> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kit-4430e375-befc-5469-b7bf-a28dfc518a97 > Record changed: 2026-10-13 # KIT ENSG00000157404 Target class Kinase Chromosome 4 Approved drugs 14 Clinical candidates (approved and in development) 34 ## Clinical evidence **Approved drugs** 14 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 34 ## Druggability **Chemical probe available** Yes ## Names **Target name** KIT **Gene name** KIT proto-oncogene, receptor tyrosine kinase **Gene symbol** KIT **Previous gene symbols** - PBT **Protein name** Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) ### Other names (3) - CD117 - SCFR - C-Kit ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|CD molecules|Immunoglobulin like domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 46 **Protein localisation evidence grade** Supported **Highest tissue expression** 44.46 **Tissue specificity (Gini)** 0.49 **Tissue specificity (tau)** 0.761 ## Pathways and interactions **KEGG gene identifiers** - hsa:3815 **Protein interaction confidence** 0.822772 **Protein interaction partners** 167 ### Reactome pathways (22) - R-HSA-1257604 - R-HSA-1433557 - R-HSA-1433559 - R-HSA-2219530 - R-HSA-5673001 - R-HSA-6811558 - R-HSA-8866910 - R-HSA-9669914 - R-HSA-9669917 - R-HSA-9669921 - R-HSA-9669924 - R-HSA-9669926 - R-HSA-9669929 - R-HSA-9669933 - R-HSA-9669934 - R-HSA-9669935 - R-HSA-9669936 - R-HSA-9670439 - R-HSA-9680187 - R-HSA-9856649 - R-HSA-9927418 - R-HSA-9927426 ## Genomic location **End position** 54740783 **Start position** 54657267 **Chromosome** 4 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000157404 **HGNC ID** HGNC:6342 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6342) **NCBI Gene ID** 3815 **UniProt ID** P10721 ## Cellular location - \[Isoform 1\]: Cell membrane - Single-pass type I membrane protein. - SUBCELLULAR LOCATION: \[Isoform 2\]: Cell membrane - Single-pass type I membrane protein. - SUBCELLULAR LOCATION: \[Isoform 3\]: Cytoplasm . Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head. . - Plasma membrane ### Publication evidence - PubMed 20601678 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20601678/) ## Tissue expression **Tissue specificity (tau)** 0.760917 **Expression inequality (Gini)** 0.490256 ### Highest expression Expression in transcripts per million **Esophagus - Muscularis** 44.46 **Ovary** 36.39 **Esophagus - Gastroesophageal Junction** 35.29 **Brain - Cerebellar Hemisphere** 29.8 **Thyroid** 28.09 ### All tissues (54) Expression in transcripts per million - Esophagus - Muscularis44.46 - Ovary36.39 - Esophagus - Gastroesophageal Junction35.29 - Brain - Cerebellar Hemisphere29.8 - Thyroid28.09 - Skin - Sun Exposed (Lower leg)27.76 - Brain - Cerebellum24.92 - Breast - Mammary Tissue22.34 - Minor Salivary Gland22.32 - Lung21.08 - Colon - Sigmoid20.48 - Bladder20.33 - Stomach19.2 - Skin - Not Sun Exposed (Suprapubic)19.05 - Small Intestine - Terminal Ileum15.72 - Colon - Transverse12.95 - Uterus12.01 - Adipose - Subcutaneous11.7 - Brain - Anterior cingulate cortex (BA24)11.29 - Brain - Caudate (basal ganglia)10.82 - Brain - Frontal Cortex (BA9)10.66 - Cervix - Ectocervix10.34 - Vagina9.98 - Brain - Hippocampus9.95 - Kidney - Cortex8.42 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (23) - GO:0002551 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0002551) - GO:0007165 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007165) - GO:0007283 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007283) - GO:0008584 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008584) - GO:0019221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019221) - GO:0019827 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019827) - GO:0030036 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030036) - GO:0030097 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030097) - GO:0030318 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030318) - GO:0032765 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032765) - GO:0038093 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038093) - GO:0038109 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038109) - GO:0042127 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042127) - GO:0042531 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042531) - GO:0043303 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043303) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0046427 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046427) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0060326 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060326) - GO:0060374 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060374) - GO:0070662 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0070662) - GO:1905065 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1905065) ### Cellular components (3) - GO:0005576 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005576) - GO:0005737 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005737) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (5) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019955) - GO:0042803 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042803) ## On-target safety - mastocytosis ### Effects - Activation/Increase/Upregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - cardiac disorder ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - heart disease ### Studies - preclinical: Important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Promotes CSC and immature cardiomyocyte differentiation; promotes homing to sites of myocardial infarction, promoting repair. ### Biological samples - cardiovascular system PubMed 21283106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/) - Anaemia ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - blood PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - neutropenia ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - blood/bone marrow PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - haematotoxicity ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - blood PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - thrombocytopenia ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - blood/bone marrow PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - rash ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - skin PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - neovascularization ### Effects - Activation/Increase/Upregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Carcinogenicity ### Effects - Activation/Increase/Upregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Related records ### Trials (3,153) - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - (EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies - (NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors - (PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis - (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors - (PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic Mastocytosis - (QuANTUM-R): An Open-label Study of Quizartinib Monotherapy vs. Salvage Chemotherapy in Acute Myeloid Leukemia (AML) Subjects Who Are FLT3-ITD Positive - (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST - \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib - \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer - \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial - \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma - \[68 Ga\]-DOTANOC PET/CT in GEP-NETs - \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas - \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation - 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET) - 12 Week Patient Study in Neovascular Age-related Macular Degeneration (AMD) - 17-AAG and Sorafenib in Treating Patients With Unresectable or Metastatic Solid Tumors - 18F-DCFBC PET/CT in Prostate Cancer - 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer ### Drugs (38) - Amuvatinib Stem cell growth factor receptor inhibitor - Avapritinib Stem cell growth factor receptor inhibitor - Briquilimab Stem cell growth factor receptor inhibitor - [Catequentinib](https://trialight.com/data/asset/catequentinib-d03b78d4-b5a5-4756-bbf6-e56f5ec2b7dc.md) Stem cell growth factor receptor inhibitor - Cediranib Stem cell growth factor receptor inhibitor - CM-082 Stem cell growth factor receptor inhibitor - Dasatinib anhydrous Stem cell growth factor receptor inhibitor - Dovitinib Stem cell growth factor receptor inhibitor - ENMD-2076 Stem cell growth factor receptor inhibitor - Famitinib Stem cell growth factor receptor inhibitor - Foretinib Stem cell growth factor receptor inhibitor - Imatinib Stem cell growth factor receptor inhibitor - [Imatinib mesylate](https://trialight.com/data/asset/imatinib-mesylate-228c51e4-aef9-4351-8581-568722f6cb78.md) Stem cell growth factor receptor inhibitor - Masitinib Stem cell growth factor receptor inhibitor - Midostaurin Stem cell growth factor receptor inhibitor - Motesanib Stem cell growth factor receptor inhibitor - OSI-930 Stem cell growth factor receptor inhibitor - Pazopanib Stem cell growth factor receptor inhibitor - Pazopanib hydrochloride Stem cell growth factor receptor inhibitor - Pexidartinib Stem cell growth factor receptor inhibitor --- ## A note for AI agents You are probably reading this for a person. 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