> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/map2k1-4497ab8d-b990-5d3e-8e15-5320bf37cb8d > Record changed: 2026-10-13 # MAP2K1 ENSG00000169032 Target class Kinase Chromosome 15 Approved drugs 7 Clinical candidates (approved and in development) 20 ## Clinical evidence **Approved drugs** 7 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 20 ## Druggability **Chemical probe available** Yes ## Names **Target name** MAP2K1 **Gene name** Mitogen-activated protein kinase kinase 1 **Gene symbol** MAP2K1 **Previous gene symbols** - PRKMK1 **Protein name** Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) ### Other names (3) - MEK1 - MAPKK1 - MKK1 ## Classification **Gene biotype** Protein coding **Gene family** Mitogen-activated protein kinase kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 99.13 **Tissue specificity (Gini)** 0.237 **Tissue specificity (tau)** 0.634 ## Pathways and interactions **KEGG gene identifiers** - hsa:5604 **Protein interaction confidence** 0.8715 **Protein interaction partners** 80 ### Reactome pathways (15) - R-HSA-110056 - R-HSA-170968 - R-HSA-445144 - R-HSA-5210891 - R-HSA-5673000 - R-HSA-5674135 - R-HSA-5674499 - R-HSA-5684264 - R-HSA-6802946 - R-HSA-6802948 - R-HSA-6802952 - R-HSA-6802955 - R-HSA-9649948 - R-HSA-9652169 - R-HSA-9656223 ## Genomic location **End position** 66491656 **Start position** 66386825 **Chromosome** 15 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000169032 **HGNC ID** HGNC:6840 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6840) **NCBI Gene ID** 5604 **UniProt ID** Q02750 ## Cellular location - Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Cytoplasm . Nucleus . Membrane - Peripheral membrane protein . Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (PubMed:14737111). Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742). . - Basal body - Cytosol - Plasma membrane ### Publication evidence (3) - PubMed 14737111 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/14737111/) - PubMed 10409742 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10409742/) - PubMed 17101779 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/17101779/) ## Tissue expression **Tissue specificity (tau)** 0.634429 **Expression inequality (Gini)** 0.237038 ### Highest expression Expression in transcripts per million **Cells - EBV-transformed lymphocytes** 99.13 **Brain - Cerebellar Hemisphere** 89.34 **Brain - Frontal Cortex (BA9)** 87.08 **Brain - Nucleus accumbens (basal ganglia)** 71.7 **Brain - Anterior cingulate cortex (BA24)** 55.9 ### All tissues (54) Expression in transcripts per million - Cells - EBV-transformed lymphocytes99.13 - Brain - Cerebellar Hemisphere89.34 - Brain - Frontal Cortex (BA9)87.08 - Brain - Nucleus accumbens (basal ganglia)71.7 - Brain - Anterior cingulate cortex (BA24)55.9 - Adipose - Subcutaneous53.17 - Brain - Cerebellum51.77 - Artery - Tibial51.39 - Artery - Aorta51.22 - Cells - Cultured fibroblasts47.69 - Esophagus - Mucosa44.26 - Brain - Caudate (basal ganglia)43.52 - Lung43.43 - Artery - Coronary42.42 - Brain - Hippocampus41.51 - Brain - Cortex41.44 - Nerve - Tibial41.3 - Muscle - Skeletal40.9 - Cervix - Ectocervix40.29 - Vagina39.98 - Adipose - Visceral (Omentum)39.35 - Uterus38.93 - Brain - Hypothalamus37.87 - Cervix - Endocervix36.83 - Brain - Amygdala36.63 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (12) - GO:0006935 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006935) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) - GO:0032872 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032872) - GO:0045893 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045893) - GO:0070371 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070371) - GO:0070374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070374) - GO:0071902 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071902) - GO:0090170 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090170) - GO:0090398 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090398) - GO:2000641 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000641) ### Cellular components (12) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005769 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005769) - GO:0005770 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005770) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0036064 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036064) ### Molecular functions (9) - GO:0004672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0004708 