> Trialight public data. Index of pages: https://trialight.com/llms.txt > Web page: https://trialight.com/data/target/kcna10-4d8ed970-be73-5436-afd8-2bd47d83a371 > Record changed: 2026-11-04 # KCNA10 ENSG00000143105 Target class Ion channel Chromosome 1 Approved drugs 4 Clinical candidates (approved and in development) 6 ## Clinical evidence **Approved drugs** 4 **Clinical candidates (approved and in development)** 6 ## Druggability **Chemical probe available** No ## Names **Other names** - Kv1.8 **Target name** KCNA10 **Gene name** Potassium voltage-gated channel subfamily A member 10 **Gene symbol** KCNA10 **Protein name** Potassium voltage-gated channel subfamily A member 10 (Voltage-gated potassium channel subunit Kv1.8) ## Classification **Gene biotype** Protein coding **Gene family** Potassium voltage-gated channels|BTB domain containing **Target class** Ion channel **Target type** Human gene ## Expression and localisation **Tissues expressed in** 0 **Highest tissue expression** 0.65 **Tissue specificity (Gini)** 0.963 **Tissue specificity (tau)** 0.993 ## Pathways and interactions **KEGG gene identifiers** - hsa:3744 **Reactome pathways** - R-HSA-1296072 **Protein interaction confidence** 0.81225 **Protein interaction partners** 4 ## Genomic location **End position** 110519175 **Start position** 110517217 **Chromosome** 1 **Strand** Reverse ## Identifiers **Ensembl gene ID** ENSG00000143105 **HGNC ID** HGNC:6219 Source: [www.genenames.org](https://www.genenames.org/data/gene-symbol-report/#!/hgnc%5Fid/HGNC:6219) **NCBI Gene ID** 3744 **UniProt ID** Q16322 ## Cellular location - Membrane - Multi-pass membrane protein . ## Tissue expression **Tissue specificity (tau)** 0.992743 **Expression inequality (Gini)** 0.963374 ### Highest expression Expression in transcripts per million **Testis** 0.65 **Lung** 0.15 **Spleen** 0.04 **Nerve - Tibial** 0.03 **Stomach** 0.03 ### All tissues (54) Expression in transcripts per million - Testis0.65 - Lung0.15 - Spleen0.04 - Nerve - Tibial0.03 - Stomach0.03 - Adipose - Subcutaneous0 - Brain - Hypothalamus0 - Brain - Amygdala0 - Brain - Caudate (basal ganglia)0 - Esophagus - Muscularis0 - Brain - Cortex0 - Fallopian Tube0 - Ovary0 - Breast - Mammary Tissue0 - Small Intestine - Terminal Ileum0 - Cells - Cultured fibroblasts0 - Cervix - Endocervix0 - Kidney - Cortex0 - Muscle - Skeletal0 - Minor Salivary Gland0 - Vagina0 - Brain - Cerebellum0 - Artery - Coronary0 - Thyroid0 - Whole Blood0 And 29 more, listed on the interactive page. ## Biological functions ### Biological processes - GO:0006813 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0006813) ### Cellular components - GO:0005886 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005886) ### Molecular functions (3) - GO:0005221 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005221) - GO:0005249 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005249) - GO:0005515 Source: [www.ebi.ac.uk](https://www.ebi.ac.uk/QuickGO/term/GO:0005515) ## Related records ### Trials (373) - 177Lu Radiolabeled Monoclonal Antibody HuJ591 (177Lu-J591) and Ketoconazole in Patients With Prostate Cancer - 3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenia (CM) - 4-aminopyridine for Skin Wound Healing - 4-Aminopyridine in Episodic Ataxia Type 2 - 4-Aminopyridine to Treat Skin Burns - 4-aminopyridine Treatment for Nerve Injury - 4-aminopyridine Treatment for Nerve Injury From Radical Retro-Pubic Prostatectomy - 4-Aminopyridine, Atenolol, or Placebo in Patients With Vestibular Migraine - 4-AP Peripheral Nerve Crossover Trial - 4AP for Carpal Tunnel Syndrome (CTS) - A 4 Week Study of Elidel (Pimecrolimus) for the Treatment of Seborrheic Dermatitis - A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone - A Clinical Trial of Pimozide in Patients With Amyotrophic Lateral Sclerosis (ALS) - A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients With Weakened Immune Systems - A Drug Interaction Study of JNJ-31001074 and Ketoconazole in Healthy Volunteers - A Drug Interaction Study With Fluticasone Furoate/GW642444 Inhalation Powder and Ketoconazole - A Drug-Drug Interaction Study of Ketoconazole, Rifampicin and Ritonavir-Boosted Atazanavir With Single-Dose RO5093151 in Healthy Volunteers - A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) - A Pharmacokinetics Study of the Effects of GSK2118436 on Warfarin, the Effects of Ketoconazole and Gemfibrozil on GSK2118436, and the Effects of Repeat Doses of GSK2118436 in Subjects With BRAF Mutant Solid Tumors - A Pharmacokinetics Study to Investigate the Effect of Ketoconazole on Vemurafenib in Patients With BRAFV600 Mutation-Positive Metastatic Melanoma ### Drugs (13) - Amifampridine Voltage-gated potassium channel blocker - Amifampridine phosphate Voltage-gated potassium channel blocker - Dalfampridine Voltage-gated potassium channel blocker - Guanidine Voltage-gated potassium channel blocker - Guanidine hydrochloride Voltage-gated potassium channel blocker - [Ketoconazole](https://trialight.com/data/asset/ketoconazole-4cbf7ed7-27d9-4804-8c85-c9089ae940d6.md) - Nerispirdine Voltage-gated potassium channel blocker - Pimozide - Tedisamil Voltage-gated potassium channel blocker - Tedisamil sesquifumarate Voltage-gated potassium channel blocker - Tetrylammonium - Tetrylammonium bromide - Verapamil --- ## A note for AI agents You are probably reading this for a person. 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