> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/mcl1-952bccac-f5b2-5c83-9d7e-c372c43eef35
> Record changed: 2026-11-04

# MCL1

ENSG00000143384

Target class

Other cytosolic protein

Chromosome

1

Approved drugs

0

Clinical candidates (approved and in development)

1

## Clinical evidence

**Approved drugs**

0

**Clinical candidates (approved and in development)**

1

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

MCL1

**Gene name**

MCL1 apoptosis regulator, BCL2 family member

**Gene symbol**

MCL1

**Protein name**

Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)

### Other names (2)

- BCL2L3
- Mcl-1

## Classification

**Gene biotype**

Protein coding

**Gene family**

BCL2 family

**Target class**

Other cytosolic protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Enhanced

**Highest tissue expression**

474.74

**Tissue specificity (Gini)**

0.337

**Tissue specificity (tau)**

0.641

## Pathways and interactions

**KEGG gene identifiers**

- hsa:4170

**Protein interaction confidence**

0.832684

**Protein interaction partners**

76

### Reactome pathways (2)

- R-HSA-6785807
- R-HSA-9725370

## Genomic location

**End position**

150579738

**Start position**

150560895

**Chromosome**

1

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000143384

**HGNC ID**

HGNC:6943

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6943)

**NCBI Gene ID**

4170

**UniProt ID**

Q07820

## Cellular location

- Membrane
- Single-pass membrane protein . Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
- Mitochondria

## Tissue expression

**Tissue specificity (tau)**

0.640645

**Expression inequality (Gini)**

0.337079

### Highest expression

Expression in transcripts per million

**Lung**

474.74

**Artery - Aorta**

384.63

**Whole Blood**

376.55

**Adipose - Visceral (Omentum)**

364.87

**Cells - Cultured fibroblasts**

313.95

### All tissues (54)

Expression in transcripts per million

- Lung474.74
- Artery - Aorta384.63
- Whole Blood376.55
- Adipose - Visceral (Omentum)364.87
- Cells - Cultured fibroblasts313.95
- Artery - Coronary309.89
- Skin - Not Sun Exposed (Suprapubic)298.59
- Nerve - Tibial293.96
- Spleen283.05
- Skin - Sun Exposed (Lower leg)272.28
- Artery - Tibial258.96
- Esophagus - Mucosa250.97
- Cells - EBV-transformed lymphocytes246.51
- Breast - Mammary Tissue241.31
- Vagina241.31
- Fallopian Tube237.9
- Esophagus - Gastroesophageal Junction227.8
- Adipose - Subcutaneous226.95
- Esophagus - Muscularis224.06
- Thyroid218.58
- Uterus211.45
- Colon - Sigmoid206.08
- Small Intestine - Terminal Ileum200.19
- Minor Salivary Gland197.91
- Bladder195.03

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (9)

- GO:0006974  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974)
- GO:0010507  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010507)
- GO:0034097  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034097)
- GO:0043065  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043065)
- GO:0043066  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066)
- GO:0097192  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097192)
- GO:1903378  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903378)
- GO:2000811  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000811)
- GO:2001240  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001240)

### Cellular components (7)

- GO:0005634  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005739  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739)
- GO:0005741  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005741)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)
- GO:0097136  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097136)

### Molecular functions (4)

- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008320  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008320)
- GO:0046982  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982)
- GO:0051434  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051434)

## Related records

### Trials (723)

- 8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia
- A Clinical Trial to Learn About the Study Medicine Called Maplirpacept (PF-07901801), Alone and When Used in Combination With Other Medicines to Treat Participants With Advanced Hematological Malignancies, Including Lymphoma, Leukemia and Multiple Myeloma
- A Dose-Finding and Efficacy Study of Venetoclax, CC-486, and Obinutuzumab in Follicular Lymphoma
- A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)
- A Multi-Site Break Through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib
- A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax
- A Multicenter Trial Evaluating Efficacy and Safety of A Reduced Venetoclax Exposure To Seven Days Versus Standard Continuous Venetoclax Exposure Combined With Azacitidine in Treatment Naïve Subjects With Acute Myeloid Leukemia Who Are Ineligible for Intensive Induction
- a New Treatment of Newly Diagnosed IDH1 Mutation Acute Myeloid Leukemia
- A Pharmacokinetic Study to Access How the Body Absorbs and Removes ABT-199 in Adults With Non-Hodgkin's Lymphoma
- A Phase 1 Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma
- A Phase 1 Study of AOH1996 in Patients With Relapsed/Refractory Acute Myeloid Leukemia
- A Phase 1 Study With LYT-200 in Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML), or With Relapsed/Refractory, High-risk Myelodysplastic Syndrome (MDS)
- [A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)](https://trialight.com/data/trial/a-phase-1-2-study-of-enzomenib-dsp-5336-in-patients-with-0e6145c8-1f49-44ed-a3c6-01e969666e64.md)
- A Phase 1b Master Trial to Investigate CPX-351 in Subjects With Previously Untreated Acute Myeloid Leukemia
- A Phase 1b Study Evaluating the Safety and Tolerability of ABT-199 in Combination With Rituximab in Subjects With Relapsed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
- A Phase 1b Study of CLN-049 in Combination With Azacitidine and Venetoclax in AML Patients
- A Phase 1b-2 Trial to Assess Venetoclax and Navitoclax Consolidation and Post-transplant Maintenance in High-risk Patients With T-ALL
- A Phase 1B/2A Trial of NADUNOLIMAB in Combination With Azacitidine (With/Without Venetoclax) in Patients With Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML)
- A Phase 2 Open-Label Study of the Efficacy and Safety of ABT-199 (GDC-0199) in Chronic Lymphocytic Leukemia (CLL) Subjects With Relapse or Refractory to B-Cell Receptor Signaling Pathway Inhibitor Therapy
- A Phase 2 Study of ABT-199 in Subjects With Acute Myelogenous Leukemia (AML)

### Drugs (4)

- AZD-5991
- Obatoclax Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitor
- Obatoclax mesylate Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitor
- [Venetoclax](https://trialight.com/data/asset/venetoclax-8c5219f4-7631-4292-b4f0-2c601d914e9f.md)

---

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