> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kdr-4ab08263-0477-533e-ac3f-96e20d343c4b > Record changed: 2026-10-13 # KDR ENSG00000128052 Target class Kinase Chromosome 4 Approved drugs 15 Clinical candidates (approved and in development) 75 ## Clinical evidence **Approved drugs** 15 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 75 ## Druggability **Chemical probe available** Yes ## Names **Target name** KDR **Gene name** Kinase insert domain receptor **Gene symbol** KDR **Protein name** Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309) ### Other names (4) - FLK1 - VEGFR - VEGFR2 - CD309 ## Classification **Gene biotype** Protein coding **Gene family** Receptor tyrosine kinases|CD molecules|V-set domain containing|I-set domain containing **Target class** Kinase **Target type** Human gene ## Expression and localisation **Tissues expressed in** 52 **Protein localisation evidence grade** Approved **Highest tissue expression** 80.12 **Tissue specificity (Gini)** 0.553 **Tissue specificity (tau)** 0.808 ## Pathways and interactions **KEGG gene identifiers** - hsa:3791 **Protein interaction confidence** 0.865438 **Protein interaction partners** 153 ### Reactome pathways (7) - R-HSA-194306 - R-HSA-195399 - R-HSA-216083 - R-HSA-4420097 - R-HSA-5218921 - R-HSA-9673768 - R-HSA-9856530 ## Genomic location **End position** 55125595 **Start position** 55078476 **Chromosome** 4 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000128052 **HGNC ID** HGNC:6307 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6307) **NCBI Gene ID** 3791 **UniProt ID** P35968 ## Cellular location - Cell junction . Endoplasmic reticulum . Cell membrane . Note=Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). . - SUBCELLULAR LOCATION: \[Isoform 1\]: Cell membrane - Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus. - SUBCELLULAR LOCATION: \[Isoform 2\]: Secreted . - SUBCELLULAR LOCATION: \[Isoform 3\]: Secreted. - Connecting piece - Cytosol - Mid piece - Nuclear membrane - Principal piece - Vesicles ### Publication evidence (2) - PubMed 23529610 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23529610/) - PubMed 25825981 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25825981/) ## Tissue expression **Tissue specificity (tau)** 0.80837 **Expression inequality (Gini)** 0.552748 ### Highest expression Expression in transcripts per million **Thyroid** 80.12 **Uterus** 78.64 **Adipose - Visceral (Omentum)** 73.72 **Lung** 50.77 **Breast - Mammary Tissue** 47.42 ### All tissues (54) Expression in transcripts per million - Thyroid80.12 - Uterus78.64 - Adipose - Visceral (Omentum)73.72 - Lung50.77 - Breast - Mammary Tissue47.42 - Adipose - Subcutaneous44.87 - Fallopian Tube40.76 - Nerve - Tibial36.29 - Cervix - Endocervix34.27 - Cervix - Ectocervix25.65 - Prostate23.22 - Esophagus - Muscularis21.34 - Pituitary20.56 - Artery - Coronary19.33 - Esophagus - Gastroesophageal Junction18.06 - Bladder18.06 - Artery - Tibial17.64 - Kidney - Cortex16.48 - Adrenal Gland16.06 - Vagina15.29 - Kidney - Medulla12.92 - Heart - Atrial Appendage11.76 - Small Intestine - Terminal Ileum11.26 - Stomach11.18 - Heart - Left Ventricle10.83 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (32) - GO:0001525 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001525) - GO:0001569 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001569) - GO:0001934 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001934) - GO:0001938 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001938) - GO:0007169 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007169) - GO:0008284 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008284) - GO:0008360 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008360) - GO:0010595 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010595) - GO:0010629 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010629) - GO:0016239 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016239) - GO:0018108 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0018108) - GO:0030335 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030335) - GO:0035924 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0035924) - GO:0036324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0036324) - GO:0038084 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038084) - GO:0043410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043410) - GO:0043536 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043536) - GO:0045766 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045766) - GO:0046777 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046777) - GO:0048010 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0048010) - GO:0050927 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050927) - GO:0051894 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051894) - GO:0051897 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051897) - GO:0051901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051901) - GO:0061042 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0061042) And 7 more, listed on the interactive page. ### Cellular components (7) - GO:0005768 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005768) - GO:0005783 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005783) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005829 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005829) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0031965 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031965) - GO:0045121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121) ### Molecular functions (10) - GO:0004713 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004713) - GO:0004714 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0004714) - GO:0005021 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005021) - GO:0005178 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005178) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0019838 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019838) - GO:0038085 