> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/kcnt1-f16ac1f1-af9a-573b-9e99-02d8d8d3f4f4
> Record changed: 2026-11-04

# KCNT1

ENSG00000107147

Target class

Unclassified protein

Chromosome

9

## Clinical evidence

**ClinGen gene-disease validity**

Definitive

## Druggability

**Chemical probe available**

No

## Names

**Target name**

KCNT1

**Gene name**

Potassium sodium-activated channel subfamily T member 1

**Gene symbol**

KCNT1

**Protein name**

Potassium channel subfamily T member 1 (KCa4.1) (KNa1.1) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.2)

### Other names (4)

- KCa4.1
- KIAA1422
- SLACK
- Slo2.2

## Classification

**Gene biotype**

Protein coding

**Gene family**

Potassium sodium-activated channel subfamily T 

**Target class**

Unclassified protein

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

18

**Protein localisation evidence grade**

Supported

**Highest tissue expression**

94.67

**Tissue specificity (Gini)**

0.829

**Tissue specificity (tau)**

0.943

## Pathways and interactions

**KEGG gene identifiers**

- hsa:57582

**Protein interaction confidence**

0.749167

**Protein interaction partners**

6

## Genomic location

**End position**

135795508

**Start position**

135702185

**Chromosome**

9

**Strand**

Forward

## Identifiers

**Ensembl gene ID**

ENSG00000107147

**HGNC ID**

HGNC:18865

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:18865)

**NCBI Gene ID**

57582

**UniProt ID**

Q5JUK3

## Cellular location

- Cell membrane
- Multi-pass membrane protein .
- Nucleoplasm
- Plasma membrane

### Publication evidence

- PubMed 37494189  
Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/37494189/)

## Tissue expression

**Tissue specificity (tau)**

0.942924

**Expression inequality (Gini)**

0.829031

### Highest expression

Expression in transcripts per million

**Brain - Cerebellum**

94.67

**Brain - Cerebellar Hemisphere**

80.08

**Brain - Cortex**

44.09

**Brain - Frontal Cortex (BA9)**

30.35

**Spleen**

20.19

### All tissues (54)

Expression in transcripts per million

- Brain - Cerebellum94.67
- Brain - Cerebellar Hemisphere80.08
- Brain - Cortex44.09
- Brain - Frontal Cortex (BA9)30.35
- Spleen20.19
- Brain - Anterior cingulate cortex (BA24)16.32
- Brain - Putamen (basal ganglia)13.56
- Brain - Caudate (basal ganglia)12.87
- Pituitary12.6
- Brain - Nucleus accumbens (basal ganglia)8.03
- Brain - Hypothalamus7.03
- Ovary7.01
- Muscle - Skeletal6.31
- Brain - Hippocampus5.45
- Brain - Amygdala5.23
- Testis2.54
- Brain - Substantia nigra1.34
- Brain - Spinal cord (cervical c-1)1.21
- Fallopian Tube0.8
- Artery - Coronary0.72
- Colon - Sigmoid0.67
- Heart - Left Ventricle0.65
- Lung0.63
- Adipose - Visceral (Omentum)0.58
- Uterus0.56

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes (2)

- GO:0051289  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051289)
- GO:0071805  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071805)

### Cellular components

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)

### Molecular functions (2)

- GO:0005228  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005228)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)

## Related records

### Trials (90)

- [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md)
- A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation
- A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants
- A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323.
- A Phase 1 Study Comparing AVP-786 With AVP-923
- A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects
- A Phase-1 Study to Assess the Pharmacokinetics, Safety and Tolerability of AVP-786 in Healthy Volunteers
- A Single and Multiple Ascending Dose Study of Niclosamide in Healthy Volunteers
- [A Single and Multiple Ascending Doses, Relative Bioavailability, Food Effect, and Drug-Drug Interaction Study of NX-5948 in Healthy Volunteers](https://trialight.com/data/trial/a-single-and-multiple-ascending-doses-relative-e765be29-f034-4382-84c2-075c49a7d226.md)
- A Study of Imlunestrant (LY3484356) in Female Healthy Participants
- A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis
- A Study of Niclosamide in Patients With Resectable Colon Cancer
- A Study of Staccato Loxapine (ADASUVE®) for Inhalation
- A Study to Assess the Effect of Voriconazole and Quinidine on the Pharmacokinetics of a Single Dose of Repotrectinib in Healthy Participants
- A Study to Evaluate the Effect of Genotype on LY2216684
- A Study To Evaluate The Efficacy And Safety Of a Novel Niclosamide Suspension Formulation For COVID-19
- A Study to Investigate the Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics in Fed and Fasted State and Pharmacokinetics of Balcinrenone When Dosed With a P-gp Inhibitor in Healthy Participants.
- A Study to Investigate the Pharmacokinetics of AZD2389 in Healthy Participants When Administered Alone and in Combination With Quinidine
- Abiraterone Acetate, Niclosamide, and Prednisone in Treating Patients With Hormone-Resistant Prostate Cancer
- ADASUVE 2-dose Thorough QT/QTc Study

### Drugs (6)

- Antrafenine
- Clofilium
- Clofilium phosphate
- Loxapine
- Niclosamide
- [Quinidine](https://trialight.com/data/asset/quinidine-87aba552-7096-4212-a930-5c3f4b7ce394.md)

---

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