> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kcnh1-916406a2-e9f5-5d17-b392-16dfb4b7721d > Record changed: 2026-11-04 # KCNH1 ENSG00000143473 Target class Ion channel Chromosome 1 Approved drugs 4 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 4 **ClinGen gene-disease validity** Definitive **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Target name** KCNH1 **Gene name** Potassium voltage-gated channel subfamily H member 1 **Gene symbol** KCNH1 **Protein name** Voltage-gated delayed rectifier potassium channel KCNH1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Potassium voltage-gated channel subfamily H member 1) (Voltage-gated potassium channel subunit Kv10.1) ### Other names (6) - Kv10.1 - eag - h-eag - eag1 - hEAG - K(V)10.1 ## Classification **Gene biotype** Protein coding **Gene family** Potassium voltage-gated channels|PAS domain containing **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 5 **Protein localisation evidence grade** Approved **Highest tissue expression** 6.42 **Tissue specificity (Gini)** 0.718 **Tissue specificity (tau)** 0.93 ## Pathways and interactions **KEGG gene identifiers** - hsa:3756 **Reactome pathways** - R-HSA-1296072 **Protein interaction confidence** 0.773 **Protein interaction partners** 10 ## Genomic location **End position** 211134183 **Start position** 210676823 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000143473 **HGNC ID** HGNC:6250 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6250) **NCBI Gene ID** 3756 **UniProt ID** O95259 ## Cellular location - Cell membrane - Multi-pass membrane protein . Nucleus inner membrane - Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Presynaptic cell membrane . Perikaryon . Postsynaptic density membrane . Early endosome membrane . Note=Perinuclear KCNH1 is located to NPC-free islands. - Vesicles ### Publication evidence (10) - PubMed 10880439 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/10880439/) - PubMed 11943152 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11943152/) - PubMed 21559285 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/21559285/) - PubMed 22732247 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22732247/) - PubMed 22841712 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/22841712/) - PubMed 25556795 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25556795/) - PubMed 27005320 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27005320/) - PubMed 27325704 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27325704/) - PubMed 27618660 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27618660/) - PubMed 9738473 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/9738473/) ## Tissue expression **Tissue specificity (tau)** 0.929701 **Expression inequality (Gini)** 0.717657 ### Highest expression Expression in transcripts per million **Brain - Cerebellar Hemisphere** 6.42 **Brain - Cerebellum** 6 **Brain - Frontal Cortex (BA9)** 3.03 **Brain - Cortex** 2.41 **Testis** 1.13 ### All tissues (54) Expression in transcripts per million - Brain - Cerebellar Hemisphere6.42 - Brain - Cerebellum6 - Brain - Frontal Cortex (BA9)3.03 - Brain - Cortex2.41 - Testis1.13 - Brain - Anterior cingulate cortex (BA24)0.89 - Cervix - Ectocervix0.86 - Brain - Nucleus accumbens (basal ganglia)0.77 - Brain - Spinal cord (cervical c-1)0.67 - Cervix - Endocervix0.58 - Brain - Caudate (basal ganglia)0.58 - Nerve - Tibial0.47 - Small Intestine - Terminal Ileum0.4 - Brain - Hypothalamus0.39 - Brain - Hippocampus0.38 - Pituitary0.36 - Brain - Putamen (basal ganglia)0.36 - Brain - Amygdala0.34 - Fallopian Tube0.32 - Vagina0.28 - Colon - Sigmoid0.26 - Prostate0.24 - Bladder0.24 - Colon - Transverse0.23 - Uterus0.21 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (5) - GO:0006813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006813) - GO:0007520 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0007520) - GO:0042127 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042127) - GO:0071277 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071277) - GO:0071805 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071805) ### Cellular components (3) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0008076 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008076) - GO:0031901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0031901) ### Molecular functions (3) - GO:0005251 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005251) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:1902936 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:1902936) ## Related records ### Trials (336) - 131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma - 15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated - 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenia (CM) - 4-aminopyridine for Skin Wound Healing - 4-Aminopyridine in Episodic Ataxia Type 2 - 4-Aminopyridine to Treat Skin Burns - 4-aminopyridine Treatment for Nerve Injury - 4-aminopyridine Treatment for Nerve Injury From Radical Retro-Pubic Prostatectomy - 4-Aminopyridine, Atenolol, or Placebo in Patients With Vestibular Migraine - 4-AP Peripheral Nerve Crossover Trial - 4AP for Carpal Tunnel Syndrome (CTS) - 5HT3 Antagonism and Auditory Gating in Schizophrenia - A 4-week, Randomized, Rater-blinded, Parallel Study to Evaluate Quetiapine in Improving Sleep Quality of Schizophrenia - [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md) - A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation - A Comparison of Dexmedetomidine and Haloperidol in Patients With Intensive Care Unit (ICU)-Associated Agitation and Delirium - A Comparison of Risperidone With Haloperidol in Patients With Schizophrenia and Schizoaffective Disorder - A Comparison of Study Drug With Placebo and Haloperidol in Patients With Schizophrenia - A Comparison Study of the Efficacy of Quetiapine and Haloperidol in Agitated Adults in Emergency Room - A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma, GHoST Trial ### Drugs (16) - Amifampridine Voltage-gated potassium channel blocker - Amifampridine phosphate Voltage-gated potassium channel blocker - Astemizole - Clofilium - Clofilium phosphate - Dalfampridine Voltage-gated potassium channel blocker - Dofetilide - Guanidine Voltage-gated potassium channel blocker - Guanidine hydrochloride Voltage-gated potassium channel blocker - Haloperidol - Imipramine - Nerispirdine Voltage-gated potassium channel blocker - [Quinidine](https://trialight.com/data/asset/quinidine-87aba552-7096-4212-a930-5c3f4b7ce394.md) - Tedisamil Voltage-gated potassium channel blocker - Tedisamil sesquifumarate Voltage-gated potassium channel blocker - Terfenadine --- ## A note for AI agents You are probably reading this for a person. 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