> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/lpar1-4312f2d6-d5cd-5aa4-9348-47b5a6e2f879 > Record changed: 2026-11-04 # LPAR1 ENSG00000198121 Target class GPCR Chromosome 9 Approved drugs 0 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** Yes ## Names **Target name** LPAR1 **Gene name** Lysophosphatidic acid receptor 1 **Gene symbol** LPAR1 **Previous gene symbols** - EDG2 **Protein name** Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2) ### Other names (6) - edg-2 - rec.1.3 - vzg-1 - Gpcr26 - Mrec1.3 - LPA1 ## Classification **Gene biotype** Protein coding **Gene family** Lysophosphatidic acid receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 51 **Highest tissue expression** 238.85 **Tissue specificity (Gini)** 0.519 **Tissue specificity (tau)** 0.832 ## Pathways and interactions **KEGG gene identifiers** - hsa:1902 **Protein interaction confidence** 0.903483 **Protein interaction partners** 29 ### Reactome pathways (3) - R-HSA-416476 - R-HSA-418594 - R-HSA-419408 ## Genomic location **End position** 111038863 **Start position** 110871773 **Chromosome** 9 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000198121 **HGNC ID** HGNC:3166 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:3166) **NCBI Gene ID** 1902 **UniProt ID** Q92633 ## Cellular location - Cell surface . Cell membrane - Multi-pass membrane protein . Endosome . Note=Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment. . ### Publication evidence (4) - PubMed 19306925 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19306925/) - PubMed 25025571 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25025571/) - PubMed 26091040 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26091040/) - PubMed 9070858 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9070858/) ## Tissue expression **Tissue specificity (tau)** 0.832272 **Expression inequality (Gini)** 0.518986 ### Highest expression Expression in transcripts per million **Brain - Spinal cord (cervical c-1)** 238.85 **Cells - Cultured fibroblasts** 184.2 **Nerve - Tibial** 150.85 **Brain - Substantia nigra** 139.38 **Brain - Hippocampus** 113.83 ### All tissues (54) Expression in transcripts per million - Brain - Spinal cord (cervical c-1)238.85 - Cells - Cultured fibroblasts184.2 - Nerve - Tibial150.85 - Brain - Substantia nigra139.38 - Brain - Hippocampus113.83 - Brain - Putamen (basal ganglia)112.73 - Brain - Amygdala101.2 - Cervix - Ectocervix92.1 - Artery - Aorta69.13 - Brain - Caudate (basal ganglia)68.13 - Artery - Tibial66.43 - Cervix - Endocervix66.35 - Brain - Hypothalamus61.17 - Vagina49.85 - Adipose - Subcutaneous45.13 - Artery - Coronary43.27 - Bladder43.1 - Brain - Nucleus accumbens (basal ganglia)41.29 - Breast - Mammary Tissue38.48 - Brain - Frontal Cortex (BA9)37.1 - Prostate33.2 - Fallopian Tube32.56 - Colon - Sigmoid31.7 - Esophagus - Gastroesophageal Junction31.58 - Adipose - Visceral (Omentum)31.06 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (6) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007200 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007200) - GO:0007204 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007204) - GO:0043123 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043123) - GO:0060326 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060326) - GO:1902018 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902018) ### Cellular components (4) - GO:0005768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0030139 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030139) ### Molecular functions (4) - GO:0004930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004930) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0035727 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035727) - GO:0070915 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070915) ## Related records ### Trials (125) - A Double-Blinded Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986020 Versus Placebo in Diffuse Cutaneous Systemic Sclerosis (dcSSc) - A Genotype Stratification Study for Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Male Subjects - A Multicenter Trial to Evaluate the Efficacy, Safety and Tolerability of HZN-825 in Subjects With Idiopathic Pulmonary Fibrosis - [A Multicenter Trial to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of HZN-825 in Patients With Diffuse Cutaneous Systemic Sclerosis](https://trialight.com/data/trial/a-multicenter-trial-to-evaluate-the-efficacy-safety-1140ef0a-f792-4396-92eb-e445512ceaa2.md) - A Multidisciplinary, Multimodal Bundled Care Approach to Chronic Pelvic Pain - A Phase 1 Drug-drug Interaction Study in Healthy Volunteers - A Study Investigating the Safety, Tolerability, Drug Levels and Drug Effect of BMS-986278 in Healthy Adult Participants (Part 1) and Japanese Participants (Part 2) - A Study Measuring the Effectiveness, Safety, and Tolerability of BMS-986278 in Participants With Lung Fibrosis - A Study of Experimental Medication BMS-986278 Given to Healthy Participants - A Study of Mianserin in Combination With SSRIs in Depression With Sleep Problems - A Study of the Pharmacokinetic Interaction Between Pirfenidone and BMS-986278 in Healthy Participants - A Study to Assess the Effect of Food on the Drug Levels of Admilparant - A Study to Assess the Effect of Multiple Doses of Itraconazole, Gemfibrozil, or Carbamazepine on BMS-986278 in Healthy Participants - A Study to Assess the Extent of Drug Interaction Between BMS-986278 and Nintedanib, the Relative Bioavailability of BMS-986278 in Tablet and the Effect That Food Has on BMS-986278 in Tablet Formulations in Healthy Participants - A Study to Assess the Levels in Blood Plasma of BMS-986278 in Healthy Participants Following Administration of Tablets, With or Without Food, and in the Presence of an Antacid (Esomeprazole) - A Study to Evaluate BMS-986278 in Participants With Normal Renal Function, Severe Renal Impairment, or End-Stage Renal Disease on Intermittent Hemodialysis - A Study to Evaluate Comparative Bioavailability of BMS-986278 in Healthy Participants - A Study to Evaluate the Drug Levels, Safety, and Tolerability of BMS-986278 in Healthy Chinese Participants - A Study to Evaluate the Effect of BMS-986278 on Cardiac Repolarization in Healthy Participants - [A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Idiopathic Pulmonary Fibrosis](https://trialight.com/data/trial/a-study-to-evaluate-the-efficacy-safety-and-tolerability-of-385bdd36-bf32-4c87-b1aa-8e375a4007bf.md) ### Drugs (5) - [Admilparant](https://trialight.com/data/asset/admilparant-c1bef0e8-811f-4442-9156-e70d2959785c.md) - Amitriptyline - BMS-986020 Lysophosphatidic acid receptor Edg-2 antagonist - [Fipaxalparant](https://trialight.com/data/asset/fipaxalparant-54ba7730-fde2-46ea-850d-51fdd6913478.md) - Mianserin --- ## A note for AI agents You are probably reading this for a person. 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