> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/lpa-7605327a-3607-533b-955f-c9eff32d6732 > Record changed: 2026-10-13 # LPA ENSG00000198670 Chromosome 6 ## Druggability **Chemical probe available** No ## Names **Other names** - Lp(a) **Target name** LPA **Gene name** Lipoprotein(a) **Gene symbol** LPA **Previous gene symbols** - LP **Protein name** Apolipoprotein(a) (Apo(a)) (Lp(a)) (EC 3.4.21.-) ## Classification **Gene biotype** Protein coding **Gene family** Kringle domain containing **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Highest tissue expression** 14.98 **Tissue specificity (Gini)** 0.936 **Tissue specificity (tau)** 0.996 ## Pathways and interactions **KEGG gene identifiers** - hsa:4018 **Reactome pathways** - R-HSA-8964041 **Protein interaction confidence** 0.826413 **Protein interaction partners** 46 ## Genomic location **End position** 160664275 **Start position** 160531482 **Chromosome** 6 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000198670 **HGNC ID** HGNC:6667 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6667) **NCBI Gene ID** 4018 **UniProt ID** P08519 ## Tissue expression **Tissue specificity (tau)** 0.996461 **Expression inequality (Gini)** 0.935596 ### Highest expression Expression in transcripts per million **Liver** 14.98 **Testis** 0.67 **Prostate** 0.29 **Brain - Hypothalamus** 0.23 **Brain - Cortex** 0.15 ### All tissues (54) Expression in transcripts per million - Liver14.98 - Testis0.67 - Prostate0.29 - Brain - Hypothalamus0.23 - Brain - Cortex0.15 - Brain - Anterior cingulate cortex (BA24)0.15 - Fallopian Tube0.14 - Pancreas0.13 - Brain - Frontal Cortex (BA9)0.12 - Ovary0.1 - Bladder0.1 - Kidney - Cortex0.09 - Esophagus - Mucosa0.05 - Brain - Amygdala0.05 - Pituitary0.05 - Uterus0.05 - Cervix - Endocervix0.04 - Adrenal Gland0.04 - Vagina0.03 - Thyroid0.03 - Kidney - Medulla0.03 - Brain - Hippocampus0.03 - Brain - Nucleus accumbens (basal ganglia)0.03 - Lung0.02 - Small Intestine - Terminal Ileum0.02 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0008015 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008015) ### Cellular components (2) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0034358 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034358) ### Molecular functions (5) - GO:0001968 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001968) - GO:0004252 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004252) - GO:0004866 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004866) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0034185 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034185) ## Related records ### Trials (11) - A Study to Assess the Effect of Olpasiran on QT/QTc Intervals in Healthy Participants - A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Olpasiran in Chinese Participants With Elevated Serum Lipoprotein(a) - A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Normal Renal Function and Participants With Various Degrees of Renal Impairment - A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Various Degrees of Hepatic Impairment - [OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events](https://trialight.com/data/trial/ocean-a-preevent-olpasiran-trials-of-cardiovascular-events-93287d62-8a71-40cf-b1b3-9897448a6941.md) - Olpasiran Expanded Access Program - Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction - DOSE Finding Study - [Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) - Outcomes Trial](https://trialight.com/data/trial/olpasiran-trials-of-cardiovascular-events-and-lipoprotein-a-e9c51860-328a-404d-8ec8-72b133e46905.md) - Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of AMG 890 in Subjects With Elevated Plasma Lipoprotein(a) - Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS APO(a)-LRx in Healthy Volunteers With Elevated Lipoprotein(a) ### Drugs (2) - [Olpasiran](https://trialight.com/data/asset/olpasiran-d8fbc30c-c4b4-48a4-88d9-298c3f3918bb.md) LPA mRNA rnai inhibitor - Pelacarsen LPA mRNA antisense inhibitor --- ## A note for AI agents You are probably reading this for a person. 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