> Trialight public data. Index of pages: https://trialight.com/llms.txt
> Web page: https://trialight.com/data/target/kcnk5-3fd683fa-6105-5a51-a325-de4e6d0ed6ba
> Record changed: 2026-11-04

# KCNK5

ENSG00000164626

Target class

Ion channel

Chromosome

6

## Druggability

**Chemical probe available**

No

## Names

**Target name**

KCNK5

**Gene name**

Potassium two pore domain channel subfamily K member 5

**Gene symbol**

KCNK5

**Protein name**

Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2)

### Other names (3)

- K2p5.1
- TASK-2
- TASK2

## Classification

**Gene biotype**

Protein coding

**Gene family**

Potassium two pore domain channel subfamily K

**Target class**

Ion channel

**Target type**

Human gene

## Expression and localisation

**Tissues expressed in**

37

**Protein localisation evidence grade**

Approved

**Highest tissue expression**

46.33

**Tissue specificity (Gini)**

0.631

**Tissue specificity (tau)**

0.831

## Pathways and interactions

**KEGG gene identifiers**

- hsa:8645

**Reactome pathways**

- R-HSA-5576886

**Protein interaction confidence**

0.8605

**Protein interaction partners**

8

## Genomic location

**End position**

39229559

**Start position**

39188128

**Chromosome**

6

**Strand**

Reverse

## Identifiers

**Ensembl gene ID**

ENSG00000164626

**HGNC ID**

HGNC:6280

Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6280)

**NCBI Gene ID**

8645

**UniProt ID**

O95279

## Cellular location

- Membrane
- Multi-pass membrane protein .
- Nucleoplasm

## Tissue expression

**Tissue specificity (tau)**

0.830983

**Expression inequality (Gini)**

0.631491

### Highest expression

Expression in transcripts per million

**Skin - Sun Exposed (Lower leg)**

46.33

**Minor Salivary Gland**

39.42

**Nerve - Tibial**

34.32

**Kidney - Cortex**

33.47

**Small Intestine - Terminal Ileum**

28.49

### All tissues (54)

Expression in transcripts per million

- Skin - Sun Exposed (Lower leg)46.33
- Minor Salivary Gland39.42
- Nerve - Tibial34.32
- Kidney - Cortex33.47
- Small Intestine - Terminal Ileum28.49
- Skin - Not Sun Exposed (Suprapubic)26.25
- Thyroid21.82
- Colon - Transverse18.74
- Colon - Sigmoid15.56
- Vagina13.86
- Pancreas13.75
- Kidney - Medulla13.31
- Stomach11.86
- Liver11.74
- Ovary11.43
- Cervix - Ectocervix11.07
- Esophagus - Muscularis10.6
- Lung10.34
- Esophagus - Gastroesophageal Junction10.32
- Cervix - Endocervix8.93
- Esophagus - Mucosa8.66
- Breast - Mammary Tissue8.16
- Adipose - Visceral (Omentum)6.29
- Prostate6.21
- Adipose - Subcutaneous5.81

And 29 more, listed on the interactive page.

## Biological functions

### Biological processes

- GO:0006813  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006813)

### Cellular components

- GO:0005886  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886)

### Molecular functions (4)

- GO:0005267  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005267)
- GO:0005515  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)
- GO:0015271  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015271)
- GO:0046982  
Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982)

## Related records

### Trials (40)

- [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md)
- A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation
- A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants
- A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323.
- A Phase 1 Study Comparing AVP-786 With AVP-923
- A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects
- A Phase-1 Study to Assess the Pharmacokinetics, Safety and Tolerability of AVP-786 in Healthy Volunteers
- [A Single and Multiple Ascending Doses, Relative Bioavailability, Food Effect, and Drug-Drug Interaction Study of NX-5948 in Healthy Volunteers](https://trialight.com/data/trial/a-single-and-multiple-ascending-doses-relative-e765be29-f034-4382-84c2-075c49a7d226.md)
- A Study of Imlunestrant (LY3484356) in Female Healthy Participants
- A Study to Assess the Effect of Voriconazole and Quinidine on the Pharmacokinetics of a Single Dose of Repotrectinib in Healthy Participants
- A Study to Evaluate the Effect of Genotype on LY2216684
- A Study to Investigate the Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics in Fed and Fasted State and Pharmacokinetics of Balcinrenone When Dosed With a P-gp Inhibitor in Healthy Participants.
- A Study to Investigate the Pharmacokinetics of AZD2389 in Healthy Participants When Administered Alone and in Combination With Quinidine
- Assessment of the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide \[d6-DM\]/Quinidine Sulfate \[Q\]) for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
- Assessment of the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
- Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)
- Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE)
- Drug Interaction Study Between AVP-923 and Itraconazole and Between AVP-786 and Itraconazole in Healthy Adult Subejcts
- Drug-Drug Interaction Study Between EDP-235, Itraconazole, Carbamazepine and Quinidine in Healthy Subjects.
- Drug-drug Interaction Study Between EDP-305, Fluconazole and Quinidine in Healthy Volunteers

### Drugs (2)

- Halothane
- [Quinidine](https://trialight.com/data/asset/quinidine-87aba552-7096-4212-a930-5c3f4b7ce394.md)

---

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