> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/mc2r-ab7dde84-90d2-5da6-b098-b08b71234db9 > Record changed: 2026-10-13 # MC2R ENSG00000185231 Target class GPCR Chromosome 18 Approved drugs 4 Clinical candidates (approved and in development) 4 ## Clinical evidence **Approved drugs** 4 **Clinical candidates (approved and in development)** 4 ## Druggability **Chemical probe available** No ## Names **Other names** - ACTHR **Target name** MC2R **Gene name** Melanocortin 2 receptor **Gene symbol** MC2R **Protein name** Adrenocorticotropic hormone receptor (ACTH receptor) (ACTH-R) (Adrenocorticotropin receptor) (Melanocortin receptor 2) (MC2-R) ## Classification **Gene biotype** Protein coding **Gene family** Melanocortin receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 2 **Highest tissue expression** 44.59 **Tissue specificity (Gini)** 0.98 **Tissue specificity (tau)** 0.999 ## Pathways and interactions **KEGG gene identifiers** - hsa:4158 **Protein interaction confidence** 0.878417 **Protein interaction partners** 24 ### Reactome pathways (3) - R-HSA-375276 - R-HSA-418555 - R-HSA-5579031 ## Genomic location **End position** 13915707 **Start position** 13882043 **Chromosome** 18 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000185231 **HGNC ID** HGNC:6930 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6930) **NCBI Gene ID** 4158 **UniProt ID** Q01718 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (3) - PubMed 19535343 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19535343/) - PubMed 21862608 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21862608/) - PubMed 36588120 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/36588120/) ## Tissue expression **Tissue specificity (tau)** 0.999281 **Expression inequality (Gini)** 0.979657 ### Highest expression Expression in transcripts per million **Adrenal Gland** 44.59 **Pituitary** 1.15 **Testis** 0.53 **Prostate** 0.01 **Kidney - Medulla** 0.01 ### All tissues (54) Expression in transcripts per million - Adrenal Gland44.59 - Pituitary1.15 - Testis0.53 - Prostate0.01 - Kidney - Medulla0.01 - Esophagus - Mucosa0 - Bladder0 - Thyroid0 - Brain - Hypothalamus0 - Skin - Sun Exposed (Lower leg)0 - Skin - Not Sun Exposed (Suprapubic)0 - Small Intestine - Terminal Ileum0 - Minor Salivary Gland0 - Artery - Coronary0 - Cervix - Ectocervix0 - Esophagus - Gastroesophageal Junction0 - Heart - Left Ventricle0 - Kidney - Cortex0 - Liver0 - Cells - EBV-transformed lymphocytes0 - Artery - Aorta0 - Breast - Mammary Tissue0 - Pancreas0 - Esophagus - Muscularis0 - Brain - Nucleus accumbens (basal ganglia)0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187) - GO:0007189 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007189) - GO:0031948 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031948) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (3) - GO:0004977 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004977) - GO:0004978 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004978) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Off-target safety - regulation of transcription factor activity ### Studies - cell-based: ATG\_GPCR\_MC2R\_TRANS is one of 35 assay component(s) measured or calculated from the ATG\_GPCR assay. It is designed to make measurements of mRNA induction, a form of inducible reporter, as detected with fluorescence intensity signals by reverse transcription polymerase chain reaction (RT-PCR) and Capillary electrophoresis technology. ### Biological samples - HepG2, cell line Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (147) - (ACTH) for the Treatment of Sarcoid Uveitis - A Clinical Study on the Treatment of Wilson Disease With ATP7B mRNA/LNP (DSL101) - A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis - A Dose-response Study of Tranexamic Acid in Total Hip Arthroplasty - A Novel Approach to Infantile Spasms - A Phase 1 Study to Assess an Escalating Dose, Multi-prime Vaccination Schedule of R21/Matrix-M™ - A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer - A Phase I Study in Healthy Volunteers to Assess the Effect of Cytochrome3A4 (CYP3A4) Inhibitors (Diltiazem and Itraconazole) on the Pharmacokinetics (PK) of AZD3293 and the Effects of AZD3293 on the Pharmacokinetics of Midazolam, a Cytochrome 3A4 and Cytochrome 3A5 (CYP3A4/CYP3A5) Substrate - A Phase I/II Study of BMN053 in Subjects With Duchenne Muscular Dystrophy (DMD) - A Phase II Clinical Trial of the Safety and Efficacy of SAL056 at Different Doses and Dosing Regimens - A Study of Acthar Gel Alone or With Tacrolimus to Reduce Proteinuria in Fibrillary Glomerulopathy Patients - A Study of Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of KAN-101 in Celiac Disease (ACeD-it) - A Study to Evaluate the Safety and Efficacy of Ustekinumab in Patients With Moderately to Severely Active Crohn's Disease Who Have Failed or Are Intolerant to Tumor Necrosis Factor (TNF) Antagonist Therapy (UNITI-1) - A Study to Evaluate the Safety and Efficacy of Ustekinumab Induction Therapy in Patients With Moderately to Severely Active Crohn's Disease (UNITI-2) - A Study to Explore the Safety and Tolerability of Acthar in Patients With Amyotrophic Lateral Sclerosis - A Trial of Neuroprotection With ACTH in Acute Optic Neuritis - A Two-Arm Study Evaluation H.P. Acthar Injection Gel in Treatment of Chronic Migraines - ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study) - ACTH for Fatigue in Multiple Sclerosis Patients - ACTH Gel Therapy in Rheumatoid Arthritis ### Drugs (4) - Corticotropin Melanocortin receptor 2 agonist - Corticotropin zinc hydroxide Melanocortin receptor 2 agonist - [Cosyntropin](https://trialight.com/data/asset/cosyntropin-3b86edbf-74b8-49b8-bb10-5556533ff123.md) Melanocortin receptor 2 agonist - Seractide acetate Melanocortin receptor 2 agonist --- ## A note for AI agents You are probably reading this for a person. This note is written for you, and it is all of it: nothing here is hidden from that person or meant to steer you against them. - Cite this page with its date. Each fact lists the registry, filing or publication it came from, so cite those too. - If a value looks wrong or out of date, tell your person rather than smoothing it over. 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