> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/lhcgr-b05eb9a7-81b7-55ff-9199-87b67bebb470 > Record changed: 2026-11-04 # LHCGR ENSG00000138039 Target class GPCR Chromosome 2 Approved drugs 5 Clinical candidates (approved and in development) 5 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 5 ## Druggability **Chemical probe available** Yes ## Names **Target name** LHCGR **Gene name** Luteinizing hormone/choriogonadotropin receptor **Gene symbol** LHCGR **Previous gene symbols** - HHG **Protein name** Lutropin-choriogonadotropic hormone receptor (LH/CG-R) (Luteinizing hormone receptor) (LHR) (LSH-R) ### Other names (4) - LHR - LCGR - LGR2 - ULG5 ## Classification **Gene biotype** Protein coding **Gene family** Glycoprotein hormone receptors **Target class** GPCR **Target type** Human gene ## Expression and localisation **Tissues expressed in** 4 **Protein localisation evidence grade** Supported **Highest tissue expression** 5.24 **Tissue specificity (Gini)** 0.813 **Tissue specificity (tau)** 0.949 ## Pathways and interactions **KEGG gene identifiers** - hsa:3973 **Protein interaction confidence** 0.827415 **Protein interaction partners** 41 ### Reactome pathways (2) - R-HSA-375281 - R-HSA-418555 ## Genomic location **End position** 48755730 **Start position** 48686774 **Chromosome** 2 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000138039 **HGNC ID** HGNC:6585 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6585) **NCBI Gene ID** 3973 **UniProt ID** P22888 ## Cellular location - Cell membrane - Multi-pass membrane protein . - Plasma membrane ### Publication evidence - PubMed 11847099 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11847099/) ## Tissue expression **Tissue specificity (tau)** 0.949121 **Expression inequality (Gini)** 0.813199 ### Highest expression Expression in transcripts per million **Nerve - Tibial** 5.24 **Esophagus - Muscularis** 4.56 **Ovary** 1.92 **Esophagus - Gastroesophageal Junction** 1.7 **Testis** 0.87 ### All tissues (54) Expression in transcripts per million - Nerve - Tibial5.24 - Esophagus - Muscularis4.56 - Ovary1.92 - Esophagus - Gastroesophageal Junction1.7 - Testis0.87 - Adipose - Subcutaneous0.74 - Adipose - Visceral (Omentum)0.66 - Bladder0.38 - Breast - Mammary Tissue0.35 - Thyroid0.31 - Pituitary0.28 - Adrenal Gland0.22 - Skin - Sun Exposed (Lower leg)0.19 - Colon - Sigmoid0.18 - Esophagus - Mucosa0.15 - Skin - Not Sun Exposed (Suprapubic)0.1 - Artery - Aorta0.09 - Artery - Coronary0.09 - Brain - Hypothalamus0.08 - Lung0.08 - Prostate0.08 - Cervix - Endocervix0.08 - Uterus0.07 - Brain - Substantia nigra0.07 - Brain - Caudate (basal ganglia)0.07 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (7) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0007187 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007187) - GO:0008584 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008584) - GO:0030539 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030539) - GO:0042700 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042700) - GO:0050890 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050890) - GO:0071373 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071373) ### Cellular components (2) - GO:0005768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions - GO:0004964 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004964) ## Related records ### Trials (263) - A Clinical Trial to Determine the Effect of Lutropin Alfa on Embryo Quality and Implantation Rate in Advanced Reproductive Age - A Phase 2 Trial to Evaluate if Corifollitropin Alfa (Org 36286), Followed by a Low Daily Dose of hCG or Recombinant FSH Can Induce Monofollicular Growth in Women With WHO Group II Anovulatory Infertility (P05693) - A Phase II Study to Assess the Efficacy and Safety of Luveris® (Lutropin Alfa) in Mid Follicular Phase for Controlled Ovarian Stimulation (COS) in Advanced Reproductive Age - A Proof of Concept Study of Serum Progesterone Levels for IVF/ICSI Following HCG Trigger for Oocyte Maturation - A Prospective Study to Evaluate the Addition of Subcutaneous Recombinant Human-Luteinizing Hormone With Recombinant Human-Follicle Stimulating Hormone on Follicular Development in Women Undergoing Ovarian Stimulation for Assisted Reproductive Technologies - A Randomised, Phase II, Comparative Study With a Parallel Control for Evaluating the Efficacy and Safety of Combined Treatment of Lutropin Alpha and Recombinant Human Luteinizing Hormone in the Middle of the Controlled Ovarian Stimulation Follicular Phase in Women With Reduced Ovarian Reserve - A Randomized Controlled Study of Different Trigger Modes of Antagonist Regimen in Patients With Low Ovarian Reserve - A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trial - A Study Comparing MENOPUR in a Pen Formulation With a Powder and Solvent Formulation in Healthy Women - A Study of Human Chorionic Gonadotrophin as Luteal Phase Support in Frozen Embryo Transfer - A Study of the Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adult Men With Hypogonadotropic Hypogonadism (HH) (P07937) - A Study of the Efficacy and Safety of Highly Purified Menotrophin Versus Recombinant Follitropin Alfa - A Study on Efficacy and Safety of Menopur® Multidose in Korean Female Patients With Infertility - A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA) - A Study to Compare the Safety and Efficacy of Cetrotide® 3 Milligram (mg) Versus Antagon™ in Women Undergoing Ovarian Stimulation - A Study to Evaluate Safety and Efficacy of Recombinant Human Luteinizing Hormone (r-hLH) Compared With Urinary Human Chorionic Gonadotrophin (u-hCG) to Trigger Ovulation in Infertile Women - A Study to Investigate the Efficacy and Safety of a Single Injection of Corifollitropin Alfa (Organon 36286) for Ovarian Stimulation Using Daily Recombinant Follicle Stimulating Hormone (FSH) as Reference (P05787) - A Study to Measure Relationship Between Antimüllerian Hormone and Initial Dose of Menopur® - A Study Using Recombinant Human Luteinizing Hormone (r-hLH, Luveris®) in the Treatment of Chinese Women With Hypogonadotropic Hypogonadism - A Trial to Compare the Efficacy and Safety of Ovarian Stimulation With GONAL-f® and Luveris® Starting on Day 1 Versus Day 6 in Women Undergoing Assisted Reproductive Technique ### Drugs (5) - [Choriogonadotropin alfa](https://trialight.com/data/asset/choriogonadotropin-alfa-363525eb-927a-43ad-bd66-8aa43bafffa9.md) Luteinizing hormone/Choriogonadotropin receptor agonist - Gonadotropin, chorionic Luteinizing hormone/Choriogonadotropin receptor agonist - LH (menotropins) Luteinizing hormone/Choriogonadotropin receptor agonist - Lutropin alfa Luteinizing hormone/Choriogonadotropin receptor agonist - Menotropins Luteinizing hormone/Choriogonadotropin receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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