> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kcna5-23b49e8a-ca45-574d-97c6-0096cc25ba63 > Record changed: 2026-11-04 # KCNA5 ENSG00000130037 Target class Ion channel Chromosome 12 Approved drugs 5 Clinical candidates (approved and in development) 7 ## Clinical evidence **Approved drugs** 5 **Clinical candidates (approved and in development)** 7 ## Druggability **Chemical probe available** No ## Names **Target name** KCNA5 **Gene name** Potassium voltage-gated channel subfamily A member 5 **Gene symbol** KCNA5 **Protein name** Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5) ### Other names (3) - Kv1.5 - HK2 - HPCN1 ## Classification **Gene biotype** Protein coding **Gene family** Potassium voltage-gated channels|BTB domain containing **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 38 **Highest tissue expression** 82.62 **Tissue specificity (Gini)** 0.771 **Tissue specificity (tau)** 0.93 ## Pathways and interactions **KEGG gene identifiers** - hsa:3741 **Protein interaction confidence** 0.826043 **Protein interaction partners** 23 ### Reactome pathways (2) - R-HSA-1296072 - R-HSA-5576890 ## Genomic location **End position** 5046788 **Start position** 5043879 **Chromosome** 12 **Strand** Forward ## Identifiers **Ensembl gene ID** ENSG00000130037 **HGNC ID** HGNC:6224 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6224) **NCBI Gene ID** 3741 **UniProt ID** P22460 ## Cellular location - Cell membrane - Multi-pass membrane protein . ### Publication evidence (3) - PubMed 12130714 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/12130714/) - PubMed 20018952 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20018952/) - PubMed 8505626 Source: [pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/8505626/) ## Tissue expression **Tissue specificity (tau)** 0.929619 **Expression inequality (Gini)** 0.770634 ### Highest expression Expression in transcripts per million **Artery - Aorta** 82.62 **Artery - Tibial** 81.79 **Artery - Coronary** 74.61 **Heart - Atrial Appendage** 35.57 **Pituitary** 13.39 ### All tissues (54) Expression in transcripts per million - Artery - Aorta82.62 - Artery - Tibial81.79 - Artery - Coronary74.61 - Heart - Atrial Appendage35.57 - Pituitary13.39 - Brain - Nucleus accumbens (basal ganglia)8.54 - Brain - Hypothalamus7.2 - Esophagus - Gastroesophageal Junction6.52 - Colon - Sigmoid5.01 - Fallopian Tube3.84 - Lung3.83 - Brain - Frontal Cortex (BA9)3.68 - Bladder3.65 - Brain - Caudate (basal ganglia)3.5 - Nerve - Tibial3.22 - Esophagus - Muscularis2.96 - Brain - Hippocampus2.92 - Uterus2.86 - Ovary2.84 - Brain - Putamen (basal ganglia)2.8 - Brain - Anterior cingulate cortex (BA24)2.75 - Brain - Cortex2.74 - Colon - Transverse2.59 - Adipose - Subcutaneous2.49 - Brain - Spinal cord (cervical c-1)2.16 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes (12) - GO:0006813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006813) - GO:0042391 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0042391) - GO:0050796 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0050796) - GO:0060081 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060081) - GO:0060372 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0060372) - GO:0071805 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0071805) - GO:0086014 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086014) - GO:0086050 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086050) - GO:0086052 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086052) - GO:0086091 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086091) - GO:0097623 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097623) - GO:0098914 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0098914) ### Cellular components (8) - GO:0005794 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005794) - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) - GO:0005901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005901) - GO:0008076 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0008076) - GO:0009986 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0009986) - GO:0014704 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0014704) - GO:0034705 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0034705) - GO:0045121 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0045121) ### Molecular functions (10) - GO:0005249 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005249) - GO:0005251 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005251) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) - GO:0015271 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0015271) - GO:0019901 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0019901) - GO:0051393 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0051393) - GO:0086087 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086087) - GO:0086089 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086089) - GO:0086090 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0086090) - GO:0097110 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0097110) ## Related records ### Trials (2,056) - "Efficacy of Local Anesthetic for Postoperative Pain in Gynecologic Laparoscopy" - "The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors" - (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes - 0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka - 1% Chloroprocaine(PF) vs. Bupivacaine Spinals - 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula - 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty - 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenia (CM) - 4-aminopyridine for Skin Wound Healing - 4-Aminopyridine in Episodic Ataxia Type 2 - 4-Aminopyridine to Treat Skin Burns - 4-aminopyridine Treatment for Nerve Injury - 4-aminopyridine Treatment for Nerve Injury From Radical Retro-Pubic Prostatectomy - 4-Aminopyridine, Atenolol, or Placebo in Patients With Vestibular Migraine - 4-AP Peripheral Nerve Crossover Trial - 4-drug Nerve Block Versus Plain Local Anesthetic for Knee and Hip Arthroplasty Analgesia in Veterans - 4AP for Carpal Tunnel Syndrome (CTS) - A 3 Months Duration Interventional Study Comparing Hemodynamic Parameters Between Bolus and Fractionated Group. - A Clinical Study of MK-4318 and Diltiazem in Healthy People (MK-4318-003) - A Clinical Study to Compare BupiZenge With Lidocaine for Pain Due to Oral Mucositis in Patients With Head and Neck Cancer. ### Drugs (21) - Ajmaline - Amifampridine Voltage-gated potassium channel blocker - Amifampridine phosphate Voltage-gated potassium channel blocker - Bupivacaine - Clofilium - Clofilium phosphate - Dalfampridine Voltage-gated potassium channel blocker - Diltiazem - Dronedarone - Flecainide - Guanidine Voltage-gated potassium channel blocker - Guanidine hydrochloride Voltage-gated potassium channel blocker - Nerispirdine Voltage-gated potassium channel blocker - Nifedipine - Propafenone - [Quinidine](https://trialight.com/data/asset/quinidine-87aba552-7096-4212-a930-5c3f4b7ce394.md) - Resiniferatoxin - Tedisamil Voltage-gated potassium channel blocker - Tedisamil sesquifumarate Voltage-gated potassium channel blocker - Vernakalant Voltage-gated potassium channel subunit Kv1.5 blocker --- ## A note for AI agents You are probably reading this for a person. 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