> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/lgr5-eb2cf1eb-2d55-5b2c-aad6-6bbd3e4b192d > Record changed: 2026-11-04 # LGR5 ENSG00000139292 Target class Unclassified protein Chromosome 12 ## Druggability **Chemical probe available** No ## Names **Target name** LGR5 **Gene name** Leucine rich repeat containing G protein-coupled receptor 5 **Gene symbol** LGR5 **Protein name** Leucine-rich repeat-containing G-protein coupled receptor 5 (G-protein coupled receptor 49) (G-protein coupled receptor 67) (G-protein coupled receptor HG38) ### Other names (2) - HG38 - FEX ### Previous gene symbols (2) - GPR67 - GPR49 ## Classification **Gene biotype** Protein coding **Gene family** G protein-coupled receptors, Class A orphans **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 23 **Protein localisation evidence grade** Approved **Highest tissue expression** 15.33 **Tissue specificity (Gini)** 0.655 **Tissue specificity (tau)** 0.899 ## Pathways and interactions **KEGG gene identifiers** - hsa:8549 **Reactome pathways** - R-HSA-4641263 **Protein interaction confidence** 0.834542 **Protein interaction partners** 24 ## Genomic location **End position** 71586310 **Start position** 71439797 **Chromosome** 12 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000139292 **HGNC ID** HGNC:4504 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:4504) **NCBI Gene ID** 8549 **UniProt ID** O75473 ## Cellular location - Cell membrane - Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane - Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans-Golgi network may be the result of phosphorylation at Ser-861 and Ser-864 - however, the phosphorylation event has not been proven (PubMed:23439653). . - Basal body - Centrosome - Nucleoplasm - Primary cilium transition zone - Vesicles ### Publication evidence - PubMed 23439653 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23439653/) ## Tissue expression **Tissue specificity (tau)** 0.899396 **Expression inequality (Gini)** 0.654776 ### Highest expression Expression in transcripts per million **Muscle - Skeletal** 15.33 **Brain - Spinal cord (cervical c-1)** 14.81 **Nerve - Tibial** 7.22 **Small Intestine - Terminal Ileum** 5.88 **Skin - Sun Exposed (Lower leg)** 4.33 ### All tissues (54) Expression in transcripts per million - Muscle - Skeletal15.33 - Brain - Spinal cord (cervical c-1)14.81 - Nerve - Tibial7.22 - Small Intestine - Terminal Ileum5.88 - Skin - Sun Exposed (Lower leg)4.33 - Artery - Aorta3.96 - Fallopian Tube3.73 - Brain - Substantia nigra3.66 - Brain - Hippocampus2.72 - Minor Salivary Gland2.54 - Skin - Not Sun Exposed (Suprapubic)2.42 - Artery - Tibial2.38 - Brain - Hypothalamus2.22 - Adipose - Subcutaneous1.89 - Adrenal Gland1.78 - Colon - Transverse1.77 - Ovary1.48 - Brain - Amygdala1.47 - Breast - Mammary Tissue1.3 - Brain - Caudate (basal ganglia)1.3 - Lung1.18 - Brain - Putamen (basal ganglia)1.09 - Brain - Cortex1.01 - Brain - Frontal Cortex (BA9)0.95 - Artery - Coronary0.91 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0007186 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007186) - GO:0090263 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090263) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0032588 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032588) ### Molecular functions (3) - GO:0004888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888) - GO:0004930 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004930) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (6) - A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2) - A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1) - A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors - Study of Petosemtamab Plus Chemotherapy Versus Cetuximab or Bevacizumab Plus Chemotherapy in RAS and BRAF Wild Type, Recurrent, Unresectable or Metastatic Colorectal Cancer (LiGeR-CRC2) - [Study of Petosemtamab Plus Chemotherapy Versus Cetuximab Plus Chemotherapy in RAS and BRAF Wild-type, Unresectable or Metastatic, Left-sided Colorectal Cancer (LiGeR-CRC1)](https://trialight.com/data/trial/study-of-petosemtamab-plus-chemotherapy-versus-cetuximab-964c0b27-9b27-451c-956a-7c117ada623b.md) - Study to Investigate Petosemtamab in Adults With Metastatic Non-Small Cell Lung Cancer ### Drugs (1) - [Petosemtamab](https://trialight.com/data/asset/petosemtamab-661ba63c-03d6-4a61-bfb8-83dbf0a9cf89.md) --- ## A note for AI agents You are probably reading this for a person. 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