> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kcnj11-0c4c8434-214d-5b32-815c-56501b745a8a > Record changed: 2026-10-13 # KCNJ11 ENSG00000187486 Target class Ion channel Chromosome 11 Approved drugs 13 Clinical candidates (approved and in development) 18 ## Clinical evidence **Approved drugs** 13 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 18 ## Druggability **Chemical probe available** Yes ## Names **Target name** KCNJ11 **Gene name** Potassium inwardly rectifying channel subfamily J member 11 **Gene symbol** KCNJ11 **Protein name** ATP-sensitive inward rectifier potassium channel 11 (IKATP) (Inward rectifier K(+) channel Kir6.2) (Potassium channel, inwardly rectifying subfamily J member 11) ### Other names (2) - Kir6.2 - BIR ## Classification **Gene biotype** Protein coding **Gene family** Potassium inwardly rectifying channel subfamily J **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 40 **Highest tissue expression** 87.08 **Tissue specificity (Gini)** 0.696 **Tissue specificity (tau)** 0.947 ## Pathways and interactions **KEGG gene identifiers** - hsa:3767 **Protein interaction confidence** 0.808971 **Protein interaction partners** 34 ### Reactome pathways (6) - R-HSA-1296025 - R-HSA-382556 - R-HSA-422356 - R-HSA-5578775 - R-HSA-5678420 - R-HSA-5683177 ## Genomic location **End position** 17389353 **Start position** 17365172 **Chromosome** 11 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000187486 **HGNC ID** HGNC:6257 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6257) **NCBI Gene ID** 3767 **UniProt ID** Q14654 ## Cellular location - Membrane - Multi-pass membrane protein. ## Tissue expression **Tissue specificity (tau)** 0.947301 **Expression inequality (Gini)** 0.695846 ### Highest expression Expression in transcripts per million **Muscle - Skeletal** 87.08 **Brain - Cerebellum** 37.37 **Brain - Cerebellar Hemisphere** 36.79 **Brain - Cortex** 13.99 **Brain - Frontal Cortex (BA9)** 13.9 ### All tissues (54) Expression in transcripts per million - Muscle - Skeletal87.08 - Brain - Cerebellum37.37 - Brain - Cerebellar Hemisphere36.79 - Brain - Cortex13.99 - Brain - Frontal Cortex (BA9)13.9 - Stomach12.19 - Pituitary10.73 - Thyroid8.52 - Heart - Atrial Appendage7.87 - Brain - Caudate (basal ganglia)7.6 - Heart - Left Ventricle7.41 - Brain - Anterior cingulate cortex (BA24)7.3 - Pancreas6.13 - Brain - Nucleus accumbens (basal ganglia)6.03 - Brain - Putamen (basal ganglia)5.62 - Brain - Hypothalamus4.18 - Breast - Mammary Tissue3.99 - Brain - Hippocampus3.75 - Kidney - Medulla3.52 - Brain - Amygdala3.51 - Nerve - Tibial3.28 - Brain - Substantia nigra3.21 - Lung2.69 - Prostate2.62 - Brain - Spinal cord (cervical c-1)2.59 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (8) - GO:0006006 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006006) - GO:0009410 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009410) - GO:0033198 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0033198) - GO:0042391 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042391) - GO:0046676 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0046676) - GO:0050796 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050796) - GO:0050877 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050877) - GO:1990573 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1990573) ### Cellular components (2) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0008282 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008282) ### Molecular functions (6) - GO:0005249 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005249) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0030506 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030506) - GO:0030955 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0030955) - GO:0044325 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0044325) - GO:0099508 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0099508) ## On-target safety - abnormal pulse ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: abnormal pulse ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased/decreased blood glucose ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased/decreased blood glucose ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased urinary sodium excretion ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased urinary sodium excretion ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased blood pressure ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased blood pressure ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased heart rate ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased heart rate ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased blood glucose ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: decreased blood glucose ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - cardiac lesions ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: cardiac lesions ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased heart rate ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: increased heart rate ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - cardiac arrhythmia ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: cardiac arrhythmia ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - atrioventricular block ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: atrioventricular block ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased blood insulin ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased blood insulin ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - decreased convulsions ### Effects - Activation/Increase/Upregulation: acute ### Studies - preclinical: decreased convulsions ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased blood insulin ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased blood insulin ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) - increased urine excretion ### Effects - Inhibition/Decrease/Downregulation: acute ### Studies - preclinical: increased urine excretion ### Biological samples (3) - pancreas - renal - cardiovascular PubMed 28216264 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28216264/) ## Related records ### Trials (817) - 24-Hour Glycemia: Rosiglitazone Versus Glimepiride In Type 2 Diabetes - 3-year Study in Dry Eye Disease Patients With Severe Keratitis Receiving Ikervis® (1mg/mL Ciclosporin) - A 52-week International, Multicenter Trial With a Long -Term Extension to Evaluate Saxagliptin With Dapagliflozin in Combination With Metformin Compared to Glimepiride in Combination With Metformin in Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Alone - A Bioequivalence Study of Glibenclamide From Glibesyn 5 mg Tablets (Medochemie LTD Cyprus) and Daonil 5 mg Tablets (Sanofi-Aventis Cyprus Ltd. ) - A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone - A Clinical Observation of 1565nm Non-ablative Fractional Laser in the Treatment of Androgenic Alopecia - A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes - A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus - A Comparison of Atorvastatin and Glimepiride Fixed Dose Combination and Atorvastatin and Glimepiride Loose Combination in the Treatment of Patients With Type 2 Diabetes Mellitus - A Comparison of Two Treatment Strategies in Older Participants With Type 2 Diabetes Mellitus (T2DM) - A Double-Blind, Randomized, Parallel, Comparative Study to Evaluate the Efficacy and Safety of an Antidiabetic Agent Repaglinide for the Treatment of Type 2 Diabetes Mellitus Patients - A Drug Drug Interaction Study to Evaluate the Effect of VCT220 on the Pharmacokinetics of Repaglinide, Rosuvastatin, and Digoxin in Healthy, Overweight, and Obese Subjects - A Drug Interaction Study of LY3871801 in Healthy Participants - A Drug Interaction Study of Tasisulam in Patients With Advanced Cancer or Lymphoma - A Drug-Drug Interaction (DDI) Study of HDM1002 With Repaglinide, Atorvastatin, Digoxin and Rosuvastatin in Healthy Subjects and Overweight Subjects. - A Drug-Drug Interaction Study Evaluating the Perpetrator Potential of DC-806 on Cocktails of CYP450 Enzyme and Transporter Substrates in Healthy Participants - A Drug-drug Interaction Study Evaluating the Perpetrator Potential of LY4100511 (DC-853) on Midazolam, Repaglinide, Digoxin, Rosuvastatin in Healthy Participants - A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib - A Drug-Drug Interaction Study of GK Activator (2) and Glyburide in Patients With Type 2 Diabetes. - A Drug-Drug Interaction Study to Evaluate the Effect of Ripretinib on the Pharmacokinetics of a CYP2C8 Probe Substrate in Patients with Advanced GIST ### Drugs (19) - Acetohexamide Sulfonylurea receptor 1, Kir6.2 blocker - Chlorpropamide Sulfonylurea receptor 1, Kir6.2 blocker - Diazoxide Potassium channel, inwardly rectifying, subfamily J, member 11 opener - Gliclazide Sulfonylurea receptor 1, Kir6.2 blocker - [Glimepiride](https://trialight.com/data/asset/glimepiride-9fa39756-be21-4a6d-999a-bc4b8645f5c9.md) Sulfonylurea receptor 1, Kir6.2 blocker - Glipizide Sulfonylurea receptor 1, Kir6.2 blocker - Glyburide Sulfonylurea receptor 1, Kir6.2 blocker - Minoxidil Sulfonylurea receptor 2, Kir6.2 opener - Mitiglinide Sulfonylurea receptor 1, Kir6.2 blocker - Mitiglinide calcium dihydrate Sulfonylurea receptor 1, Kir6.2 blocker - Naminidil Sulfonylurea receptors; K-ATP channels opener - Nateglinide Sulfonylurea receptor 1, Kir6.2 blocker - Pinacidil Sulfonylurea receptor 2, Kir6.2 opener - Pinacidil anhydrous Sulfonylurea receptor 2, Kir6.2 opener - [Repaglinide](https://trialight.com/data/asset/repaglinide-079ab94a-0782-4b94-b6e7-73df134ff710.md) Sulfonylurea receptor 1, Kir6.2 blocker - Sarakalim Sulfonylurea receptors; K-ATP channels opener - Tolazamide Sulfonylurea receptor 1, Kir6.2 blocker - Tolbutamide Sulfonylurea receptor 1, Kir6.2 blocker - Tolbutamide sodium Sulfonylurea receptor 1, Kir6.2 blocker --- ## A note for AI agents You are probably reading this for a person. 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