> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/klrc1-a6a0a416-e9cb-5950-bbca-aa636c7cea21 > Record changed: 2026-10-13 # KLRC1 ENSG00000134545 Target class Unclassified protein Chromosome 12 Approved drugs 0 Clinical candidates (approved and in development) 1 ## Clinical evidence **Approved drugs** 0 **Clinical candidates (approved and in development)** 1 ## Druggability **Chemical probe available** No ## Names **Target name** KLRC1 **Gene name** Killer cell lectin like receptor C1 **Gene symbol** KLRC1 **Previous gene symbols** - NKG2 **Protein name** NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a) ### Other names (3) - NKG2-A - NKG2-B - CD159a ## Classification **Gene biotype** Protein coding **Gene family** CD molecules|Killer cell lectin like receptors|C-type lectin domain containing **Target class** Unclassified protein **Target type** Human gene ## Expression and localisation **Tissues expressed in** 4 **Protein localisation evidence grade** Approved **Highest tissue expression** 3.79 **Tissue specificity (Gini)** 0.599 **Tissue specificity (tau)** 0.919 ## Pathways and interactions **KEGG gene identifiers** - hsa:3821 **Reactome pathways** - R-HSA-198933 **Protein interaction confidence** 0.86034 **Protein interaction partners** 50 ## Genomic location **End position** 10454685 **Start position** 10442264 **Chromosome** 12 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000134545 **HGNC ID** HGNC:6374 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6374) **NCBI Gene ID** 3821 **UniProt ID** P26715 ## Cellular location - Cell membrane - Single-pass type II membrane protein . - Plasma membrane ### Publication evidence (2) - PubMed 12165520 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12165520/) - PubMed 20952657 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20952657/) ## Tissue expression **Tissue specificity (tau)** 0.919351 **Expression inequality (Gini)** 0.59892 ### Highest expression Expression in transcripts per million **Spleen** 3.79 **Lung** 1.54 **Small Intestine - Terminal Ileum** 1.08 **Whole Blood** 1.05 **Stomach** 0.9 ### All tissues (54) Expression in transcripts per million - Spleen3.79 - Lung1.54 - Small Intestine - Terminal Ileum1.08 - Whole Blood1.05 - Stomach0.9 - Fallopian Tube0.87 - Testis0.8 - Thyroid0.71 - Prostate0.62 - Bladder0.59 - Artery - Aorta0.55 - Minor Salivary Gland0.55 - Colon - Transverse0.52 - Adipose - Visceral (Omentum)0.51 - Vagina0.49 - Cervix - Endocervix0.44 - Brain - Spinal cord (cervical c-1)0.41 - Artery - Coronary0.36 - Esophagus - Mucosa0.29 - Breast - Mammary Tissue0.27 - Esophagus - Muscularis0.25 - Uterus0.24 - Pituitary0.24 - Adipose - Subcutaneous0.22 - Liver0.21 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0001915 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001915) - GO:0002305 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002305) - GO:0002769 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002769) - GO:0007166 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007166) - GO:0045953 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045953) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0043235 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043235) ### Molecular functions (6) - GO:0004888 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004888) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0023024 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0023024) - GO:0062080 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0062080) - GO:0062082 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0062082) - GO:1990405 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990405) ## Related records ### Trials (24) - A Dose-Ranging Study of IPH2201 in Patients With Gynecologic Malignancies - [A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer](https://trialight.com/data/trial/a-global-study-to-assess-the-effects-of-durvalumab-with-9b1ffaa8-7388-46c3-8f09-9f534f48bdb9.md) - A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors - A Trial of Durvalumab (MEDI4736) Plus Monalizumab in Non-Muscle-Invasive Bladder Cancer - Anti-NKG2A Monoclonal Antibody for AML or MDS Patients Undergoing Haploidentical Transplantation - Assessment of Efficacy and Safety of Monalizumab Plus Cetuximab Compared to Placebo Plus Cetuximab in Recurrent or Metastatic Head and Neck Cancer - Assessment of Metabolic & Path Response w/ RCT & ImT Before Surgery in Locally Advanced Esoph and Gastro-esoph Jction CA - Biomarker-based Study in R/M SCCHN - Combination Study of IPH2201 (Monalizumab) With Ibrutinib in Relapsed, Refractory or Previously Untreated CLL - Durvalumab Alone or in Combination With Novel Agents in Subjects With NSCLC - Efficacy Study of Pre-operative IPH2201 in Patients With Squamous Cell Carcinoma of the Oral Cavity - Monalizumab and MEDI5752 in Patients With MSI and/or dMMR Metastatic Cancer - Monalizumab and Trastuzumab In Metastatic HER2-pOSitive breAst Cancer: MIMOSA-trial - MOnaliZumab in Combination With durvAlumab (MEDI4736) for tRreatmenT of Small Cell Lung Cancer - [Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer](https://trialight.com/data/trial/neoadjuvant-and-adjuvant-treatment-in-resectable-non-small-c5704130-e063-4bfd-817c-edc38351eb37.md) - Neoadjuvant Durvalumab Alone or in Combination With Novel Agents in Resectable Non-Small Cell Lung Cancer - Novel Oncology Therapies in Combination With Adjuvant Chemo in High-risk MSS-CRC - Precision Immuno-Oncology for Advanced Non-small Cell Lung Cancer Patients With PD-1 ICI Resistance - Prospective Study in Patients With Advanced or Metastatic Cancer and SARS-CoV-2 Infection - Study of a Humanized Antibody Initiated 2 Months After an HLA Matched Allogenic Stem Cell Transplantation ### Drugs (1) - [Monalizumab](https://trialight.com/data/asset/monalizumab-8cc332ab-4a5a-46a1-93d5-ad31573af1d4.md) NKG2-A/NKG2-B type II integral membrane protein inhibitor --- ## A note for AI agents You are probably reading this for a person. 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