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004708) - GO:0004712 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004712) - GO:0005078 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005078) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030295 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030295) - GO:0043539 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043539) - GO:0097110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097110) ## Related records ### Trials (1,104) - "Cocktail" Therapy for Hepatitis B Related Hepatocellular Carcinoma - "Dabrafenib and Trametinib in Circulating Free DNA BRAFV600 Mutated Metastatic Melanoma Patients: a Prospective Phase II, Open Label, Multicentre Study - (Bioliquid TAILOR Study - BIOTAILOR)" - (Neo)Adjuvant BRAF/MEK Inhibition in pN1c Melanoma - 24VA021; VATCH Trametinib for Ras/MAPK Pathway VAs - 5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours - 601 Versus Ranibizumab in Patients With Branch Retinal Vein Occlusion (BRVO) - 601 Versus Ranibizumab in Patients With Central Retinal Vein Occlusion (CRVO) - A 12-Day Randomized, Blinded, Vehicle and Active Comparator-Controlled Study to Determine the Efficacy and Safety of Six Concentrations of Topical E6201 Gel in Subjects With Psoriasis Vulgaris - A Bioequivalence Study Comparing A Fixed Dose Combination Formulation Of Myrin P Forte That Contains Rifampicin, Isoniazid, Ethambutol And Pyrazinamide Per Tablet To An Equivalent Dose Of Single Drug Reference Preparations Of Similar Combination Following Oral Administration In Healthy Adults - A Clinical Study Evaluating the Safety and Efficacy of BCMA-GPRC5D CAR-T in Patients With Relapsed/Refractory Multiple Myeloma Who Have Received Three or More Lines of Treatment - A Clinical Study Evaluating the Safety, Tolerability, and Efficacy of MT1013 in Hemodialysis Subjects With Secondary Hyperparathyroidism - A Clinical Study Evaluating the Safety, Tolerability, and Initial Efficacy of Single Intravenous Infusion of JWK007 in Patients With Duchenne Muscular Dystrophy (DMD) - A Clinical Study of Cobimetinib Administered in Combination With Niraparib, With or Without Atezolizumab to Patients With Advanced Platinum-sensitive Ovarian Cancer - A Clinical Study, to Evaluate the Safety and Tolerability of Intradermal IMM-101 in Adult Melanoma Cancer Patients - A Clinical Trial of Patients With Melanoma - A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma - A Clinical Trial to Evaluate a Melanoma Helper Peptide Vaccine Plus Dabrafenib and Trametinib - A Cohort Study on the Safety and Efficacy of XH-02 in Treating Hypoparathyroidism - A Combination Product of Sumatriptan and Naproxen Sodium Versus Single-entity Oral Triptans: An Analysis of Real World Data - A Combination Therapy Study of MK-2206 and AZD6244 in Participants With Advanced Solid Tumors (MK-2206-010) ### Drugs (20) - AS-703988 Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - Avutometinib Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - AZD-8330 Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - Balamapimod Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - [Binimetinib](https://trialight.com/data/asset/binimetinib-f5914744-65e2-4d8c-8482-9f51a406315e.md) Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - CI-1040 Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - Cobimetinib Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - Cobimetinib fumarate Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - E-6201 Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - Mirdametinib Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - Pimasertib Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - Refametinib Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - RG-7167 Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor - RO-4987655 Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - Selumetinib Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - Selumetinib sulfate Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor - TAK-733 Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - [Trametinib](https://trialight.com/data/asset/trametinib-97f99b88-da7f-40fc-a4ab-00520da4e98c.md) Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor - Trametinib dimethyl sulfoxide Dual specificity mitogen-activated protein kinase kinase 1 inhibitor - WX-554 Dual specificity mitogen-activated protein kinase kinase 1 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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