KCNK5
ENSG00000164626
Target class
Ion channel
Chromosome
6
- Chemical probe available
- No
- Target name
- KCNK5
- Gene name
- Potassium two pore domain channel subfamily K member 5
- Gene symbol
- KCNK5
- Protein name
- Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2)
- K2p5.1
- TASK-2
- TASK2
- Gene biotype
- Protein coding
- Gene family
- Potassium two pore domain channel subfamily K
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 37
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 46.33
- Tissue specificity (Gini)
- 0.631
- Tissue specificity (tau)
- 0.831
- KEGG gene identifiers
- hsa:8645
- Reactome pathways
- R-HSA-5576886
- Protein interaction confidence
- 0.8605
- Protein interaction partners
- 8
- End position
- 39229559
- Start position
- 39188128
- Chromosome
- 6
- Strand
- Reverse
- Membrane
- Multi-pass membrane protein .
- Nucleoplasm
- Tissue specificity (tau)
- 0.830983
- Expression inequality (Gini)
- 0.631491
Expression in transcripts per million
- Skin - Sun Exposed (Lower leg)
- 46.33
- Minor Salivary Gland
- 39.42
- Nerve - Tibial
- 34.32
- Kidney - Cortex
- 33.47
- Small Intestine - Terminal Ileum
- 28.49
Expression in transcripts per million
- Skin - Sun Exposed (Lower leg)46.33
- Minor Salivary Gland39.42
- Nerve - Tibial34.32
- Kidney - Cortex33.47
- Small Intestine - Terminal Ileum28.49
- Skin - Not Sun Exposed (Suprapubic)26.25
- Thyroid21.82
- Colon - Transverse18.74
- Colon - Sigmoid15.56
- Vagina13.86
- Pancreas13.75
- Kidney - Medulla13.31
- Stomach11.86
- Liver11.74
- Ovary11.43
- Cervix - Ectocervix11.07
- Esophagus - Muscularis10.6
- Lung10.34
- Esophagus - Gastroesophageal Junction10.32
- Cervix - Endocervix8.93
- Esophagus - Mucosa8.66
- Breast - Mammary Tissue8.16
- Adipose - Visceral (Omentum)6.29
- Prostate6.21
- Adipose - Subcutaneous5.81
And 29 more, listed on the interactive page.
Biological processes
- GO:0006813
Cellular components
- GO:0005886
- GO:0005267
- GO:0005515
- GO:0015271
- GO:0046982
Related records
Trials (40)
- A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)
- A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation
- A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants
- A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323.
- A Phase 1 Study Comparing AVP-786 With AVP-923
- A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects
- A Phase-1 Study to Assess the Pharmacokinetics, Safety and Tolerability of AVP-786 in Healthy Volunteers
- A Single and Multiple Ascending Doses, Relative Bioavailability, Food Effect, and Drug-Drug Interaction Study of NX-5948 in Healthy Volunteers
- A Study of Imlunestrant (LY3484356) in Female Healthy Participants
- A Study to Assess the Effect of Voriconazole and Quinidine on the Pharmacokinetics of a Single Dose of Repotrectinib in Healthy Participants
- A Study to Evaluate the Effect of Genotype on LY2216684
- A Study to Investigate the Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics in Fed and Fasted State and Pharmacokinetics of Balcinrenone When Dosed With a P-gp Inhibitor in Healthy Participants.
- A Study to Investigate the Pharmacokinetics of AZD2389 in Healthy Participants When Administered Alone and in Combination With Quinidine
- Assessment of the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]) for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
- Assessment of the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type
- Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)
- Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE)
- Drug Interaction Study Between AVP-923 and Itraconazole and Between AVP-786 and Itraconazole in Healthy Adult Subejcts
- Drug-Drug Interaction Study Between EDP-235, Itraconazole, Carbamazepine and Quinidine in Healthy Subjects.
- Drug-drug Interaction Study Between EDP-305, Fluconazole and Quinidine in Healthy Volunteers
Drugs (2)
- Halothane
- Quinidine