> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/lipf-ea841999-96e6-5c4e-a1c5-e9d049702859 > Record changed: 2026-10-13 # LIPF ENSG00000182333 Target class Enzyme Chromosome 10 Approved drugs 1 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Target name** LIPF **Gene name** Lipase F, gastric type **Gene symbol** LIPF **Protein name** Gastric triacylglycerol lipase (GL) (Gastric lipase) (EC 3.1.1.3) ### Other names (2) - HGL - HLAL ## Classification **Gene biotype** Protein coding **Gene family** Lipases **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 23 **Highest tissue expression** 28,812.8 **Tissue specificity (Gini)** 0.981 **Tissue specificity (tau)** 1 ## Pathways and interactions **KEGG gene identifiers** - hsa:8513 **Reactome pathways** - R-HSA-192456 **Protein interaction confidence** 0.876474 **Protein interaction partners** 19 ## Genomic location **End position** 88678814 **Start position** 88664441 **Chromosome** 10 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000182333 **HGNC ID** HGNC:6622 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6622) **NCBI Gene ID** 8513 **UniProt ID** P07098 ## Cellular location - Secreted . ## Tissue expression **Tissue specificity (tau)** 0.999961 **Expression inequality (Gini)** 0.980501 ### Highest expression Expression in transcripts per million **Stomach** 28,812.8 **Cervix - Ectocervix** 4.98 **Testis** 4.33 **Fallopian Tube** 4.12 **Pituitary** 3.72 ### All tissues (54) Expression in transcripts per million - Stomach28,812.8 - Cervix - Ectocervix4.98 - Testis4.33 - Fallopian Tube4.12 - Pituitary3.72 - Bladder2.91 - Cervix - Endocervix2.49 - Spleen2.46 - Uterus2.19 - Esophagus - Mucosa2.07 - Ovary2.04 - Small Intestine - Terminal Ileum1.79 - Brain - Cerebellum1.76 - Adrenal Gland1.75 - Pancreas1.72 - Vagina1.68 - Liver1.66 - Kidney - Medulla1.64 - Prostate1.5 - Colon - Transverse1.33 - Esophagus - Gastroesophageal Junction1.21 - Thyroid1.2 - Minor Salivary Gland1.05 - Esophagus - Muscularis0.95 - Artery - Aorta0.9 And 29 more, listed on the interactive page. ## Biological functions ### Molecular functions (2) - GO:0004806 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004806) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (65) - A Low-Carbohydrate, Ketogenic Diet Versus Orlistat for Weight Loss - A Phase 1 Study to Evaluate EMP22 PD and EMP16 PK Versus Xenical® in Healthy Volunteers - A Pilot Study of the Efficacy of Alli in the Management of Pre-operative Weight Loss Required for Bariatric Surgery. - A Proof of Concept Trial in Overweight and Obese Patients, Investigating Effect of EMP16-02 on Body Weight (Primary) - A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America - A Study of Xenical (Orlistat) in Overweight and Obese Adolescents - A Study to Assess the Pharmacologic Equivalence of Two Orlistat Dosage Forms - A Trial With EMP16 in Preparation for Late Phase Studies - Adding Guided Self-Help Group Therapy to the Alli Weight Loss Program in Treating Binge Eating Disorder - Aggressive Treatment of Metabolic Syndrome in Patients Receiving Clozapine for Schizophrenia - An RCT of Metformin Vs Orlistat in Obese Anovulatory Women - Anti-obesity Effects of Dandelion (Taraxacum Officinale L.) - Assess the Additional Weight Loss Effect of Orlistat Used in Combination With Sibutramine - Combinatorial Therapy for Peristent Type 2 Diabetes After Gastric Banding - Comparison of MAG and Fish Oil Efficacy - Development of Rational Ways of Medical and Non-medical Treatment Methods for Metabolic Syndrome - Double-Blind, Multi-Center, Randomized Study to Assess the Efficacy and Safety of Velneperit (S-2367) and Orlistat Administered Individually or Combined With a Reduced Calorie Diet (RCD) in Obese Subjects - Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity - Effect of Orlistat in Body Composition - Effect of Orlistat on Metabolic and Hormonal Features in Women With Polycystic Ovary Syndrome (PCOS): a Randomized Controlled Clinical Trial ### Drugs (2) - Cetilistat Gastric lipase inhibitor - [Orlistat](https://trialight.com/data/asset/orlistat-efe96c73-de97-4970-9f8d-0c5633a8b660.md) Gastric lipase inhibitor --- ## A note for AI agents You are probably reading this for a person. 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