> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/klk2-72b9e2f8-6ecd-5e3a-8428-85d7b34686da > Record changed: 2026-11-04 # KLK2 ENSG00000167751 Target class Enzyme Chromosome 19 ## Druggability **Chemical probe available** No ## Names **Target name** KLK2 **Gene name** Kallikrein related peptidase 2 **Gene symbol** KLK2 **Protein name** Kallikrein-2 (EC 3.4.21.35) (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2) ## Classification **Gene biotype** Protein coding **Gene family** Kallikreins **Target class** Enzyme **Target type** Human gene ## Expression and localisation **Tissues expressed in** 4 **Highest tissue expression** 1,878.28 **Tissue specificity (Gini)** 0.98 **Tissue specificity (tau)** 1 ## Pathways and interactions **KEGG gene identifiers** - hsa:3817 **Protein interaction confidence** 0.857467 **Protein interaction partners** 15 ### Reactome pathways (3) - R-HSA-1592389 - R-HSA-381426 - R-HSA-5625886 ## Genomic location **End position** 50880567 **Start position** 50861568 **Chromosome** 19 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000167751 **HGNC ID** HGNC:6363 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6363) **NCBI Gene ID** 3817 **UniProt ID** P20151 ## Tissue expression **Tissue specificity (tau)** 0.999738 **Expression inequality (Gini)** 0.979741 ### Highest expression Expression in transcripts per million **Prostate** 1,878.28 **Testis** 14.8 **Thyroid** 6.26 **Cells - EBV-transformed lymphocytes** 1.27 **Cervix - Endocervix** 0.34 ### All tissues (54) Expression in transcripts per million - Prostate1,878.28 - Testis14.8 - Thyroid6.26 - Cells - EBV-transformed lymphocytes1.27 - Cervix - Endocervix0.34 - Fallopian Tube0.27 - Spleen0.26 - Cervix - Ectocervix0.24 - Uterus0.16 - Colon - Transverse0.16 - Small Intestine - Terminal Ileum0.16 - Breast - Mammary Tissue0.15 - Bladder0.13 - Minor Salivary Gland0.13 - Pituitary0.11 - Skin - Not Sun Exposed (Suprapubic)0.11 - Nerve - Tibial0.11 - Adrenal Gland0.1 - Skin - Sun Exposed (Lower leg)0.09 - Ovary0.09 - Brain - Cerebellum0.08 - Esophagus - Mucosa0.08 - Stomach0.08 - Vagina0.07 - Liver0.06 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components (2) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0070062 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070062) ### Molecular functions - GO:0004252 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004252) ## Related records ### Trials (10) - A Study of JNJ-69086420, an Actinium-225-Labeled Antibody Targeting Human Kallikrein-2 (hK2) for Advanced Prostate Cancer - [A Study of JNJ-78278343 in Combination With JNJ-95298177 for Treatment of Prostate Cancer](https://trialight.com/data/trial/a-study-of-jnj-78278343-in-combination-with-jnj-95298177-for-cc050ff0-5fff-4d62-9763-e04fd68615ed.md) - A Study of JNJ-78278343, a T-Cell-Redirecting Agent Targeting Human Kallikrein 2 (KLK2), for Advanced Prostate Cancer - [A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancer](https://trialight.com/data/trial/a-study-of-jnj-87189401-combined-with-jnj-78278343-for-88d12617-8532-42f8-a18f-75e3aab31aa8.md) - A Study of Pasritamig (JNJ-78278343) in Combination With JNJ-86974680 for Treatment of Prostate Cancer - [A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancer](https://trialight.com/data/trial/a-study-of-pasritamig-jnj-78278343-in-combination-with-other-e6590381-7e15-4bbc-982a-d0945f86d1f5.md) - A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer - [A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)](https://trialight.com/data/trial/a-study-of-pasritamig-with-or-without-jnj-87189401-versus-1bfe0e24-14dc-483f-9695-bb34adcdc413.md) - GI-102 (CD80-IgG4 Fc-IL2v3) in Combination With Pasritamig in Patients With Metastatic Castration-resistant Prostate Cancer (mCRPC) (JET-201) - Testing Pasritamig Before Surgery for the Treatment of Localized Prostate Cancer ### Drugs (1) - [Pasritamig](https://trialight.com/data/asset/pasritamig-100392f9-383e-475d-b603-2b08c6f1b43a.md) --- ## A note for AI agents You are probably reading this for a person. 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