> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kcna7-bc30fd31-d5d3-5a21-a101-b410d9c0e221 > Record changed: 2026-11-04 # KCNA7 ENSG00000104848 Target class Ion channel Chromosome 19 Approved drugs 4 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 4 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Target name** KCNA7 **Gene name** Potassium voltage-gated channel subfamily A member 7 **Gene symbol** KCNA7 **Protein name** Potassium voltage-gated channel subfamily A member 7 (Voltage-gated potassium channel subunit Kv1.7) ### Other names (2) - Kv1.7 - HAK6 ## Classification **Gene biotype** Protein coding **Gene family** Potassium voltage-gated channels|BTB domain containing **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 1 **Protein localisation evidence grade** Approved **Highest tissue expression** 19.88 **Tissue specificity (Gini)** 0.924 **Tissue specificity (tau)** 0.997 ## Pathways and interactions **KEGG gene identifiers** - hsa:3743 **Reactome pathways** - R-HSA-1296072 **Protein interaction confidence** 0.78025 **Protein interaction partners** 8 ## Genomic location **End position** 49072699 **Start position** 49067397 **Chromosome** 19 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000104848 **HGNC ID** HGNC:6226 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6226) **NCBI Gene ID** 3743 **UniProt ID** Q96RP8 ## Cellular location - Membrane - Multi-pass membrane protein . - Plasma membrane - Vesicles ## Tissue expression **Tissue specificity (tau)** 0.997001 **Expression inequality (Gini)** 0.924351 ### Highest expression Expression in transcripts per million **Muscle - Skeletal** 19.88 **Heart - Atrial Appendage** 0.72 **Testis** 0.25 **Heart - Left Ventricle** 0.23 **Skin - Sun Exposed (Lower leg)** 0.2 ### All tissues (54) Expression in transcripts per million - Muscle - Skeletal19.88 - Heart - Atrial Appendage0.72 - Testis0.25 - Heart - Left Ventricle0.23 - Skin - Sun Exposed (Lower leg)0.2 - Skin - Not Sun Exposed (Suprapubic)0.16 - Minor Salivary Gland0.11 - Prostate0.1 - Cells - Cultured fibroblasts0.09 - Vagina0.09 - Pituitary0.08 - Cervix - Ectocervix0.06 - Fallopian Tube0.06 - Esophagus - Mucosa0.06 - Uterus0.06 - Breast - Mammary Tissue0.05 - Ovary0.04 - Lung0.04 - Nerve - Tibial0.04 - Bladder0.04 - Thyroid0.04 - Adipose - Subcutaneous0.04 - Artery - Coronary0.04 - Artery - Aorta0.03 - Artery - Tibial0.03 And 29 more, listed on the interactive page. ## Biological functions ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (348) - 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenia (CM) - 4-aminopyridine for Skin Wound Healing - 4-Aminopyridine in Episodic Ataxia Type 2 - 4-Aminopyridine to Treat Skin Burns - 4-aminopyridine Treatment for Nerve Injury - 4-aminopyridine Treatment for Nerve Injury From Radical Retro-Pubic Prostatectomy - 4-Aminopyridine, Atenolol, or Placebo in Patients With Vestibular Migraine - 4-AP Peripheral Nerve Crossover Trial - 4AP for Carpal Tunnel Syndrome (CTS) - A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone - [A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)](https://trialight.com/data/trial/a-clinical-trial-to-evaluate-mk-4208-embibatinib-in-healthy-7e3461de-b189-4af2-af82-5175294701bc.md) - A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation - A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants - A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323. - A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) - A Phase 1 Study Comparing AVP-786 With AVP-923 - A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects - A Phase 2b Study of Dalfampridine 10mg Extended Release Tablet in Subjects With Chronic Deficits After Ischemic Stroke - A Phase 3 Study of Amifampridine Phosphate in Patients With Lambert Eaton Myasthenic Syndrome (LEMS) - A Phase I Study to Assess PK of AZD7986 Alone & With Verapamil, Itraconazole or Diltiazem in Healthy Subjects ### Drugs (14) - Amifampridine Voltage-gated potassium channel blocker - Amifampridine phosphate Voltage-gated potassium channel blocker - Amiodarone - Dalfampridine Voltage-gated potassium channel blocker - Flecainide - Guanidine Voltage-gated potassium channel blocker - Guanidine hydrochloride Voltage-gated potassium channel blocker - Nerispirdine Voltage-gated potassium channel blocker - [Quinidine](https://trialight.com/data/asset/quinidine-87aba552-7096-4212-a930-5c3f4b7ce394.md) - Tedisamil Voltage-gated potassium channel blocker - Tedisamil sesquifumarate Voltage-gated potassium channel blocker - Tetrylammonium - Tetrylammonium bromide - Verapamil --- ## A note for AI agents You are probably reading this for a person. 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