> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/mapk11-0aa9f796-2f82-5dce-b5ba-24ce4a7c5897 > Record changed: 2026-10-13 # MAPK11 ENSG00000185386 Target class Kinase Chromosome 22 Approved drugs 1 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** Yes ## Names **Target name** MAPK11 **Gene name** Mitogen-activated protein kinase 11 **Gene symbol** MAPK11 **Previous gene symbols** - PRKM11 **Protein name** Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) ### Other names (3) - p38-2 - p38Beta - SAPK2 ## Classification **Gene biotype** Protein coding **Gene family** Mitogen-activated protein kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Approved **Highest tissue expression** 105.53 **Tissue specificity (Gini)** 0.404 **Tissue specificity (tau)** 0.752 ## Pathways and interactions **KEGG gene identifiers** - hsa:5600 **Protein interaction confidence** 0.877707 **Protein interaction partners** 99 ### Reactome pathways (13) - R-HSA-168638 - R-HSA-171007 - R-HSA-198753 - R-HSA-2151209 - R-HSA-2559580 - R-HSA-4420097 - R-HSA-450302 - R-HSA-450341 - R-HSA-450604 - R-HSA-525793 - R-HSA-5668599 - R-HSA-6804756 - R-HSA-69601 ## Genomic location **End position** 50270767 **Start position** 50263713 **Chromosome** 22 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000185386 **HGNC ID** HGNC:6873 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6873) **NCBI Gene ID** 5600 **UniProt ID** Q15759 ## Cellular location - Cytoplasm . Nucleus . - Cytosol ## Tissue expression **Tissue specificity (tau)** 0.751792 **Expression inequality (Gini)** 0.40435 ### Highest expression Expression in transcripts per million **Brain - Cerebellum** 105.53 **Brain - Cerebellar Hemisphere** 93.82 **Brain - Cortex** 82.2 **Brain - Frontal Cortex (BA9)** 71.45 **Brain - Anterior cingulate cortex (BA24)** 55.5 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellum105.53 - Brain - Cerebellar Hemisphere93.82 - Brain - Cortex82.2 - Brain - Frontal Cortex (BA9)71.45 - Brain - Anterior cingulate cortex (BA24)55.5 - Pituitary52.59 - Adipose - Visceral (Omentum)43.84 - Uterus43.55 - Breast - Mammary Tissue42.22 - Adipose - Subcutaneous41.24 - Brain - Caudate (basal ganglia)41.02 - Cervix - Endocervix40.6 - Brain - Nucleus accumbens (basal ganglia)39.27 - Cervix - Ectocervix38.39 - Fallopian Tube36.36 - Brain - Putamen (basal ganglia)35.01 - Prostate34.94 - Lung32.41 - Nerve - Tibial31.98 - Brain - Amygdala31.73 - Spleen26.49 - Kidney - Medulla26.25 - Ovary25.57 - Brain - Hippocampus25.35 - Brain - Hypothalamus25.28 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (11) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0031098 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031098) - GO:0032735 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032735) - GO:0038066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038066) - GO:0045648 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045648) - GO:0051149 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051149) - GO:0051403 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051403) - GO:0071347 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071347) - GO:0071493 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071493) - GO:0090398 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090398) - GO:0098586 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098586) ### Cellular components (2) - GO:0005654 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005654) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) ### Molecular functions (4) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0004707 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004707) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0106310 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106310) ## Off-target safety - regulation of catalytic activity ### Studies - biochemical: NVS\_ENZ\_hMAPK11, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hMAPK11 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (416) - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST - \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib - \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial - \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma - \[68 Ga\]-DOTANOC PET/CT in GEP-NETs - \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas - \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation - 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET) - 18F-DCFBC PET/CT in Prostate Cancer - 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer - 5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer - 68Ga-NODAGA-RGD PET/ CT for Tumoral Neoangiogenesis - 68Ga-NY104 PET/CT Guided Radiation Therapy in CcRCC. - 68Ga-NYM096/177Lu-NYM096 in Metastatic ccRCC - 68Ga-PSMA PET/CT in Prostate Cancer - 68Ga-PSMA PET/CT in Prostate Cancer - 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Intermediate Risk Prostate Cancer Imaging - 68Ga-RM2 Compared to 68Ga-PSMA-617 PET/CT for Prostate Cancer Imaging According to Various Metastatic Risks - 89Zr-TLX250 for PET/CT Imaging of ccRCC - ZIRCON-CP Study ### Drugs (3) - Losmapimod MAP kinase p38 beta inhibitor - [Regorafenib](https://trialight.com/data/asset/regorafenib-333c1c36-b89a-41d5-b39e-bcec7346fe94.md) MAP kinase p38 beta inhibitor - RWJ-67657 MAP kinase p38 beta inhibitor --- ## A note for AI agents You are probably reading this for a person. 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