KCNA7
ENSG00000104848
Target class
Ion channel
Chromosome
19
Approved drugs
4
Clinical candidates (approved and in development)
6
- Approved drugs
- 4
- Clinical candidates (approved and in development)
- 6
- Chemical probe available
- No
- Target name
- KCNA7
- Gene name
- Potassium voltage-gated channel subfamily A member 7
- Gene symbol
- KCNA7
- Protein name
- Potassium voltage-gated channel subfamily A member 7 (Voltage-gated potassium channel subunit Kv1.7)
- Kv1.7
- HAK6
- Gene biotype
- Protein coding
- Gene family
- Potassium voltage-gated channels|BTB domain containing
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 1
- Protein localisation evidence grade
- Approved
- Highest tissue expression
- 19.88
- Tissue specificity (Gini)
- 0.924
- Tissue specificity (tau)
- 0.997
- KEGG gene identifiers
- hsa:3743
- Reactome pathways
- R-HSA-1296072
- Protein interaction confidence
- 0.78025
- Protein interaction partners
- 8
- End position
- 49072699
- Start position
- 49067397
- Chromosome
- 19
- Strand
- Reverse
- Membrane
- Multi-pass membrane protein .
- Plasma membrane
- Vesicles
- Tissue specificity (tau)
- 0.997001
- Expression inequality (Gini)
- 0.924351
Expression in transcripts per million
- Muscle - Skeletal
- 19.88
- Heart - Atrial Appendage
- 0.72
- Testis
- 0.25
- Heart - Left Ventricle
- 0.23
- Skin - Sun Exposed (Lower leg)
- 0.2
Expression in transcripts per million
- Muscle - Skeletal19.88
- Heart - Atrial Appendage0.72
- Testis0.25
- Heart - Left Ventricle0.23
- Skin - Sun Exposed (Lower leg)0.2
- Skin - Not Sun Exposed (Suprapubic)0.16
- Minor Salivary Gland0.11
- Prostate0.1
- Cells - Cultured fibroblasts0.09
- Vagina0.09
- Pituitary0.08
- Cervix - Ectocervix0.06
- Fallopian Tube0.06
- Esophagus - Mucosa0.06
- Uterus0.06
- Breast - Mammary Tissue0.05
- Ovary0.04
- Lung0.04
- Nerve - Tibial0.04
- Bladder0.04
- Thyroid0.04
- Adipose - Subcutaneous0.04
- Artery - Coronary0.04
- Artery - Aorta0.03
- Artery - Tibial0.03
And 29 more, listed on the interactive page.
Cellular components
- GO:0005886
Molecular functions
- GO:0005515
Related records
Trials (348)
- 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenia (CM)
- 4-aminopyridine for Skin Wound Healing
- 4-Aminopyridine in Episodic Ataxia Type 2
- 4-Aminopyridine to Treat Skin Burns
- 4-aminopyridine Treatment for Nerve Injury
- 4-aminopyridine Treatment for Nerve Injury From Radical Retro-Pubic Prostatectomy
- 4-Aminopyridine, Atenolol, or Placebo in Patients With Vestibular Migraine
- 4-AP Peripheral Nerve Crossover Trial
- 4AP for Carpal Tunnel Syndrome (CTS)
- A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone
- A Clinical Trial to Evaluate MK-4208/Embibatinib in Healthy Adult Participants (MK-4208-001/Embibatinib-1014)
- A Comparison of Antiarrhythmic Drug Therapy and Radio Frequency Catheter Ablation in Patients With Paroxysmal Atrial Fibrillation
- A Drug-Drug Interaction Study of Orforglipron (LY3502970) With Quinidine in Healthy Participants
- A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323.
- A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
- A Phase 1 Study Comparing AVP-786 With AVP-923
- A Phase 1, Drug Interaction Study Between AVP-786 and Paroxetine and Between AVP-786 and Duloxetine in Healthy Subjects
- A Phase 2b Study of Dalfampridine 10mg Extended Release Tablet in Subjects With Chronic Deficits After Ischemic Stroke
- A Phase 3 Study of Amifampridine Phosphate in Patients With Lambert Eaton Myasthenic Syndrome (LEMS)
- A Phase I Study to Assess PK of AZD7986 Alone & With Verapamil, Itraconazole or Diltiazem in Healthy Subjects
Drugs (14)
- Amifampridine Voltage-gated potassium channel blocker
- Amifampridine phosphate Voltage-gated potassium channel blocker
- Amiodarone
- Dalfampridine Voltage-gated potassium channel blocker
- Flecainide
- Guanidine Voltage-gated potassium channel blocker
- Guanidine hydrochloride Voltage-gated potassium channel blocker
- Nerispirdine Voltage-gated potassium channel blocker
- Quinidine
- Tedisamil Voltage-gated potassium channel blocker
- Tedisamil sesquifumarate Voltage-gated potassium channel blocker
- Tetrylammonium
- Tetrylammonium bromide
- Verapamil