> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/kif5b-9a9a85b6-97ac-5409-8ab2-cbc990e74a7d
> Record changed: 2026-10-13

# KIF5B

ENSG00000170759

Target class

Other cytosolic protein

Chromosome

10

Approved drugs

2

Clinical candidates (approved and in development)

2

## Clinical evidence

**Approved drugs**

2

**Clinical candidates (approved and in development)**

2

## Druggability

**Chemical probe available**

No

## Names

**Target name**

KIF5B

**Gene name**

Kinesin family member 5B

**Gene symbol**

KIF5B

**Previous gene symbols**

- KNS1

**Protein name**

Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC)

### Other names (2)

- KNS
- uKHC

## Classification

**Gene biotype**

Protein coding

**Gene family**

Kinesins

**Target class**

Other cytosolic protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

54

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

195.33

**Tissue specificity (Gini)**

0.25

**Tissue specificity (tau)**

0.65

## Pathways and interactions

**KEGG gene identifiers**

- hsa:3799

**Protein interaction confidence**

0.843643

**Protein interaction partners**

56

### Reactome pathways (6)

- R-HSA-2132295
- R-HSA-264876
- R-HSA-5625970
- R-HSA-6811434
- R-HSA-9725370
- R-HSA-983189

## Genomic location

**End position**

32056454

**Start position**

32009014

**Chromosome**

10

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000170759

**HGNC ID**

HGNC:6324

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6324)

**NCBI Gene ID**

3799

**UniProt ID**

P33176

## Cellular location

- Cytoplasm, cytoskeleton . Cytolytic granule membrane . Lysosome membrane
- Peripheral membrane protein
- Cytoplasmic side . Note=Uniformly distributed between soma and neurites in hippocampal neurons. .
- Centriolar satellite
- Cytosol
- End piece

### Publication evidence (2)

- PubMed 24088571  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24088571/)
- PubMed 22172677  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22172677/)

## Tissue expression

**Tissue specificity (tau)**

0.649742

**Expression inequality (Gini)**

0.250204

### Highest expression

Expression in transcripts per million

**Brain - Spinal cord (cervical c-1)**

195.33

**Artery - Tibial**

151.92

**Colon - Sigmoid**

132.44

**Esophagus - Muscularis**

125.18

**Cells - Cultured fibroblasts**

120.36

### All tissues (54)

Expression in transcripts per million

- Brain - Spinal cord (cervical c-1)195.33
- Artery - Tibial151.92
- Colon - Sigmoid132.44
- Esophagus - Muscularis125.18
- Cells - Cultured fibroblasts120.36
- Artery - Aorta113.91
- Brain - Substantia nigra105.77
- Artery - Coronary105.1
- Nerve - Tibial100.3
- Fallopian Tube99.78
- Uterus99.26
- Esophagus - Gastroesophageal Junction97.16
- Cervix - Ectocervix94.56
- Lung82.71
- Brain - Amygdala82.36
- Bladder81.22
- Cervix - Endocervix80.41
- Brain - Hippocampus71.39
- Prostate71.12
- Colon - Transverse70.88
- Brain - Hypothalamus70.16
- Adipose - Subcutaneous68.41
- Brain - Cortex68.4
- Vagina67.18
- Testis66.95

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (8)

- GO:0007018  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007018)
- GO:0032418  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032418)
- GO:0042267  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042267)
- GO:0042391  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042391)
- GO:0043268  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043268)
- GO:0047496  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0047496)
- GO:0051642  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051642)
- GO:1903078  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1903078)

### Cellular components (6)

- GO:0005765  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005765)
- GO:0005829  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829)
- GO:0005871  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005871)
- GO:0016020  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020)
- GO:0031982  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031982)
- GO:0101004  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0101004)

### Molecular functions (5)

- GO:0003777  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003777)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0008017  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008017)
- GO:0042802  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802)
- GO:0045296  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045296)

## Related records

### Trials (60)

- A Drug Drug Interaction (DDI) Study of Selpercatinib (LY3527723) and Rosuvastatin in Healthy Participants
- A Drug Drug Interaction (DDI) Study of Selpercatinib and Dabigatran in Healthy Participants
- A Real-world Study of Pralsetinib Combined With Leucogen in the Treatment of RET Fusion-positive NSCLC
- A Relative Bioavailability Study of Selpercatinib (LY3527723) in Healthy Participants
- A Retrospective and Prospective Real-world Study of Molecular Typing in the Treatment of Advanced Thyroid Cancer
- [A Study Comparing Two Formulations of Selpercatinib (LY3527723) in Healthy Participants](https://trialight.com/data/trial/a-study-comparing-two-formulations-of-selpercatinib-e64a5afd-5fd1-46a1-99a7-f6ffaa52b3aa.md)
- A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response
- A Study of Absorption, Metabolism, Excretion, and Absolute Bioavailability of Carbon-14-Labelled \[14C\] Selpercatinib (LY3527723) in Healthy Male Participants
- A Study of Effect of Food and a Proton Pump Inhibitor on Selpercatinib (LY3527723) in Healthy Participants
- A Study of Effect of Selpercatinib (LY3527723) in Participants With Normal and Impaired Renal Function
- A Study of Effect of Selpercatinib (LY3527723) on Corrected QT (QTc) Interval in Healthy Participants
- A Study of Effects of Itraconazole and Rifampin on Selpercatinib (LY3527723) in Healthy Participants
- A Study of Effects of Selpercatinib (LY3527723) on Midazolam in Healthy Participants
- A Study of Effects of Selpercatinib (LY3527723) on Repaglinide in Healthy Participants
- A Study of Effects of Selpercatinib in Hepatically Impaired Participants and Healthy Participants
- A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
- A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors
- A Study of Pralsetinib Versus Standard of Care (SOC) for Treatment of RET-Mutated Medullary Thyroid Cancer (MTC).
- A Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer (NSCLC)
- A Study of Selpercatinib (LOXO-292) in Participants With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)

### Drugs (2)

- Pralsetinib Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET inhibitor
- [Selpercatinib](https://trialight.com/data/asset/selpercatinib-b5343bcc-f751-4491-a1dd-3c8536f333da.md) Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET inhibitor

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