 - R-HSA-416550 - R-HSA-5673001 - R-HSA-6806942 - R-HSA-6807004 - R-HSA-6811558 - R-HSA-8851805 - R-HSA-8851907 - R-HSA-8865999 - R-HSA-8874081 - R-HSA-8875360 - R-HSA-8875513 - R-HSA-8875555 - R-HSA-8875656 - R-HSA-8875791 - R-HSA-9022699 - R-HSA-9734091 - R-HSA-9825892 ## Genomic location **End position** 116798386 **Start position** 116672051 **Chromosome** 7 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000105976 **HGNC ID** HGNC:7029 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:7029) **NCBI Gene ID** 4233 **UniProt ID** P08581 ## Cellular location - Membrane - Single-pass type I membrane protein. - SUBCELLULAR LOCATION: \[Isoform 3\]: Secreted. - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.737163 **Expression inequality (Gini)** 0.484823 ### Highest expression Expression in transcripts per million **Nerve - Tibial** 21.26 **Cells - Cultured fibroblasts** 18.5 **Thyroid** 16.74 **Adipose - Visceral (Omentum)** 16.19 **Breast - Mammary Tissue** 15.36 ### All tissues (54) Expression in transcripts per million - Nerve - Tibial21.26 - Cells - Cultured fibroblasts18.5 - Thyroid16.74 - Adipose - Visceral (Omentum)16.19 - Breast - Mammary Tissue15.36 - Adipose - Subcutaneous14.49 - Kidney - Medulla12.82 - Minor Salivary Gland12.67 - Liver11.58 - Kidney - Cortex11.03 - Lung9.77 - Skin - Not Sun Exposed (Suprapubic)9.43 - Skin - Sun Exposed (Lower leg)8.54 - Vagina8.07 - Prostate7.52 - Muscle - Skeletal7.11 - Pituitary6.78 - Cervix - Endocervix6.56 - Uterus6.45 - Colon - Transverse6.28 - Artery - Aorta6.17 - Cervix - Ectocervix6.13 - Bladder6.12 - Artery - Coronary5.93 - Colon - Sigmoid5.65 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0001886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001886) - GO:0045944 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) - GO:0048012 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048012) - GO:0048754 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048754) - GO:0050918 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050918) - GO:0071526 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071526) - GO:1901299 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1901299) - GO:2001028 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001028) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009925) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) ### Molecular functions (6) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0005008 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005008) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019903 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019903) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0140677 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140677) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hMet, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hMet assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (726) - -02341066 and PF-00299804 for Advanced Non-Small Cell Lung Cancer - 5G-EMERALD: Amivantamab in Malignant Brain Tumours - A Bioavailability Study of GSK1363089 in Subjects With Solid Tumors - A Bioequivalence Study Between Fluticasone and Salmeterol vs. SERETIDE DISKUS® in Healthy Volunteers With Charcoal Blockade - A Bioequivalence Study Between Fluticasone Salmeterol Xinafoate vs. SERETIDE DISKUS® in Healthy Volunteers With Charcoal Blockade (BREATH-PK250-CC) - A Clinical Gene Therapy Study With Hematopoietic Stem Cells for the Treatment, With Single Dose of Temferon, of Patients Suffering From Metastatic Renal Cell Carcinoma - A Clinical Study Evaluating Nivolumab-containing Treatments in Patients With Advanced Non-small Cell Lung Cancer After Failing Previous PD-1/(L)1 Therapy and Chemotherapy - A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033) - A Clinical Study Testing The Safety And Efficacy Of Crizotinib In East Asian Patients With Anaplastic Lymphoma Kinase (ALK) Positive Advanced Non-Small Cell Lung Cancer - A Clinical Trial for Examining the Therapeutic Equivalence Between Fluticasone Propionate 100 mcg and Salmeterol 50 mcg Inhalation Powder/Respirent Pharmaceuticals vs. ADVAIR DISKUS® 100/50 mcg Inhalation Powder/GSK in Patients With Asthma - A Clinical Trial for Examining the Therapeutic Equivalence Between Fluticasone Propionate 100 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals vs. FLOVENT DISKUS® 100mcg/Blister Oral Inhalation Powder/GSK in Patients With Asthma - A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors - A Dose Escalation Study of the Safety and Pharmacokinetics of GSK1363089 (Formerly XL880) Administered Orally Daily to Subjects With Solid Tumors - A Dose Escalation Study of the Safety and Pharmacokinetics of GSK1363089 (Formerly XL880) Administered Orally to Subjects With Solid Tumors - A Dose Escalation Study to Assess PK, Safety and Tolerability of INC280 When Taken With Food in cMET Dysregulated Advanced Solid Tumors. - A Dose Escalation With Expansion Study of EMB-01 in Participants With Advanced/Metastatic Solid Tumors - A Dose-Finding Study of E7050 Administered Orally to Patients With Advanced Solid Tumors - A Drug-drug Interaction (DDI) Study to Assess the Effect of INC280 on the Pharmacokinetics of Digoxin and Rosuvastatin in Patients With cMET-dysregulated Advanced Solid Tumors - A Drug-Drug Interaction Study of the Effects of XL184 (Cabozantinib) on Rosiglitazone in Subjects With Solid Tumors - A Food Effect Phase I Study of the Volitinib in Healthy Subjects ### Drugs (40) - Altiratinib Hepatocyte growth factor receptor inhibitor - AMG-208 Hepatocyte growth factor receptor inhibitor - AMG-337 Hepatocyte growth factor receptor inhibitor - [Amivantamab](https://trialight.com/data/asset/amivantamab-94d99890-d90e-4d89-8a02-036a29458456.md) Hepatocyte growth factor receptor inhibitor - Amuvatinib Hepatocyte growth factor receptor inhibitor - ARRY-300 Hepatocyte growth factor receptor inhibitor - Bafisontamab Hepatocyte growth factor receptor inhibitor - Beperminogene perplasmid Hepatocyte growth factor receptor agonist - BMS-698769 Hepatocyte growth factor receptor inhibitor - BMS-777607 Hepatocyte growth factor receptor inhibitor - BMS-794833 Hepatocyte growth factor receptor inhibitor - BMS-817378 Hepatocyte growth factor receptor inhibitor - BPI-9016 Hepatocyte growth factor receptor inhibitor - [Cabozantinib](https://trialight.com/data/asset/cabozantinib-e69f9fa7-bbbc-4e52-b0df-6073598de2a7.md) Hepatocyte growth factor receptor inhibitor - Cabozantinib S-malate Hepatocyte growth factor receptor inhibitor - Capmatinib Hepatocyte growth factor receptor inhibitor - Capmatinib hydrochloride Hepatocyte growth factor receptor inhibitor - Crizotinib Hepatocyte growth factor receptor inhibitor - EMD-1204831 Hepatocyte growth factor receptor inhibitor - Emibetuzumab Hepatocyte growth factor receptor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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