> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kcnma1-2d12d581-237c-53e2-a99f-113b7329be4b > Record changed: 2026-11-04 # KCNMA1 ENSG00000156113 Target class Ion channel Chromosome 10 Approved drugs 0 Clinical candidates (approved and in development) 3 ## Clinical evidence **Approved drugs** 0 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 3 ## Druggability **Chemical probe available** No ## Names **Target name** KCNMA1 **Gene name** Potassium calcium-activated channel subfamily M alpha 1 **Gene symbol** KCNMA1 **Previous gene symbols** - SLO **Protein name** Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo) ### Other names (2) - KCa1.1 - mSLO1 ## Classification **Gene biotype** Protein coding **Gene family** Potassium calcium-activated channels **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 44 **Highest tissue expression** 43.8 **Tissue specificity (Gini)** 0.604 **Tissue specificity (tau)** 0.841 ## Pathways and interactions **KEGG gene identifiers** - hsa:3778 **Protein interaction confidence** 0.887077 **Protein interaction partners** 26 ### Reactome pathways (4) - R-HSA-1296052 - R-HSA-418457 - R-HSA-9662360 - R-HSA-9667769 ## Genomic location **End position** 77638369 **Start position** 76869601 **Chromosome** 10 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000156113 **HGNC ID** HGNC:6284 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6284) **NCBI Gene ID** 3778 **UniProt ID** Q12791 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (2) - PubMed 20693285 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20693285/) - PubMed 22399288 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22399288/) ## Tissue expression **Tissue specificity (tau)** 0.840652 **Expression inequality (Gini)** 0.603938 ### Highest expression Expression in transcripts per million **Uterus** 43.8 **Colon - Sigmoid** 36.37 **Artery - Tibial** 30.29 **Esophagus - Muscularis** 29.53 **Esophagus - Gastroesophageal Junction** 29.29 ### All tissues (54) Expression in transcripts per million - Uterus43.8 - Colon - Sigmoid36.37 - Artery - Tibial30.29 - Esophagus - Muscularis29.53 - Esophagus - Gastroesophageal Junction29.29 - Artery - Aorta27.01 - Cervix - Endocervix16.97 - Brain - Frontal Cortex (BA9)14.71 - Artery - Coronary13.68 - Brain - Cortex11.91 - Colon - Transverse11.8 - Fallopian Tube11.59 - Bladder11.24 - Cervix - Ectocervix10.5 - Brain - Anterior cingulate cortex (BA24)9.63 - Prostate7.74 - Brain - Nucleus accumbens (basal ganglia)7.24 - Muscle - Skeletal6.02 - Brain - Caudate (basal ganglia)5.75 - Brain - Cerebellum5.49 - Brain - Amygdala5.15 - Vagina4.99 - Brain - Hypothalamus4.83 - Brain - Hippocampus4.65 - Pituitary4.34 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (11) - GO:0001666 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0001666) - GO:0006813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006813) - GO:0006970 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006970) - GO:0030007 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030007) - GO:0034465 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034465) - GO:0042391 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042391) - GO:0043065 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0043065) - GO:0045794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045794) - GO:0051592 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051592) - GO:0060073 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060073) - GO:0060083 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060083) ### Cellular components (5) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005901) - GO:0008076 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008076) - GO:0016020 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016020) - GO:0016324 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0016324) ### Molecular functions (5) - GO:0003779 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0003779) - GO:0005249 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005249) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015269 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015269) - GO:0060072 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060072) ## Related records ### Trials (427) - 3-year Study of Menostar Versus Evista to Prevent Osteoporosis in Post-menopausal Women - A Clinical Study to Evaluate CAD-1883 in Essential Tremor - A Clinical Study to Evaluate the Effects of Estrogen in Healthy Postmenopausal Women - A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain - A Comparison of Estradiol Vaginal Cream to Estrace® Cream in 350 Postmenopausal Females With Atrophic Vaginitis - A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients With AIDS - A Definitive Estrogen Patch Study (ADEPT) - A Dose-Finding Study to Evaluate Ovarian Function and Vaginal Bleeding in Next Generation Rings (P06109/MK-8175A/MK-8342B-012) - A Pharmacokinetic Evaluation of Bioidentical Compounded Estrogen Cream and Natural Progesterone - A Phase 3 Study to Confirm the Efficacy and Safety of Linzagolix to Treat Endometriosis-associated Pain - A Protocol for the Role of Fractional CO2 Laser in Consolidation Treatment of Recurrent Vulvovaginal Candidiasis - A Randomized Controlled Trial of Oral Naproxen and Transdermal Estradiol for Bleeding in LNG-IUC - A Randomized, Single Center Pilot Study Comparing Hyaluronic Acid to Vaginal Estrogen for Treatment of Genitourinary Syndrome of Menopause - A Safety and Efficacy Study of Estradiol Vaginal Capsule in Postmenopausal Women With Vulvovaginal Atrophy - A Safety and Efficacy Study of the Combination Estradiol and Progesterone to Treat Vasomotor Symptoms - A Study Comparing Different Treatment Approaches for the Initiation of Puberty in Girls With Turner Syndrome Using a TRIFECTA-DARED Approach for Rare Diseases - A Study Comparing Estradiol Vaginal Cream to Estrace® Cream in Females With Atrophic Vaginitis - A Study of MK-6913 for the Treatment of Hot Flashes in Postmenopausal Women (6913-004) - A Study of Soticlestat With Itraconazole and Mefenamic Acid in Healthy Adults - A Study of the Effect of Estrogen on Estrogen Receptor Biomarkers in Healthy Postmenopausal Women (0000-094)(COMPLETED) ### Drugs (11) - Andolast Calcium-activated potassium channel subunit alpha-1 activator - BMS-223131 Calcium-activated potassium channel subunit alpha-1 activator - Chlorzoxazone - Clotrimazole - [Estradiol](https://trialight.com/data/asset/estradiol-0b121e99-a1da-433f-be00-a9b7e9d5f80c.md) - Fanchinin - Flindokalner Calcium-activated potassium channel subunit alpha-1 opener - Mefenamic acid - Rimtuzalcap - Tetrylammonium - Tetrylammonium bromide --- ## A note for AI agents You are probably reading this for a person. 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