> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kras-106a796f-110c-5472-9254-9049150fe0f1 > Record changed: 2026-10-13 # KRAS ENSG00000133703 Target class Enzyme Chromosome 12 Approved drugs 2 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 2 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** Yes ## Names **Target name** KRAS **Gene name** KRAS proto-oncogene, GTPase **Gene symbol** KRAS **Previous gene symbols** - KRAS2 **Protein name** GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) \[Cleaved into: GTPase KRas, N-terminally processed\] ### Other names (2) - KRAS1 - K-Ras4B ## Classification **Gene biotype** Protein coding **Gene family** RAS type GTPase family **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 54 **Protein localisation evidence grade** Supported **Highest tissue expression** 30.74 **Tissue specificity (Gini)** 0.228 **Tissue specificity (tau)** 0.575 ## Pathways and interactions **KEGG gene identifiers** - hsa:3845 **Protein interaction confidence** 0.859354 **Protein interaction partners** 206 ### Reactome pathways (9) - R-HSA-6802946 - R-HSA-6802955 - R-HSA-8951936 - R-HSA-9648002 - R-HSA-9649948 - R-HSA-9674555 - R-HSA-9680350 - R-HSA-9753510 - R-HSA-9753512 ## Genomic location **End position** 25250936 **Start position** 25205246 **Chromosome** 12 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000133703 **HGNC ID** HGNC:6407 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6407) **NCBI Gene ID** 3845 **UniProt ID** P01116 ## Cellular location - Cell membrane - Lipid-anchor - Cytoplasmic side . Endomembrane system . Cytoplasm, cytosol . - SUBCELLULAR LOCATION: \[Isoform 2B\]: Cell membrane - Lipid-anchor . - Cytosol ### Publication evidence (4) - PubMed 22431598 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22431598/) - PubMed 23698361 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23698361/) - PubMed 29239724 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/29239724/) - PubMed 28619714 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28619714/) ## Tissue expression **Tissue specificity (tau)** 0.574723 **Expression inequality (Gini)** 0.228286 ### Highest expression Expression in transcripts per million **Nerve - Tibial** 30.74 **Brain - Cerebellar Hemisphere** 25.09 **Esophagus - Muscularis** 22.17 **Esophagus - Mucosa** 21.55 **Esophagus - Gastroesophageal Junction** 20.19 ### All tissues (54) Expression in transcripts per million - Nerve - Tibial30.74 - Brain - Cerebellar Hemisphere25.09 - Esophagus - Muscularis22.17 - Esophagus - Mucosa21.55 - Esophagus - Gastroesophageal Junction20.19 - Lung19.76 - Vagina18.42 - Bladder18.35 - Colon - Transverse17.91 - Artery - Tibial17.65 - Brain - Cerebellum17.42 - Cells - EBV-transformed lymphocytes17.05 - Brain - Frontal Cortex (BA9)16.95 - Cells - Cultured fibroblasts16.8 - Uterus16.68 - Colon - Sigmoid16.64 - Small Intestine - Terminal Ileum16.59 - Skin - Sun Exposed (Lower leg)16.3 - Cervix - Ectocervix16.2 - Skin - Not Sun Exposed (Suprapubic)15.93 - Artery - Coronary15.15 - Thyroid15.03 - Stomach14.98 - Fallopian Tube14.91 - Adipose - Subcutaneous14.68 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0000165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000165) - GO:0007265 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007265) - GO:0010628 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010628) ### Cellular components (10) - GO:0000139 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0000139) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005741 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005741) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005925 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005925) - GO:0009898 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009898) - GO:0012505 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0012505) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) ### Molecular functions (3) - GO:0003924 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003924) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0044877 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044877) ## Related records ### Trials (105) - A 2-part Phase 1/2 Open-label Trial on ODM-212 - A Clinical Trial to Evaluate Bioavailability and Effect of Food for Sotorasib in Healthy Participants - [A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-159642 in Participants With Advanced Solid Tumors](https://trialight.com/data/trial/a-first-in-human-fih-study-to-evaluate-the-safety-and-6675542e-45b5-40e0-a6e8-8a1e82cb3724.md) - A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C Mutations - A Phase 1 Study of MRTX0902 in Solid Tumors With Mutations in the KRAS MAPK Pathway - A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100) - A Phase 2 Basket Trial in Which Patients With Advanced Solid Tumors Carrying the KRAS G12C mUtation Receive Treatment With a Combination of Sotorasib and Panitumumab - A Phase I Study of Adagrasib and Durvalumab for Treatment of Advanced Non-small Cell Lung Cancers and Gastro-intestinal Cancers Harboring KRAS G12C Mutations - A Phase I/II Study of AMG 510 in Combination With MVASI in Patients With Advanced, Unresectable or Metastatic KRAS G12C Mutant NSCLC With Asymptomatic Brain Metastasis - A Phase II Study of Neoadjuvant Sotorasib in Combination With Cisplatin or Carboplatin and Pemetrexed for Surgically Resectable Stage IIA-IIIB Non-Squamous Non-Small Cell Lung Cancer With a KRAS p.G12C Mutation - A PK Study to Assess the Drug-drug Interaction of a BCRP Inhibitor on Adagrasib - A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation - A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies - A Study Comparing Sotorasib With Durvalumab in People With Non-Small Cell Lung Cancer (NSCLC) - A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202) - A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer - [A Study in Healthy Volunteers to Compare the Pharmacokinetics of Sotorasib Administered as 1 or 2 Tablets](https://trialight.com/data/trial/a-study-in-healthy-volunteers-to-compare-the-721799d5-a4cc-454d-bdb5-ebdd91f826b5.md) - A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4) - A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Advanced NSCLC - A Study of BMS-986466 With Adagrasib With or Without Cetuximab in Participants With Kirsten Rat Sarcoma Virus Glycine 12 to Cysteine (KRAS G12C)-Mutant Solid Tumors ### Drugs (3) - [Adagrasib](https://trialight.com/data/asset/adagrasib-550c7524-1104-4d43-9827-298e1041dc2e.md) GTPase KRas inhibitor - Salirasib RAS inhibitor - [Sotorasib](https://trialight.com/data/asset/sotorasib-a4359290-f99a-4ef1-8cd1-9a866e8b0748.md) GTPase KRas inhibitor --- ## A note for AI agents You are probably reading this for a person. 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