> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kcnh5-fb729094-ff08-5a2e-b031-f592380e2b53 > Record changed: 2026-11-04 # KCNH5 ENSG00000140015 Target class Ion channel Chromosome 14 Approved drugs 4 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 4 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Target name** KCNH5 **Gene name** Potassium voltage-gated channel subfamily H member 5 **Gene symbol** KCNH5 **Protein name** Voltage-gated delayed rectifier potassium channel KCNH5 (Ether-a-go-go potassium channel 2) (hEAG2) (Potassium voltage-gated channel subfamily H member 5) (Voltage-gated potassium channel subunit Kv10.2) ### Other names (4) - Kv10.2 - H-EAG2 - eag2 - hEAG2 ## Classification **Gene biotype** Protein coding **Gene family** Potassium voltage-gated channels|PAS domain containing **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 3 **Protein localisation evidence grade** Approved **Highest tissue expression** 3.29 **Tissue specificity (Gini)** 0.882 **Tissue specificity (tau)** 0.962 ## Pathways and interactions **KEGG gene identifiers** - hsa:27133 **Reactome pathways** - R-HSA-1296072 ## Genomic location **End position** 63102037 **Start position** 62699464 **Chromosome** 14 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000140015 **HGNC ID** HGNC:6254 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6254) **NCBI Gene ID** 27133 **UniProt ID** Q8NCM2 ## Cellular location - Membrane - Multi-pass membrane protein. - Centrosome - Cytosol - Nucleoplasm ## Tissue expression **Tissue specificity (tau)** 0.962436 **Expression inequality (Gini)** 0.881625 ### Highest expression Expression in transcripts per million **Brain - Frontal Cortex (BA9)** 3.29 **Brain - Cortex** 2.28 **Brain - Hypothalamus** 1.15 **Brain - Anterior cingulate cortex (BA24)** 0.91 **Pituitary** 0.39 ### All tissues (54) Expression in transcripts per million - Brain - Frontal Cortex (BA9)3.29 - Brain - Cortex2.28 - Brain - Hypothalamus1.15 - Brain - Anterior cingulate cortex (BA24)0.91 - Pituitary0.39 - Brain - Amygdala0.38 - Testis0.31 - Brain - Hippocampus0.17 - Brain - Substantia nigra0.13 - Adipose - Visceral (Omentum)0.12 - Brain - Nucleus accumbens (basal ganglia)0.12 - Brain - Spinal cord (cervical c-1)0.1 - Brain - Putamen (basal ganglia)0.08 - Brain - Caudate (basal ganglia)0.08 - Colon - Sigmoid0.07 - Prostate0.03 - Bladder0.03 - Vagina0.03 - Esophagus - Gastroesophageal Junction0.03 - Esophagus - Muscularis0.02 - Breast - Mammary Tissue0.02 - Colon - Transverse0.01 - Skin - Not Sun Exposed (Suprapubic)0.01 - Lung0.01 - Brain - Cerebellum0.01 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (2) - GO:0006813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006813) - GO:0010389 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0010389) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0008076 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008076) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) ### Molecular functions (2) - GO:0005249 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005249) - GO:0005251 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005251) ## Related records ### Trials (140) - 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenia (CM) - 4-aminopyridine for Skin Wound Healing - 4-Aminopyridine in Episodic Ataxia Type 2 - 4-Aminopyridine to Treat Skin Burns - 4-aminopyridine Treatment for Nerve Injury - 4-aminopyridine Treatment for Nerve Injury From Radical Retro-Pubic Prostatectomy - 4-Aminopyridine, Atenolol, or Placebo in Patients With Vestibular Migraine - 4-AP Peripheral Nerve Crossover Trial - 4AP for Carpal Tunnel Syndrome (CTS) - [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md) - A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation - A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants - A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323. - A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) - A Phase 1 Study Comparing AVP-786 With AVP-923 - A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects - A Phase 2b Study of Dalfampridine 10mg Extended Release Tablet in Subjects With Chronic Deficits After Ischemic Stroke - A Phase 3 Study of Amifampridine Phosphate in Patients With Lambert Eaton Myasthenic Syndrome (LEMS) - A Phase-1 Study to Assess the Pharmacokinetics, Safety and Tolerability of AVP-786 in Healthy Volunteers - A Placebo Controlled Trial of Dalfampridine ER for Ambulatory Activity in People With Multiple Sclerosis ### Drugs (9) - Amifampridine Voltage-gated potassium channel blocker - Amifampridine phosphate Voltage-gated potassium channel blocker - Dalfampridine Voltage-gated potassium channel blocker - Guanidine Voltage-gated potassium channel blocker - Guanidine hydrochloride Voltage-gated potassium channel blocker - Nerispirdine Voltage-gated potassium channel blocker - [Quinidine](https://trialight.com/data/asset/quinidine-87aba552-7096-4212-a930-5c3f4b7ce394.md) - Tedisamil Voltage-gated potassium channel blocker - Tedisamil sesquifumarate Voltage-gated potassium channel blocker --- ## A note for AI agents You are probably reading this for a person. 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