> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/lag3-9427165f-23d0-56e2-8aec-0a1f9a15edc3 > Record changed: 2026-10-13 # LAG3 ENSG00000089692 Target class Unclassified protein Chromosome 12 Approved drugs 1 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 1 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Other names** - CD223 **Target name** LAG3 **Gene name** Lymphocyte activating 3 **Gene symbol** LAG3 **Protein name** Lymphocyte activation gene 3 protein (LAG-3) (CD antigen CD223) \[Cleaved into: Secreted lymphocyte activation gene 3 protein (sLAG-3)\] ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Immunoglobulin like domain containing **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 36 **Highest tissue expression** 39.92 **Tissue specificity (Gini)** 0.654 **Tissue specificity (tau)** 0.907 ## Pathways and interactions **KEGG gene identifiers** - hsa:3902 **Reactome pathways** - R-HSA-2132295 **Protein interaction confidence** 0.82405 **Protein interaction partners** 60 ## Genomic location **End position** 6778455 **Start position** 6772360 **Chromosome** 12 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000089692 **HGNC ID** HGNC:6476 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6476) **NCBI Gene ID** 3902 **UniProt ID** P18627 ## Cellular location - \[Lymphocyte activation gene 3 protein\]: Cell membrane - Single-pass type I membrane protein . Note=Clusters on the T-cell surface following ligand-binding. . - SUBCELLULAR LOCATION: \[Secreted lymphocyte activation gene 3 protein\]: Secreted . Note=Produced following cleavage of the main chain. . ### Publication evidence (4) - PubMed 1380059 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1380059/) - PubMed 1692078 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/1692078/) - PubMed 35761082 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35761082/) - PubMed 9634475 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9634475/) ## Tissue expression **Tissue specificity (tau)** 0.907092 **Expression inequality (Gini)** 0.653565 ### Highest expression Expression in transcripts per million **Ovary** 39.92 **Spleen** 28.08 **Cells - EBV-transformed lymphocytes** 20.16 **Uterus** 18.08 **Small Intestine - Terminal Ileum** 10.36 ### All tissues (54) Expression in transcripts per million - Ovary39.92 - Spleen28.08 - Cells - EBV-transformed lymphocytes20.16 - Uterus18.08 - Small Intestine - Terminal Ileum10.36 - Fallopian Tube8.86 - Cervix - Endocervix8.57 - Colon - Sigmoid8.28 - Testis7.06 - Vagina6.11 - Prostate5.89 - Lung5.71 - Nerve - Tibial5.62 - Esophagus - Muscularis5.09 - Colon - Transverse4.86 - Cervix - Ectocervix4.82 - Esophagus - Gastroesophageal Junction4.09 - Adipose - Visceral (Omentum)3.66 - Whole Blood3.29 - Bladder3.21 - Liver2.71 - Brain - Cerebellum2.35 - Stomach2.13 - Kidney - Medulla2.1 - Brain - Cerebellar Hemisphere1.99 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0002841 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002841) - GO:0050860 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050860) - GO:0050868 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050868) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (4) - GO:0003823 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003823) - GO:0004888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0042289 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042289) ## Related records ### Trials (175) - A Phase 1, Bioavailability Study of Relatlimab in Combination With Nivolumab - A Phase 2 Clinical Trial of Neoadjuvant Relatlimab and Nivolumab in High Risk, Clinical Stage II Cutaneous Melanoma - A Phase Ib/II Study of BYL719 and Cetuximab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma - A Phase II Platform Study to Evaluate Treatment With Cemiplimab Monotherapy or Cemiplimab Plus Fianlimab or Other Novel Combinations in Patients With Colorectal Cancer With Minimal Residual Disease Following Definitive Surgery and Chemotherapy (EMPIRE) - A Randomized Phase 2 Trial of Nivolumab, Relatlimab Plus Ipilimumab vs. Nivolumab Plus Ipilimumab in First-line Advanced Renal Cell Carcinoma (RCC) - A Randomized Phase I Study of a Hepatitis B Antigen Combined With IMP321 - A Randomized Trial of Fianlimab and Cemiplimab +/- Ipilimumab or Ipilimumab Plus Nivolumab in First-line Advanced Renal Cell Carcinoma (RCC) - A Safety and Efficacy Study of Combined Fianlimab + Cemiplimab in Children and Young Adults With Recurrent or Progressive High-Grade Glioma or Posterior Fossa-A Ependymoma - A Safety and Efficacy Trial of JCAR017 Combinations in Subjects With Relapsed/Refractory B-cell Malignancies - A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Treatment - A Study in Hormone Receptor-positive Metastatic Breast Carcinoma Patients to Test a New Schedule of Efti (IMP321, Eftilagimod Alpha) as Adjunctive to a Weekly Treatment Regimen of Paclitaxel - A Study of Biomarker-Directed, Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495) - [A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors](https://trialight.com/data/trial/a-study-of-bms-986482-alone-or-as-combination-therapy-in-6d77cbe1-5589-468b-b0ee-4b57e5d96643.md) - A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5) - A Study of Cemiplimab and Fianlimab in People With Clear Cell Renal Cell Carcinoma - A Study of Cemiplimab and Fianlimab in People With Nasopharyngeal Carcinoma - A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (MK-4280A-008) - A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007) - A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)-China Extension Study - A Study of Combination Therapies With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer (MK-3475-06A) ### Drugs (6) - Eftilagimod alfa Lymphocyte activation gene 3 protein vaccine antigen - [Favezelimab](https://trialight.com/data/asset/favezelimab-6933335b-05d1-493c-89f9-ab522b82c6d8.md) Lymphocyte activation gene 3 protein inhibitor - [Fianlimab](https://trialight.com/data/asset/fianlimab-90c791f8-25bd-4882-8311-8dd34d92ebc7.md) Lymphocyte activation gene 3 protein inhibitor - Ieramilimab Lymphocyte activation gene 3 protein inhibitor - [Relatlimab](https://trialight.com/data/asset/relatlimab-7c233520-282a-4920-8915-6376595bb1af.md) Lymphocyte activation gene 3 protein inhibitor - Tebotelimab Lymphocyte activation gene 3 protein inhibitor --- ## A note for AI agents You are probably reading this for a person. 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