> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kcnk16-2e4a5663-20ef-55a4-a55f-a02d9b92e04f > Record changed: 2026-11-04 # KCNK16 ENSG00000095981 Chromosome 6 ## Druggability **Chemical probe available** No ## Names **Target name** KCNK16 **Gene name** Potassium two pore domain channel subfamily K member 16 **Gene symbol** KCNK16 **Protein name** Potassium channel subfamily K member 16 (2P domain potassium channel Talk-1) (TWIK-related alkaline pH-activated K(+) channel 1) (TALK-1) ### Other names (3) - K2p16.1 - TALK-1 - TALK1 ## Classification **Gene biotype** Protein coding **Gene family** Potassium two pore domain channel subfamily K **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Highest tissue expression** 2.51 **Tissue specificity (Gini)** 0.948 **Tissue specificity (tau)** 0.993 ## Pathways and interactions **KEGG gene identifiers** - hsa:83795 **Protein interaction confidence** 0.74 **Protein interaction partners** 2 ### Reactome pathways (2) - R-HSA-1299361 - R-HSA-5576886 ## Genomic location **End position** 39322968 **Start position** 39314698 **Chromosome** 6 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000095981 **HGNC ID** HGNC:14464 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:14464) **NCBI Gene ID** 83795 **UniProt ID** Q96T55 ## Cellular location - \[Isoform a\]: Endoplasmic reticulum membrane - Multi-pass membrane protein . Cell membrane - Multi-pass membrane protein . - SUBCELLULAR LOCATION: \[Isoform b\]: Endoplasmic reticulum membrane - Multi-pass membrane protein . Mitochondrion inner membrane - Multi-pass membrane protein . ### Publication evidence (3) - PubMed 28928238 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28928238/) - PubMed 26239056 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/26239056/) - PubMed 38206814 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/38206814/) ## Tissue expression **Tissue specificity (tau)** 0.993009 **Expression inequality (Gini)** 0.948428 ### Highest expression Expression in transcripts per million **Pancreas** 2.51 **Stomach** 0.27 **Thyroid** 0.22 **Testis** 0.16 **Artery - Aorta** 0.07 ### All tissues (54) Expression in transcripts per million - Pancreas2.51 - Stomach0.27 - Thyroid0.22 - Testis0.16 - Artery - Aorta0.07 - Lung0.05 - Pituitary0.03 - Brain - Spinal cord (cervical c-1)0.03 - Artery - Coronary0.03 - Small Intestine - Terminal Ileum0.02 - Brain - Substantia nigra0.02 - Brain - Hippocampus0.02 - Brain - Putamen (basal ganglia)0.01 - Muscle - Skeletal0 - Cells - Cultured fibroblasts0 - Adrenal Gland0 - Whole Blood0 - Kidney - Medulla0 - Artery - Tibial0 - Uterus0 - Ovary0 - Cells - EBV-transformed lymphocytes0 - Brain - Cortex0 - Skin - Sun Exposed (Lower leg)0 - Brain - Anterior cingulate cortex (BA24)0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (4) - GO:0006813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006813) - GO:0032469 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0032469) - GO:0051279 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051279) - GO:0098900 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098900) ### Cellular components (2) - GO:0005789 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005789) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (5) - GO:0005267 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005267) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015271 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015271) - GO:0042802 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042802) - GO:0046982 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046982) ## Related records ### Trials (123) - [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md) - A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation - A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants - A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323. - A Phase 1 Study Comparing AVP-786 With AVP-923 - A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects - A Phase-1 Study to Assess the Pharmacokinetics, Safety and Tolerability of AVP-786 in Healthy Volunteers - A Pooled Analysis of Long-Term Outcomes After Inhaled Isoflurane Via the Sedaconda ACD-S Compared to Intravenous Propofol - [A Single and Multiple Ascending Doses, Relative Bioavailability, Food Effect, and Drug-Drug Interaction Study of NX-5948 in Healthy Volunteers](https://trialight.com/data/trial/a-single-and-multiple-ascending-doses-relative-e765be29-f034-4382-84c2-075c49a7d226.md) - A Study of Imlunestrant (LY3484356) in Female Healthy Participants - A Study to Assess the Effect of Voriconazole and Quinidine on the Pharmacokinetics of a Single Dose of Repotrectinib in Healthy Participants - A Study to Evaluate the Effect of Genotype on LY2216684 - A Study to Investigate the Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics in Fed and Fasted State and Pharmacokinetics of Balcinrenone When Dosed With a P-gp Inhibitor in Healthy Participants. - A Study to Investigate the Pharmacokinetics of AZD2389 in Healthy Participants When Administered Alone and in Combination With Quinidine - AnaConDa Long Term Sedation Study - Assessment of the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide \[d6-DM\]/Quinidine Sulfate \[Q\]) for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type - Assessment of the Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type - Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) - Automated Control of End-tidal Volatile Anesthetic Concentration - Cardiac Arrest in Seattle: Conventional Versus Amiodarone Drug Evaluation (CASCADE) ### Drugs (3) - Chloroform - Isoflurane - [Quinidine](https://trialight.com/data/asset/quinidine-87aba552-7096-4212-a930-5c3f4b7ce394.md) --- ## A note for AI agents You are probably reading this for a person. 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