> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/ltk-02fcd0de-022c-54f1-b75a-24166359cd2b > Record changed: 2026-11-04 # LTK ENSG00000062524 Target class Kinase Chromosome 15 ## Druggability **Chemical probe available** No ## Names **Other names** - TYK1 **Target name** LTK **Gene name** Leukocyte receptor tyrosine kinase **Gene symbol** LTK **Protein name** Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1) ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 29 **Protein localisation evidence grade** Approved **Highest tissue expression** 28.58 **Tissue specificity (Gini)** 0.606 **Tissue specificity (tau)** 0.935 ## Pathways and interactions **KEGG gene identifiers** - hsa:4058 **Reactome pathways** - R-HSA-9842663 **Protein interaction confidence** 0.89 **Protein interaction partners** 3 ## Genomic location **End position** 41513887 **Start position** 41503634 **Chromosome** 15 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000062524 **HGNC ID** HGNC:6721 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6721) **NCBI Gene ID** 4058 **UniProt ID** P29376 ## Cellular location - Cell membrane - Single-pass type I membrane protein . - Vesicles ### Publication evidence - PubMed 34646012 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/34646012/) ## Tissue expression **Tissue specificity (tau)** 0.934867 **Expression inequality (Gini)** 0.605723 ### Highest expression Expression in transcripts per million **Lung** 28.58 **Spleen** 10 **Small Intestine - Terminal Ileum** 7.58 **Colon - Transverse** 6.41 **Testis** 6.32 ### All tissues (54) Expression in transcripts per million - Lung28.58 - Spleen10 - Small Intestine - Terminal Ileum7.58 - Colon - Transverse6.41 - Testis6.32 - Stomach4.61 - Brain - Cortex4.46 - Brain - Cerebellum4.25 - Kidney - Cortex4.11 - Colon - Sigmoid3.88 - Minor Salivary Gland3.46 - Kidney - Medulla2.8 - Brain - Frontal Cortex (BA9)2.8 - Cervix - Endocervix2.45 - Brain - Cerebellar Hemisphere2.37 - Liver2.07 - Brain - Caudate (basal ganglia)1.82 - Thyroid1.63 - Whole Blood1.48 - Vagina1.46 - Brain - Anterior cingulate cortex (BA24)1.43 - Cervix - Ectocervix1.39 - Adipose - Visceral (Omentum)1.33 - Heart - Atrial Appendage1.32 - Brain - Putamen (basal ganglia)1.26 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (10) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007169) - GO:0008283 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008283) - GO:0010666 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010666) - GO:0010976 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010976) - GO:0038083 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038083) - GO:0043066 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043066) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0071300 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071300) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (5) - GO:0004672 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004672) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030298 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030298) ## On-target safety - heart disease ### Studies - preclinical: Important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Activation of leukocyte receptor tyrosine kinase results in cardiac hypertrophy and cardiomyocyte degeneration ### Biological samples - cardiovascular system PubMed 21283106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/) ## Related records ### Trials (130) - [A Phase 1/2 Study of Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)](https://trialight.com/data/trial/a-phase-1-2-study-of-enzomenib-dsp-5336-in-patients-with-0e6145c8-1f49-44ed-a3c6-01e969666e64.md) - A Phase 2 Study of Gemtuzumab Ozogamicin (GO)-Gilteritinib Combination in Adults With FLT3-ITD and/or FLT3-TKD Relapse/Refractory (R/R) AML - A Phase I/II Study of Gilteritinib and Momelotinib for Patients With Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia - A Retrospective Study of the Efficacy and Safety of Lolatinib in ALK+ NSCLC Patients With Brain or Meningeal Metastasis - A Safety and Efficacy Study of CC-90009 Combinations in Subjects With Acute Myeloid Leukemia - A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Hematologic Malignancies - A Study of ASP2215 (Gilteritinib) by Itself, ASP2215 Combined With Azacitidine or Azacitidine by Itself to Treat Adult Patients Who Have Recently Been Diagnosed With Acute Myeloid Leukemia With a FLT3 Gene Mutation and Who Cannot Receive Standard Chemotherapy - A Study of ASP2215 (Gilteritinib) Combined With Atezolizumab in Patients With Relapsed or Treatment Refractory FMS-like Tyrosine Kinase (FLT3) Mutated Acute Myeloid Leukemia (AML) - A Study of ASP2215 (Gilteritinib), Administered as Maintenance Therapy Following Induction/Consolidation Therapy for Subjects With FMS-like Tyrosine Kinase 3 (FLT3/ITD) Acute Myeloid Leukemia (AML) in First Complete Remission - A Study of ASP2215 in Combination With Erlotinib in Subjects With Epidermal Growth Factor Receptor (EGFR) Activating Mutation-Positive (EGFRm+) Advanced Non-Small-Cell Lung Cancer (NSCLC) Who Have Acquired Resistance to an EGFR Tyrosine Kinase Inhibitor (TKI) - A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia - A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia. - A Study of ASP2215 Versus Salvage Chemotherapy in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-like Tyrosine Kinase (FLT3) Mutation - A Study of ASP2215 Versus Salvage Chemotherapy In Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-like Tyrosine Kinase 3 (FLT3) Mutation - A Study of Gilteritinib (ASP2215) Combined With Chemotherapy in Children, Adolescents and Young Adults With FMS-like Tyrosine Kinase 3 (FLT3)/Internal Tandem Duplication (ITD) Positive Relapsed or Refractory Acute Myeloid Leukemia (AML) - A Study of Gilteritinib in Adults With Advanced ALK-positive Non-small Cell Lung Cancer (NSCLC) - A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML) - A Study of Gilteritinib Versus Midostaurin in Combination With Induction and Consolidation Therapy Followed by One-year Maintenance in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndromes With Excess Blasts-2 With FLT3 Mutations Eligible for Intensive Chemotherapy - A Study of Gilteritinib, Venetoclax and Azacitidine as a Combined Treatment for People Newly Diagnosed With Acute Myeloid Leukemia - A Study of Lorlatinib in Advanced ALK and ROS1 Rearranged Lung Cancer With CNS Metastasis in the Absence of Measurable Extracranial Lesions ### Drugs (2) - [Gilteritinib](https://trialight.com/data/asset/gilteritinib-68aa5aec-0e4f-4efa-bdc8-eba76c8a8a3a.md) - Lorlatinib --- ## A note for AI agents You are probably reading this for a person. 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