> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/lyn-11539fac-644a-5156-95c1-0c4a92e18279 > Record changed: 2026-11-04 # LYN ENSG00000254087 Target class Kinase Chromosome 8 Approved drugs 2 Clinical candidates (approved and in development) 9 ## Clinical evidence **Approved drugs** 2 **Clinical candidates (approved and in development)** 9 ## Druggability **Chemical probe available** Yes ## Names **Other names** - JTK8 **Target name** LYN **Gene name** LYN proto-oncogene, Src family tyrosine kinase **Gene symbol** LYN **Protein name** Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) ## Classification **Gene biotype** Protein coding **Gene family** SH2 domain containing|Src family tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 53 **Protein localisation evidence grade** Supported **Highest tissue expression** 128.38 **Tissue specificity (Gini)** 0.637 **Tissue specificity (tau)** 0.925 ## Pathways and interactions **KEGG gene identifiers** - hsa:4067 **Protein interaction confidence** 0.871669 **Protein interaction partners** 130 ### Reactome pathways (37) - R-HSA-114604 - R-HSA-1433557 - R-HSA-1433559 - R-HSA-202733 - R-HSA-2029481 - R-HSA-210990 - R-HSA-2454202 - R-HSA-2682334 - R-HSA-2730905 - R-HSA-2871796 - R-HSA-2871809 - R-HSA-2871837 - R-HSA-389356 - R-HSA-389513 - R-HSA-3928662 - R-HSA-3928663 - R-HSA-3928665 - R-HSA-5621480 - R-HSA-5621575 - R-HSA-5690714 - R-HSA-69231 - R-HSA-75892 - R-HSA-9006335 - R-HSA-9027276 - R-HSA-9027277 And 12 more, listed on the interactive page. ## Genomic location **End position** 56014169 **Start position** 55879825 **Chromosome** 8 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000254087 **HGNC ID** HGNC:6735 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6735) **NCBI Gene ID** 4067 **UniProt ID** P07948 ## Cellular location - Cell membrane. Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Membrane - Lipid-anchor . Note=Accumulates in the nucleus by inhibition of CRM1-mediated nuclear export. Nuclear accumulation is increased by inhibition of its kinase activity. The trafficking from the Golgi apparatus to the plasma membrane occurs in a kinase domain-dependent but kinase activity independent manner and is mediated by exocytic vesicular transport. Detected on plasma membrane lipid rafts. - Golgi apparatus - Plasma membrane - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.925244 **Expression inequality (Gini)** 0.636792 ### Highest expression Expression in transcripts per million **Whole Blood** 128.38 **Cells - EBV-transformed lymphocytes** 119.31 **Spleen** 74.33 **Lung** 33.99 **Small Intestine - Terminal Ileum** 16.57 ### All tissues (54) Expression in transcripts per million - Whole Blood128.38 - Cells - EBV-transformed lymphocytes119.31 - Spleen74.33 - Lung33.99 - Small Intestine - Terminal Ileum16.57 - Minor Salivary Gland14.36 - Thyroid13.68 - Brain - Cerebellar Hemisphere12.34 - Adipose - Visceral (Omentum)10.87 - Adipose - Subcutaneous10.56 - Brain - Cerebellum10.17 - Breast - Mammary Tissue9.98 - Bladder8.29 - Artery - Coronary8.17 - Cervix - Endocervix7.94 - Artery - Aorta7.92 - Vagina7.52 - Fallopian Tube7.31 - Prostate6.7 - Adrenal Gland6.45 - Colon - Transverse6.34 - Esophagus - Mucosa5.91 - Kidney - Medulla5.85 - Pituitary5.77 - Stomach5.77 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (36) - GO:0000077 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000077) - GO:0001932 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001932) - GO:0002223 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002223) - GO:0002244 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002244) - GO:0002513 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002513) - GO:0002768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002768) - GO:0002862 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002862) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0006954 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006954) - GO:0006974 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006974) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007169) - GO:0008285 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008285) - GO:0010976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010976) - GO:0015908 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015908) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0030222 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030222) - GO:0031295 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031295) - GO:0033628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033628) - GO:0034145 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034145) - GO:0034165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034165) - GO:0038043 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038043) - GO:0038095 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038095) - GO:0038096 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038096) - GO:0038159 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038159) And 11 more, listed on the interactive page. ### Cellular components (10) - GO:0005634 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) - GO:0005765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005765) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009898 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009898) - GO:0030666 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030666) - GO:0045121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121) - GO:0048471 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048471) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions (8) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004715 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030546 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030546) - GO:0044325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044325) - GO:0046875 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046875) - GO:0097110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097110) - GO:0140031 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0140031) ## Off-target safety - regulation of catalytic activity ### Studies (2) - biochemical: NVS\_ENZ\_hLynA, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hLynA assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. - biochemical: NVS\_ENZ\_hLynA, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hLynA assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (955) - A Bioequivalence Study of Dasatinib Tablet - A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST - A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma - A Combination of Acalabrutinib With R-CHOP for Patient Diffuse Large B-cell Lymphoma (DLBCL) - A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312) - A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma - A Crossover Study to Evaluate the Bioavailability of Ibrutinib Suspension and Sprinkle Formulations Compared to Capsules in Healthy Adults - A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420. - A Drug Interaction Study Between Bosutinib And Aprepitant In Healthy Volunteers - A Drug Interaction Study to Assess the Effect of Omeprazole on the Pharmacokinetics of Ibrutinib in Healthy Adults - A Long-term Extension Study of PCI-32765 (Ibrutinib) - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Lymphomas - A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Solid Tumors - A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) - A Multicenter Phase 2 Study of Ibrutinib in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) With 17p Deletion - A Multicenter Phase 3, Open-Label Study of Bosutinib Versus Imatinib in Adult Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia - A Pharmacokinetic Study in Healthy Participants to Assess the Pharmacokinetics and Safety of a Supratherapeutic Dose of PCI-32765 (Ibrutinib) Capsule and Solution Formulations Administered With Food - A Phase 1 Safety Study of TG100801 Eye Drops in Healthy Volunteers - A Phase 1 Study of Acalabrutinib in Japanese Adult Patients With Advanced B-cell Malignancies - A Phase 1 Study of MKC-1 in Patients With Refractory Hematologic Malignancies ### Drugs (15) - [Acalabrutinib](https://trialight.com/data/asset/acalabrutinib-17f298f9-e056-45ab-95dc-9a5b0f25c869.md) - Bafetinib Tyrosine-protein kinase Lyn inhibitor - Bosutinib Tyrosine-protein kinase Lyn inhibitor - Dasatinib - Dasatinib anhydrous SRC inhibitor - Dasatinib laurylsulfate SRC inhibitor - ENMD-981693 SRC inhibitor - [Ibrutinib](https://trialight.com/data/asset/ibrutinib-0b3ac4fd-6e98-4847-a711-2f599e8bb93d.md) - Ilorasertib SRC inhibitor - JNJ-26483327 Tyrosine-protein kinase Lyn inhibitor - Pexmetinib - Ponatinib - TG100-801 SRC inhibitor - Tolimidone Tyrosine-protein kinase Lyn positive allosteric modulator - XL-228 SRC inhibitor --- ## A note for AI agents You are probably reading this for a person. 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