KCNA5
ENSG00000130037
Target class
Ion channel
Chromosome
12
Approved drugs
5
Clinical candidates (approved and in development)
7
- Approved drugs
- 5
- Clinical candidates (approved and in development)
- 7
- Chemical probe available
- No
- Target name
- KCNA5
- Gene name
- Potassium voltage-gated channel subfamily A member 5
- Gene symbol
- KCNA5
- Protein name
- Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5)
- Kv1.5
- HK2
- HPCN1
- Gene biotype
- Protein coding
- Gene family
- Potassium voltage-gated channels|BTB domain containing
- Target class
- Ion channel
- Target type
- Human gene
- Tissues expressed in
- 38
- Highest tissue expression
- 82.62
- Tissue specificity (Gini)
- 0.771
- Tissue specificity (tau)
- 0.93
- KEGG gene identifiers
- hsa:3741
- Protein interaction confidence
- 0.826043
- Protein interaction partners
- 23
- R-HSA-1296072
- R-HSA-5576890
- End position
- 5046788
- Start position
- 5043879
- Chromosome
- 12
- Strand
- Forward
- Cell membrane
- Multi-pass membrane protein .
- PubMed 12130714
- PubMed 20018952
- PubMed 8505626
- Tissue specificity (tau)
- 0.929619
- Expression inequality (Gini)
- 0.770634
Expression in transcripts per million
- Artery - Aorta
- 82.62
- Artery - Tibial
- 81.79
- Artery - Coronary
- 74.61
- Heart - Atrial Appendage
- 35.57
- Pituitary
- 13.39
Expression in transcripts per million
- Artery - Aorta82.62
- Artery - Tibial81.79
- Artery - Coronary74.61
- Heart - Atrial Appendage35.57
- Pituitary13.39
- Brain - Nucleus accumbens (basal ganglia)8.54
- Brain - Hypothalamus7.2
- Esophagus - Gastroesophageal Junction6.52
- Colon - Sigmoid5.01
- Fallopian Tube3.84
- Lung3.83
- Brain - Frontal Cortex (BA9)3.68
- Bladder3.65
- Brain - Caudate (basal ganglia)3.5
- Nerve - Tibial3.22
- Esophagus - Muscularis2.96
- Brain - Hippocampus2.92
- Uterus2.86
- Ovary2.84
- Brain - Putamen (basal ganglia)2.8
- Brain - Anterior cingulate cortex (BA24)2.75
- Brain - Cortex2.74
- Colon - Transverse2.59
- Adipose - Subcutaneous2.49
- Brain - Spinal cord (cervical c-1)2.16
And 29 more, listed on the interactive page.
- GO:0006813
- GO:0042391
- GO:0050796
- GO:0060081
- GO:0060372
- GO:0071805
- GO:0086014
- GO:0086050
- GO:0086052
- GO:0086091
- GO:0097623
- GO:0098914
- GO:0005794
- GO:0005886
- GO:0005901
- GO:0008076
- GO:0009986
- GO:0014704
- GO:0034705
- GO:0045121
- GO:0005249
- GO:0005251
- GO:0005515
- GO:0015271
- GO:0019901
- GO:0051393
- GO:0086087
- GO:0086089
- GO:0086090
- GO:0097110
Related records
Trials (2,056)
- "Efficacy of Local Anesthetic for Postoperative Pain in Gynecologic Laparoscopy"
- "The Efficacy of Exparel Versus a Multidrug Cocktail in Soft Tissue Tumors"
- (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes
- 0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka
- 1% Chloroprocaine(PF) vs. Bupivacaine Spinals
- 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula
- 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty
- 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenia (CM)
- 4-aminopyridine for Skin Wound Healing
- 4-Aminopyridine in Episodic Ataxia Type 2
- 4-Aminopyridine to Treat Skin Burns
- 4-aminopyridine Treatment for Nerve Injury
- 4-aminopyridine Treatment for Nerve Injury From Radical Retro-Pubic Prostatectomy
- 4-Aminopyridine, Atenolol, or Placebo in Patients With Vestibular Migraine
- 4-AP Peripheral Nerve Crossover Trial
- 4-drug Nerve Block Versus Plain Local Anesthetic for Knee and Hip Arthroplasty Analgesia in Veterans
- 4AP for Carpal Tunnel Syndrome (CTS)
- A 3 Months Duration Interventional Study Comparing Hemodynamic Parameters Between Bolus and Fractionated Group.
- A Clinical Study of MK-4318 and Diltiazem in Healthy People (MK-4318-003)
- A Clinical Study to Compare BupiZenge With Lidocaine for Pain Due to Oral Mucositis in Patients With Head and Neck Cancer.
Drugs (21)
- Ajmaline
- Amifampridine Voltage-gated potassium channel blocker
- Amifampridine phosphate Voltage-gated potassium channel blocker
- Bupivacaine
- Clofilium
- Clofilium phosphate
- Dalfampridine Voltage-gated potassium channel blocker
- Diltiazem
- Dronedarone
- Flecainide
- Guanidine Voltage-gated potassium channel blocker
- Guanidine hydrochloride Voltage-gated potassium channel blocker
- Nerispirdine Voltage-gated potassium channel blocker
- Nifedipine
- Propafenone
- Quinidine
- Resiniferatoxin
- Tedisamil Voltage-gated potassium channel blocker
- Tedisamil sesquifumarate Voltage-gated potassium channel blocker
- Vernakalant Voltage-gated potassium channel subunit Kv1.5 blocker