> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kcnq2-415ec5cd-814f-5e15-9777-685a63a649db > Record changed: 2026-11-04 # KCNQ2 ENSG00000075043 Target class Ion channel Chromosome 20 Approved drugs 5 Clinical candidates (approved and in development) 8 ## Clinical evidence **Approved drugs** 5 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 8 ## Druggability **Chemical probe available** Yes ## Names **Target name** KCNQ2 **Gene name** Potassium voltage-gated channel subfamily Q member 2 **Gene symbol** KCNQ2 **Protein name** Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2) ### Other names (5) - Kv7.2 - ENB1 - BFNC - KCNA11 - HNSPC ### Previous gene symbols (2) - EBN - EBN1 ## Classification **Gene biotype** Protein coding **Gene family** Potassium voltage-gated channels **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 15 **Protein localisation evidence grade** Approved **Highest tissue expression** 165.96 **Tissue specificity (Gini)** 0.852 **Tissue specificity (tau)** 0.936 ## Pathways and interactions **KEGG gene identifiers** - hsa:3785 **Protein interaction confidence** 0.858341 **Protein interaction partners** 44 ### Reactome pathways (2) - R-HSA-1296072 - R-HSA-445095 ## Genomic location **End position** 63472677 **Start position** 63400208 **Chromosome** 20 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000075043 **HGNC ID** HGNC:6296 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6296) **NCBI Gene ID** 3785 **UniProt ID** O43526 ## Cellular location - Cell membrane - Multi-pass membrane protein . - Endoplasmic reticulum ### Publication evidence (2) - PubMed 10788442 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10788442/) - PubMed 9836639 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9836639/) ## Tissue expression **Tissue specificity (tau)** 0.936044 **Expression inequality (Gini)** 0.852162 ### Highest expression Expression in transcripts per million **Brain - Cerebellum** 165.96 **Brain - Cerebellar Hemisphere** 146.51 **Brain - Cortex** 68.13 **Brain - Frontal Cortex (BA9)** 64.13 **Brain - Anterior cingulate cortex (BA24)** 50.14 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellum165.96 - Brain - Cerebellar Hemisphere146.51 - Brain - Cortex68.13 - Brain - Frontal Cortex (BA9)64.13 - Brain - Anterior cingulate cortex (BA24)50.14 - Brain - Nucleus accumbens (basal ganglia)43.36 - Brain - Caudate (basal ganglia)36.76 - Brain - Hippocampus35.04 - Brain - Amygdala34.71 - Brain - Putamen (basal ganglia)26.18 - Brain - Hypothalamus23.11 - Pituitary14 - Brain - Substantia nigra8.11 - Testis6.46 - Brain - Spinal cord (cervical c-1)3.54 - Colon - Sigmoid0.48 - Pancreas0.18 - Colon - Transverse0.17 - Cells - EBV-transformed lymphocytes0.16 - Prostate0.12 - Esophagus - Muscularis0.11 - Esophagus - Gastroesophageal Junction0.11 - Small Intestine - Terminal Ileum0.1 - Adrenal Gland0.08 - Kidney - Medulla0.08 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (3) - GO:0007268 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007268) - GO:0007399 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007399) - GO:0071805 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071805) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0008076 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008076) ### Molecular functions (5) - GO:0005249 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005249) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0005516 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005516) - GO:0022843 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0022843) - GO:0030506 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030506) ## Related records ### Trials (176) - 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenia (CM) - 4-aminopyridine for Skin Wound Healing - 4-Aminopyridine in Episodic Ataxia Type 2 - 4-Aminopyridine to Treat Skin Burns - 4-aminopyridine Treatment for Nerve Injury - 4-aminopyridine Treatment for Nerve Injury From Radical Retro-Pubic Prostatectomy - 4-Aminopyridine, Atenolol, or Placebo in Patients With Vestibular Migraine - 4-AP Peripheral Nerve Crossover Trial - 4AP for Carpal Tunnel Syndrome (CTS) - A Long-term, Safety, Tolerability, and Efficacy Study of Retigabine Immediate-release (IR) in Asian Adults With Partial Onset Seizures - A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) - A Phase 2b Study of Dalfampridine 10mg Extended Release Tablet in Subjects With Chronic Deficits After Ischemic Stroke - A Phase 3 Study of Amifampridine Phosphate in Patients With Lambert Eaton Myasthenic Syndrome (LEMS) - A Placebo Controlled Trial of Dalfampridine ER for Ambulatory Activity in People With Multiple Sclerosis - A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression) - A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder - A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3) - A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures - A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3) - A Randomized Trial to Evaluate Ampyra for Gait Impairment in Parkinson's Disease ### Drugs (17) - Amifampridine Voltage-gated potassium channel blocker - Amifampridine phosphate Voltage-gated potassium channel blocker - [Azetukalner](https://trialight.com/data/asset/azetukalner-bdf1d84d-c0a0-49bc-a75e-2afa9bab990b.md) - Dalfampridine Voltage-gated potassium channel blocker - Dronedarone - Ezogabine KCNQ (Kv7) potassium channel opener - Flindokalner Voltage-gated potassium channel subunit Kv7.2 activator - Flupirtine - Guanidine Voltage-gated potassium channel blocker - Guanidine hydrochloride Voltage-gated potassium channel blocker - Linopirdine - Nerispirdine Voltage-gated potassium channel blocker - Pyrithione zinc - Tedisamil Voltage-gated potassium channel blocker - Tedisamil sesquifumarate Voltage-gated potassium channel blocker - Tetrylammonium - Tetrylammonium bromide --- ## A note for AI agents You are probably reading this for a person. 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