> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kcnk7-23e3e525-97b1-5589-a9cd-2b098576b70a > Record changed: 2026-11-04 # KCNK7 ENSG00000173338 Chromosome 11 ## Druggability **Chemical probe available** No ## Names **Other names** - K2p7.1 **Target name** KCNK7 **Gene name** Potassium two pore domain channel subfamily K member 7 **Gene symbol** KCNK7 **Protein name** Potassium channel subfamily K member 7 ## Classification **Gene biotype** Protein coding **Gene family** Potassium two pore domain channel subfamily K **Target type** Human gene ## Expression and localisation **Tissues expressed in** 36 **Protein localisation evidence grade** Approved **Highest tissue expression** 83.66 **Tissue specificity (Gini)** 0.746 **Tissue specificity (tau)** 0.96 ## Pathways and interactions **KEGG gene identifiers** - hsa:10089 **Protein interaction confidence** 0.80725 **Protein interaction partners** 4 ### Reactome pathways (2) - R-HSA-1299308 - R-HSA-5576886 ## Genomic location **End position** 65595996 **Start position** 65592836 **Chromosome** 11 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000173338 **HGNC ID** HGNC:6282 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6282) **NCBI Gene ID** 10089 **UniProt ID** Q9Y2U2 ## Cellular location - Membrane - Multi-pass membrane protein . - Plasma membrane ## Tissue expression **Tissue specificity (tau)** 0.959632 **Expression inequality (Gini)** 0.746227 ### Highest expression Expression in transcripts per million **Skin - Not Sun Exposed (Suprapubic)** 83.66 **Skin - Sun Exposed (Lower leg)** 79.96 **Esophagus - Mucosa** 12.87 **Vagina** 7.42 **Brain - Cerebellar Hemisphere** 5.01 ### All tissues (54) Expression in transcripts per million - Skin - Not Sun Exposed (Suprapubic)83.66 - Skin - Sun Exposed (Lower leg)79.96 - Esophagus - Mucosa12.87 - Vagina7.42 - Brain - Cerebellar Hemisphere5.01 - Brain - Cerebellum4.9 - Nerve - Tibial3.62 - Whole Blood3.33 - Fallopian Tube2.71 - Bladder2.54 - Cervix - Ectocervix2.46 - Spleen2.4 - Colon - Sigmoid2.37 - Uterus2.36 - Esophagus - Gastroesophageal Junction2.18 - Lung2.06 - Cervix - Endocervix1.99 - Esophagus - Muscularis1.99 - Artery - Coronary1.96 - Ovary1.92 - Brain - Frontal Cortex (BA9)1.91 - Brain - Cortex1.9 - Artery - Tibial1.89 - Artery - Aorta1.82 - Brain - Spinal cord (cervical c-1)1.74 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0006813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006813) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions - GO:0005267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005267) ## Related records ### Trials (559) - "Dapagliflozin vs Dapagliflozin-Finerenone for Albuminuria in CKD With Type 2 Diabetes" - "Exploring the Potential Benefits of Using Dapagliflozin in Cirrhotic Chronic Liver Disease Patients- A Randomized Controlled Trial" - A 24-week Open-Label, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects withType 2 Diabetes Who Have Glycemic Control on Metformin - A 52-week International, Multicenter Trial With a Long -Term Extension to Evaluate Saxagliptin With Dapagliflozin in Combination With Metformin Compared to Glimepiride in Combination With Metformin in Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Alone - A Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease - A Clinical Study to Investigate the Effects of Dapagliflozin on Heart Work, Heart Nutrient Uptake, and Heart Muscle Efficiency in Type 2 Diabetes Patients - A Clinical Trial to Evaluate the Bone Metabolism and the Blood Sugar of Evogliptin and Dapagliflozin - A Clinical Trial to Evaluate the Safety and the Pharmacokinetic Interaction of Telmisartan and Dapagliflozin. - A Comparison of Effectiveness, Safety, and Cost-effectiveness of Dapagliflozin and Empagliflozin in Patients With Type 2 Diabetes Mellitus and High Body Mass Index (BMI) - A Comparison of Postprandial Glucose After a MMTT, and the Metabolic Effects of Insulin Withdrawal in a Crossover Study in Subjects With Type 1 Diabetes - A Multi-Center, Randomized, Double-Blind, Phase III Trial to Evaluate the Safety and Efficacy of Saxagliptin Co-administered With Dapagliflozin Compared to Saxagliptin or Dapagliflozin All Given as add-on Therapy to Metformin in Subject With Type 2 Diabetes - A Pharmacokinetic Study of SID1903 (FDC of Dapagliflozin and Sitagliptin) in Healthy Adult Volunteers - A Phase 2b Diabetic Kidney Disease Study - A Phase 3 Study to Evaluate Efficacy and Safety of HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus - A Phase I PK Study of Balcinrenone/Dapagliflozin in Healthy Chinese Participants - A Phase Ib Study of AZD5462 on Top of Dapagliflozin in Participants With Heart Failure and Moderate Renal Impairment - A Phase IIA Study of BMS-512148 to Assess Safety, Exposure, and Biological Effects in Stable Type 2 Diabetic Subjects - A Phase IIb Study to Evaluate the Effect of Dapagliflozin in Combination With Baxdrostat Compared With Baxdrostat on Albuminuria in Participants With Chronic Kidney Disease and High Blood Pressure. - A Phase IIb Study to Evaluate the Safety of Zibotentan/Dapagliflozin in Participants With Cirrhosis-ZEAL-UNLOCK - [A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure](https://trialight.com/data/trial/a-phase-iii-renal-outcomes-and-cardiovascular-mortality-c5f29ecd-a0cc-4264-97cc-549e6ce6e4bb.md) ### Drugs (1) - [Dapagliflozin](https://trialight.com/data/asset/dapagliflozin-894f296e-52de-4036-ac69-f399eea07356.md) --- ## A note for AI agents You are probably reading this for a person. 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