> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/lepr-e64d0b1f-f2f9-59a4-9ae4-f6871c5f5e34 > Record changed: 2026-10-13 # LEPR ENSG00000116678 Target class Unclassified protein Chromosome 1 Approved drugs 1 Clinical candidates (approved and in development) 2 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 2 ## Druggability **Chemical probe available** No ## Names **Target name** LEPR **Gene name** Leptin receptor **Gene symbol** LEPR **Protein name** Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295) ### Other names (4) - OBR - CD295 - LEP-R - OB-R ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Immunoglobulin like domain containing **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 48 **Protein localisation evidence grade** Approved **Highest tissue expression** 24.92 **Tissue specificity (Gini)** 0.484 **Tissue specificity (tau)** 0.812 ## Pathways and interactions **KEGG gene identifiers** - hsa:3953 **Protein interaction confidence** 0.805393 **Protein interaction partners** 56 ## Genomic location **End position** 65641559 **Start position** 65420652 **Chromosome** 1 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000116678 **HGNC ID** HGNC:6554 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6554) **NCBI Gene ID** 3953 **UniProt ID** P48357 ## Cellular location - Cell membrane - Single-pass type I membrane protein . Basolateral cell membrane . - SUBCELLULAR LOCATION: \[Isoform E\]: Secreted . - Basal body - Cytosol - Plasma membrane - Primary cilium - Vesicles ### Publication evidence - PubMed 19159218 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/19159218/) ## Tissue expression **Tissue specificity (tau)** 0.811752 **Expression inequality (Gini)** 0.4842 ### Highest expression Expression in transcripts per million **Nerve - Tibial** 24.92 **Ovary** 16.09 **Lung** 13.15 **Breast - Mammary Tissue** 12.94 **Uterus** 11.86 ### All tissues (54) Expression in transcripts per million - Nerve - Tibial24.92 - Ovary16.09 - Lung13.15 - Breast - Mammary Tissue12.94 - Uterus11.86 - Cervix - Endocervix11.75 - Liver11.44 - Adipose - Visceral (Omentum)10.03 - Artery - Coronary9.57 - Cervix - Ectocervix9.55 - Thyroid8.78 - Artery - Tibial8.45 - Fallopian Tube8.42 - Adipose - Subcutaneous8.07 - Minor Salivary Gland7.39 - Cells - Cultured fibroblasts6.96 - Artery - Aorta6.67 - Stomach6.66 - Prostate4.9 - Esophagus - Gastroesophageal Junction4.9 - Skin - Not Sun Exposed (Suprapubic)4.83 - Bladder4.8 - Esophagus - Muscularis4.51 - Vagina4.12 - Pituitary3.89 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0001525 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001525) - GO:0006112 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006112) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0007275 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007275) - GO:0010507 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010507) - GO:0033210 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033210) - GO:0051049 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051049) - GO:0097696 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097696) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0016323 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016323) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) ### Molecular functions (4) - GO:0004888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0017046 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0017046) - GO:0038021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038021) ## Related records ### Trials (37) - A Study Evaluating Mibavademab Treatment of Obesity Due to Leptin (LEP) Gene Mutations in Children, Adolescents and Adults - A Study of the Functional Magnetic Resonance Imaging Response to Leptin and Pramlintide - A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD) - [A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity](https://trialight.com/data/trial/a-study-of-tirzepatide-ly3298176-plus-mibavademab-compared-c3557fe0-b823-4551-acf4-9132fd6d2ef2.md) - A Study to Evaluate the Effect on Body Weight of Leptin Administered in Conjunction With Pramlintide in Overweight and Obese Subjects - A Study to Examine the Effects of the Leptin Receptor (LEPR) Agonist Antibody REGN4461 in Adult Patients With Familial Partial Lipodystrophy (FPLD) - A Study To Examine The Efficacy And Safety Of Pramlintide+Metreleptin In Obese Subjects - A Study to Examine the Safety, Tolerability and Biological Effects of REGN4461 in Healthy Volunteers - A Study to Investigate Mibavademab in Adult Women With Functional Hypothalamic Amenorrhea - Clinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With Lipodystrophy - CLINICAL PROTOCOL to Investigate the Long-term Safety and Efficacy of Metreleptin in Various Forms of Partial Lipodystrophy - Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy - Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy - Effect of Metreleptin Therapy in the Treatment of Severe Insulin Resistance - Efficacy and Safety of Mibavademab in Adult and Pediatric Patients With Generalized Lipodystrophy - Evaluation of Safety and Efficiency of Metreleptin Treatment for Patients With Multiple Symmetric Lipomatosis (MSL) - Expanded Access for Metreleptin for the Treatment of Diabetes Mellitus and/or Hypertriglyceridemia Associated With Lipodystrophy - Expanded Access Metreleptin Study - Expanded Access to REGN4461 for Patients With Diseases Associated With Deficient Leptin Signaling - Extension Study of Protocol DFA102 to Examine the Long-Term Safety, Tolerability, and Effect on Body Weight of Pramlintide Administered in Combination With Metreleptin ### Drugs (2) - Metreleptin Leptin receptor agonist - [Mibavademab](https://trialight.com/data/asset/mibavademab-2c530b5c-9ec4-4d42-aff7-3454ecd7d355.md) Leptin receptor agonist --- ## A note for AI agents You are probably reading this for a person. 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