> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/lck-932d728d-9505-5399-ab8c-4e9818314abd
> Record changed: 2026-11-04

# LCK

ENSG00000182866

Target class

Kinase

Chromosome

1

Approved drugs

2

Clinical candidates (approved and in development)

7

## Clinical evidence

**Approved drugs**

2

**ClinGen gene-disease validity**

Definitive

**Clinical candidates (approved and in development)**

7

## Druggability

**Chemical probe available**

Yes

## Names

**Target name**

LCK

**Gene name**

LCK proto-oncogene, Src family tyrosine kinase

**Gene symbol**

LCK

**Protein name**

Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)

## Classification

**Gene biotype**

Protein coding

**Gene family**

SH2 domain containing|Src family tyrosine kinases

**Target class**

Kinase

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

29

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

101.95

**Tissue specificity (Gini)**

0.804

**Tissue specificity (tau)**

0.962

## Pathways and interactions

**KEGG gene identifiers**

- hsa:3932

### Reactome pathways (23)

- R-HSA-114604
- R-HSA-1257604
- R-HSA-1433557
- R-HSA-1433559
- R-HSA-164944
- R-HSA-167590
- R-HSA-202424
- R-HSA-202427
- R-HSA-202430
- R-HSA-202433
- R-HSA-210990
- R-HSA-2219530
- R-HSA-2424491
- R-HSA-389356
- R-HSA-389357
- R-HSA-389359
- R-HSA-389513
- R-HSA-389948
- R-HSA-6811558
- R-HSA-9013407
- R-HSA-9020558
- R-HSA-9670439
- R-HSA-9706374

## Genomic location

**End position**

32286170

**Start position**

32251244

**Chromosome**

1

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000182866

**HGNC ID**

HGNC:6524

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6524)

**NCBI Gene ID**

3932

**UniProt ID**

P06239

## Cellular location

- Cell membrane
- Lipid-anchor
- Cytoplasmic side . Cytoplasm, cytosol . Note=Present in lipid rafts in an inactive form. .
- Golgi apparatus

### Publication evidence (2)

- PubMed 12218089  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12218089/)
- PubMed 22034844  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22034844/)

## Tissue expression

**Tissue specificity (tau)**

0.961639

**Expression inequality (Gini)**

0.803564

### Highest expression

Expression in transcripts per million

**Cells - EBV-transformed lymphocytes**

101.95

**Spleen**

52.7

**Whole Blood**

47.71

**Small Intestine - Terminal Ileum**

20.15

**Lung**

13.78

### All tissues (54)

Expression in transcripts per million

- Cells - EBV-transformed lymphocytes101.95
- Spleen52.7
- Whole Blood47.71
- Small Intestine - Terminal Ileum20.15
- Lung13.78
- Thyroid4.31
- Colon - Transverse4.31
- Fallopian Tube3.88
- Adipose - Visceral (Omentum)3.88
- Cervix - Endocervix3.8
- Prostate3.76
- Vagina3.56
- Kidney - Medulla3.47
- Stomach3.07
- Bladder2.95
- Cervix - Ectocervix2.84
- Esophagus - Mucosa2.6
- Adipose - Subcutaneous2.3
- Minor Salivary Gland2.28
- Uterus2.16
- Artery - Coronary2.09
- Breast - Mammary Tissue1.87
- Artery - Aorta1.72
- Liver1.61
- Nerve - Tibial1.51

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (15)

- GO:0009410  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009410)
- GO:0030168  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030168)
- GO:0030217  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030217)
- GO:0031295  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031295)
- GO:0034116  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034116)
- GO:0035556  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035556)
- GO:0038094  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038094)
- GO:0042110  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042110)
- GO:0050852  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050852)
- GO:0050870  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050870)
- GO:0050900  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050900)
- GO:0051132  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051132)
- GO:0160162  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0160162)
- GO:1903039  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903039)
- GO:2001244  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2001244)

### Cellular components (7)

- GO:0000242  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000242)
- GO:0001772  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001772)
- GO:0005737  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)
- GO:0045121  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121)
- GO:0070062  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062)

### Molecular functions (16)

- GO:0001784  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001784)
- GO:0004713  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713)
- GO:0004715  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004715)
- GO:0004722  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004722)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0016004  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016004)
- GO:0019901  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901)
- GO:0019903  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019903)
- GO:0042169  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042169)
- GO:0042608  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042608)
- GO:0042609  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042609)
- GO:0042610  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042610)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)
- GO:0043274  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043274)
- GO:0043548  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043548)
- GO:0051117  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051117)

## Off-target safety

- T cell activation  
### Effects

  - Activation/Increase/Upregulation: general  
### Studies

  - preclinical: T cell activation  
### Biological samples

  - Immune  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- SCID-like immunodeficiency  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: SCID-like immunodeficiency  
### Biological samples

  - Immune  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)
- T cell inhibition  
### Effects

  - Inhibition/Decrease/Downregulation: general  
### Studies

  - preclinical: T cell inhibition  
### Biological samples

  - Immune  
PubMed 23197038  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23197038/)

## Related records

### Trials (1,163)

- \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer
- 12 Week Patient Study in Neovascular Age-related Macular Degeneration (AMD)
- A Bioequivalence Study of Dasatinib Tablet
- A BIOmarker Driven Trial With Nivolumab and Ipilimumab or VEGFR tKi in Naïve Metastatic Kidney Cancer
- A Clincal Study of Max-40279-01 in Patients With Advanced Colorectal Cancer
- A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST
- A Clinical Trial of Buparlisib and Ibrutinib in Lymphoma
- A Combination Clinical Study of PLX3397 and Pembrolizumab To Treat Advanced Melanoma and Other Solid Tumors
- A Combination of Acalabrutinib With R-CHOP for Patient Diffuse Large B-cell Lymphoma (DLBCL)
- A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312)
- A Combination of Pazopanib and Carboplatin in Advanced Solid Malignancies
- A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma
- A Crossover Study to Evaluate the Bioavailability of Ibrutinib Suspension and Sprinkle Formulations Compared to Capsules in Healthy Adults
- A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420.
- A Drug Interaction Study to Assess the Effect of Omeprazole on the Pharmacokinetics of Ibrutinib in Healthy Adults
- A Long-term Extension Study of PCI-32765 (Ibrutinib)
- A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Lymphomas
- A Multi-Center Study of Ibrutinib in Combination With MEDI4736 in Subjects With Relapsed or Refractory Solid Tumors
- A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)
- A Multicenter Phase 2 Study of Ibrutinib in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) With 17p Deletion

### Drugs (16)

- [Acalabrutinib](https://trialight.com/data/asset/acalabrutinib-17f298f9-e056-45ab-95dc-9a5b0f25c869.md)
- Dasatinib
- Dasatinib anhydrous SRC inhibitor
- Dasatinib laurylsulfate SRC inhibitor
- ENMD-981693 SRC inhibitor
- [Ibrutinib](https://trialight.com/data/asset/ibrutinib-0b3ac4fd-6e98-4847-a711-2f599e8bb93d.md)
- Ilorasertib SRC inhibitor
- JNJ-26483327 Tyrosine-protein kinase LCK inhibitor
- Nefextinib
- Pazopanib Tyrosine-protein kinase LCK inhibitor
- Pazopanib hydrochloride Tyrosine-protein kinase LCK inhibitor
- Pexidartinib
- Saracatinib
- TAK-020
- TG100-801 SRC inhibitor
- XL-228 SRC inhibitor

---

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