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0038085) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0045296 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045296) - GO:0051879 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051879) ## On-target safety - decreased appetite ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CNS PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - myocardial hypoperfusion ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Increased, Developmental Defects ### Effects - Inhibition/Decrease/Downregulation ### Studies - cell-based Evidence source Source: [aopwiki.org](https://aopwiki.org/aops/43) - rash ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - skin PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - haemorrhage ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - aneurysm ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - heart disease ### Studies - preclinical: Highly important for the heart and vasculature based on findings in genetically modified or kinase-inhibitor-treated mice. Role of kinase in heart/vasculature: Crucial in angiogenesis and the heart’s response to pressure overload; antihypertensive effects ### Biological samples - cardiovascular system PubMed 21283106 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21283106/) - nausea ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - vomiting ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - GI PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - fatigue ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - proteinuria ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - renal PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) - Hypertension ### Effects - Inhibition/Decrease/Downregulation ### Studies - clinical ### Biological samples - CV PubMed 38773351 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38773351/) ## Off-target safety - regulation of catalytic activity ### Studies (2) - biochemical: NVS\_ENZ\_hVEGFR2, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hVEGFR2 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. - biochemical: NVS\_ENZ\_hVEGFR2, is one of one assay component(s) measured or calculated from the NVS\_ENZ\_hVEGFR2 assay. It is designed to make measurements of enzyme activity, a form of enzyme reporter, as detected with fluorescence intensity signals by Fluorescence and electrophoretic mobility shift technology. ### Biological samples - cell-free Evidence source Source: [www.epa.gov](https://www.epa.gov/chemical-research/exploring-toxcast-data-downloadable-data) ## Related records ### Trials (4,768) - - IKF/AIO-QUINTIS - Evaluating Fruquintinib in Combination With Tislelizumab in Microsatellite Stable / Proficient Mismatch Repair (MSS/pMMR) Metastatic Colorectal Cancer Without Active Liver Metastases - : A Phase Ib/II Study To Evaluate Fruquintinib Monotherapy Or Plus Sintilimab In Advanced Solid Tumors - "Thymalfasin Immunotherapy Study with Triple Regimen in Advanced MSS/pMMR Colorectal Cancer" - (Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors - (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST - \[18F\]FLT-PET as a Predictive Imaging Biomaker of Treatment Responses to Regorafenib - \[18F\]Fluciclatide-PET, Pazopanib and Paclitaxel in Ovarian Cancer - \[18F\]Fluoroestradiol-PET/CT Companion Imaging Study to the FORESEE Trial - \[18F\]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma - \[68 Ga\]-DOTANOC PET/CT in GEP-NETs - \[68Ga\]Ga-FAPI-46 in Staging of Head and Neck Carcinomas - \[68Ga\]Ga-PentixaFor PET/CT in Acute Myocardial Inflammation - 11C-methionine in Diagnostics and Management of Glioblastoma Multiforme Patients (GlioMET) - 12 Week Patient Study in Neovascular Age-related Macular Degeneration (AMD) - 17-AAG and Sorafenib in Treating Patients With Unresectable or Metastatic Solid Tumors - 18F-DCFBC PET/CT in Prostate Cancer - 18F-DCFPyL Positron Emission Tomography (PET)/Computed Tomography (CT) in Men With Prostate Cancer - 1st or 2nd Line MBC (Metastatic Breast Cancer) With Previous Avastin (Bevacizumab) Therapy - 1st-line Activity of Dovitinib and Correlation With Genetic Changes in RCC - 4SC-201 (Resminostat) and Sorafenib in Advanced Hepatocellular Carcinoma ### Drugs (83) - 4SC-203 Vascular endothelial growth factor receptor inhibitor - AEE-788 Vascular endothelial growth factor receptor 2 inhibitor - AG-13958 Vascular endothelial growth factor receptor inhibitor - Alacizumab pegol Vascular endothelial growth factor receptor 2 antagonist - Altiratinib Vascular endothelial growth factor receptor 2 inhibitor - Axitinib Vascular endothelial growth factor receptor inhibitor - BFH-772 Vascular endothelial growth factor receptor 2 inhibitor - BMS-690514 Vascular endothelial growth factor receptor inhibitor - BMS-794833 Vascular endothelial growth factor receptor 2 inhibitor - BMS-817378 Vascular endothelial growth factor receptor 2 inhibitor - Brivanib Vascular endothelial growth factor receptor inhibitor - Brivanib alaninate Vascular endothelial growth factor receptor inhibitor - [Cabozantinib](https://trialight.com/data/asset/cabozantinib-e69f9fa7-bbbc-4e52-b0df-6073598de2a7.md) Vascular endothelial growth factor receptor 2 inhibitor - Cabozantinib S-malate Vascular endothelial growth factor receptor 2 inhibitor - [Catequentinib](https://trialight.com/data/asset/catequentinib-d03b78d4-b5a5-4756-bbf6-e56f5ec2b7dc.md) Vascular endothelial growth factor receptor 2 inhibitor - Cediranib Vascular endothelial growth factor receptor inhibitor - [CEP-11981](https://trialight.com/data/asset/cep-11981-b221c5f0-2453-4f9c-b8b4-15a86c81e937.md) Vascular endothelial growth factor receptor inhibitor - CEP-5214 Vascular endothelial growth factor receptor inhibitor - CEP-7055 Vascular endothelial growth factor receptor inhibitor - CM-082 Vascular endothelial growth factor receptor 2 inhibitor --- ## A note for AI agents You are probably reading this for a person. 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