> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/lats1-23798e46-1bc7-5a8c-9e1d-e5441c833025 > Record changed: 2026-11-04 # LATS1 ENSG00000131023 Target class Kinase Chromosome 6 ## Druggability **Chemical probe available** No ## Names **Other names** - WARTS **Target name** LATS1 **Gene name** Large tumor suppressor kinase 1 **Gene symbol** LATS1 **Protein name** Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) ## Classification **Gene biotype** Protein coding **Gene family** Large tumor suppressor kinase family **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Highest tissue expression** 18.94 **Tissue specificity (Gini)** 0.281 **Tissue specificity (tau)** 0.49 ## Pathways and interactions **KEGG gene identifiers** - hsa:9113 **Reactome pathways** - R-HSA-2028269 **Protein interaction confidence** 0.8965 **Protein interaction partners** 32 ## Genomic location **End position** 149718105 **Start position** 149658153 **Chromosome** 6 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000131023 **HGNC ID** HGNC:6514 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6514) **NCBI Gene ID** 9113 **UniProt ID** O95835 ## Cellular location - Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Midbody . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. . ### Publication evidence - PubMed 10518011 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10518011/) ## Tissue expression **Tissue specificity (tau)** 0.490486 **Expression inequality (Gini)** 0.281252 ### Highest expression Expression in transcripts per million **Ovary** 18.94 **Uterus** 18.57 **Cervix - Ectocervix** 18.33 **Cervix - Endocervix** 17.95 **Brain - Cerebellar Hemisphere** 17.18 ### All tissues (54) Expression in transcripts per million - Ovary18.94 - Uterus18.57 - Cervix - Ectocervix18.33 - Cervix - Endocervix17.95 - Brain - Cerebellar Hemisphere17.18 - Nerve - Tibial16.12 - Brain - Cerebellum15.86 - Fallopian Tube15.41 - Artery - Tibial14.68 - Cells - Cultured fibroblasts14.23 - Vagina14.17 - Bladder13.9 - Cells - EBV-transformed lymphocytes13.47 - Artery - Coronary13.23 - Adipose - Subcutaneous13.07 - Artery - Aorta13 - Colon - Sigmoid13 - Breast - Mammary Tissue12.87 - Prostate12.76 - Thyroid12.49 - Lung12.13 - Esophagus - Gastroesophageal Junction11.88 - Esophagus - Muscularis11.77 - Testis11.11 - Skin - Sun Exposed (Lower leg)10.78 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (13) - GO:0000086 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000086) - GO:0000819 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000819) - GO:0006468 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006468) - GO:0030833 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030833) - GO:0033146 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033146) - GO:0035329 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035329) - GO:0043254 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043254) - GO:0045736 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045736) - GO:0060644 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060644) - GO:0090090 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0090090) - GO:1900181 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900181) - GO:1900227 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1900227) - GO:2000058 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:2000058) ### Cellular components (5) - GO:0000922 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000922) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005815 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005815) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0030496 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030496) ### Molecular functions (7) - GO:0000287 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000287) - GO:0004674 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004674) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005524 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005524) - GO:0019901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901) - GO:0030331 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030331) - GO:0106310 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0106310) ## Related records ### Trials (576) - (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors - 5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours - A BIOmarker Driven Trial With Nivolumab and Ipilimumab or VEGFR tKi in Naïve Metastatic Kidney Cancer - A Comparison of Vorolanib Tablets Combined With Everolimus Versus Sunitinib in Patients With Advanced Renal Cell Carcinoma Who Have Progressed After Treatment With Immunotherapy Monotherapy or in Combination With TKI - A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study. - A CpG-methylation-based Assay for Stratifying Stage III Clear Cell Renal Cell Carcinoma of Receiving Adjuvant Treatment - A Dose Escalation Study of BIBF 1120 Together With Paclitaxel and Carboplatin in Patients With Advanced Stage Non-small-cell Lung Cancer - A Dose-escalation Study of BIBF 1120 in Japanese Patients With Advanced Solid Tumours - A Drug-Drug Interaction Study of ENV-101 (Taladegib) on Nintedanib Pharmacokinetics in Healthy Subjects - A Follow-up Study Investigating Long Term Treatment With Nintedanib in Patients With Progressive Fibrosing Interstitial Lung Disease (PF-ILD) - A Global Study of Midostaurin in Combination With Chemotherapy to Evaluate Safety, Efficacy and Pharmacokinetics in Newly Diagnosed Pediatric Patients With FLT3 Mutated AML - A Global Study of the Efficacy and Safety of Midostaurin + Chemotherapy in Newly Diagnosed Patients With FLT3 Mutation Negative (FLT3-MN) Acute Myeloid Leukemia (AML) - A Multi-centre 3-arm Randomised Phase II Trial of BIBF 1120 Versus BIBW 2992 Versus Sequential Administration of BIBF 1120 and BIBW 2992 in Patients With Hormone-resistant Prostate Cancer - [A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors](https://trialight.com/data/trial/a-phase-1-2-study-of-vs-7375-in-patients-with-kras-g12d-2a83cb8c-fe8d-4b5c-88de-0eebb2025cdc.md) - A Phase 1b Master Trial to Investigate CPX-351 in Subjects With Previously Untreated Acute Myeloid Leukemia - A Phase 1b Trial in Patients With Renal Cell Cancer - A Phase 2 Study of Avutometinib (VS-6766) Plus Defactinib - A Phase I / II Trial of Nintedanib in Asian Hepatocellular Carcinoma Patients - A Phase I Study of Bevacizumab and Sunitinib in Metastatic Renal Cell Carcinoma Patients - A Phase I Study of SUNITINIB and Rapamycin in Advanced Non-Small Cell Lung Cancer (NSCLC) ### Drugs (7) - AST-487 - [Defactinib](https://trialight.com/data/asset/defactinib-93d3f8e7-960f-4e54-9e6e-fd0a1504d053.md) - Lestaurtinib - Midostaurin - [Nintedanib](https://trialight.com/data/asset/nintedanib-00bd66fb-64cd-4ad0-93f5-373754dd9bff.md) - PF-03758309 - Sunitinib --- ## A note for AI agents You are probably reading this for a person. 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