> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/maob-ac8a92ad-9e33-53f0-b021-7f1e9d228461 > Record changed: 2026-10-13 # MAOB ENSG00000069535 Target class Enzyme Chromosome X Approved drugs 13 Clinical candidates (approved and in development) 15 ## Clinical evidence **Approved drugs** 13 **Clinical candidates (approved and in development)** 15 ## Druggability **Chemical probe available** Yes ## Names **Target name** MAOB **Gene name** Monoamine oxidase B **Gene symbol** MAOB **Protein name** Amine oxidase \[flavin-containing\] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) ## Classification **Gene biotype** Protein coding **Gene family** Flavoproteins **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Highest tissue expression** 240.44 **Tissue specificity (Gini)** 0.421 **Tissue specificity (tau)** 0.76 ## Pathways and interactions **KEGG gene identifiers** - hsa:4129 **Reactome pathways** - R-HSA-141333 **Protein interaction confidence** 0.899518 **Protein interaction partners** 56 ## Genomic location **End position** 43882559 **Start position** 43766400 **Chromosome** X **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000069535 **HGNC ID** HGNC:6834 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6834) **NCBI Gene ID** 4129 **UniProt ID** P27338 ## Cellular location - Mitochondrion outer membrane - Single-pass type IV membrane protein - Cytoplasmic side. ## Tissue expression **Tissue specificity (tau)** 0.759579 **Expression inequality (Gini)** 0.420965 ### Highest expression Expression in transcripts per million **Ovary** 240.44 **Uterus** 239.79 **Fallopian Tube** 186.17 **Artery - Tibial** 135.14 **Artery - Aorta** 126.28 ### All tissues (54) Expression in transcripts per million - Ovary240.44 - Uterus239.79 - Fallopian Tube186.17 - Artery - Tibial135.14 - Artery - Aorta126.28 - Brain - Hypothalamus119.54 - Artery - Coronary103.51 - Liver99.71 - Esophagus - Gastroesophageal Junction98.37 - Brain - Nucleus accumbens (basal ganglia)95.86 - Esophagus - Muscularis90.28 - Brain - Caudate (basal ganglia)82.89 - Colon - Sigmoid77.51 - Brain - Frontal Cortex (BA9)73.14 - Adipose - Subcutaneous72.17 - Brain - Spinal cord (cervical c-1)70.48 - Breast - Mammary Tissue70.22 - Brain - Substantia nigra67.24 - Adrenal Gland64.1 - Small Intestine - Terminal Ileum62.84 - Brain - Anterior cingulate cortex (BA24)59.29 - Cervix - Endocervix59.05 - Prostate58.89 - Lung58.38 - Brain - Cortex57.34 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0021762 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0021762) - GO:0042420 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042420) ### Cellular components (3) - GO:0005739 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005739) - GO:0005740 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005740) - GO:0005741 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005741) ### Molecular functions (4) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0008131 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008131) - GO:0009055 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009055) - GO:0097621 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097621) ## On-target safety - hallucinations ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - diarrhoea ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - GI PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - dyskinesia ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - dizziness ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Hypertension ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Related records ### Trials (144) - 18-month Study of Long-term Efficacy & Safety of Safinamide as add-on Therapy in Patients With Mid-late Stage PD - A Double Blind Placebo Controlled Trial Evaluating Rasagiline Effects on Cognition in Parkinson's Disease Patients With Mild Cognitive Impairment Receiving Dopaminergic Therapy - A Long-term, Phase 3 Study of TVP-1012 (1 mg) in Levodopa Treated Parkinson's Disease Participants - A Non-Blinded Study Demonstrating the Effectiveness and Safety of Azilect Alone or in Combination Therapy in Parkinson's Disease - A Phase 2/3 Study of TVP-1012 at 0.5 mg or 1 mg in Levodopa Treated Parkinson's Disease Participants - A Phase 3 Study of TVP-1012 (1 mg) in Early Parkinson's Disease Patients - A Phase 3 Study With P2B001 in Subjects With Early Parkinson's - A Phase 3, Long-term, Extension Study of TVP-1012 (1 mg) in Early Parkinson's Disease Participants - A Pilot Study Assessing EmSam in Bipolar Depression - A Placebo- and Active Controlled Study of Preladenant in Subjects With Moderate to Severe Parkinson's Disease (P04938) - A Placebo- and Active-Controlled Study of Preladenant in Early Parkinson's Disease (PD) (P05664) - A Randomized Placebo Controlled Study to Show That Rasagiline May Slow Disease Progression for Parkinson's Disease - A Single and Multiple Dose Study to Assess How the Drug Enters, Moves Through and Exits the Body, Safety and Tolerability of Safinamide in Healthy Adult Chinese Volunteers - A Study Assessing Change in Sense of Smell After Rasagiline Use in Parkinson's Patients - A Study in Healthy People to Test How Combining BI 1467335 and Tyramine Affects Blood Pressure - A Study of Decreased Mental Function Associated With HIV - A Study of RO4602522 in Patients With Alzheimer Disease and in Healthy Volunteers - A Study of Thioctic Acid and Deprenyl in HIV-Infected Patients With Dementia - A Study to Assess the Bioavailability and Adhesion of Selegiline TDS in Healthy Subjects - A Study to Assess the Effect of Hepatic Impairment on Safinamide Pharmacokinetics ### Drugs (19) - Iproniazid Monoamine oxidase inhibitor - Isocarboxazid Monoamine oxidase inhibitor - Mebanazine Monoamine oxidase inhibitor - Nialamide Monoamine oxidase inhibitor - Pargyline Monoamine oxidase inhibitor - Pargyline hydrochloride Monoamine oxidase inhibitor - Phenelzine Monoamine oxidase inhibitor - Phenelzine sulfate Monoamine oxidase inhibitor - Phenoxypropazine Monoamine oxidase inhibitor - Ralfinamide Monoamine oxidase B inhibitor - Rasagiline Monoamine oxidase B inhibitor - Rasagiline mesylate Monoamine oxidase B inhibitor - Rasagiline tartrate Monoamine oxidase B inhibitor - Safinamide Monoamine oxidase B inhibitor - Safinamide mesylate Monoamine oxidase B inhibitor - [Selegiline](https://trialight.com/data/asset/selegiline-75105152-976c-4285-a021-0f60934ae019.md) Monoamine oxidase B inhibitor - Selegiline hydrochloride Monoamine oxidase B inhibitor - Tranylcypromine Monoamine oxidase inhibitor - Tranylcypromine sulfate Monoamine oxidase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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